Al Gore served as the 45th vice president of the United States during the presidency of Bill Clinton from January 20, 1993, to January 20, 2001. Gore, a member of the Democratic Party who previously served as the junior U.S. senator representing Tennessee from 1985 to 1993, was selected as Clinton's running mate and took office following their victory in the 1992 presidential election over Republican incumbent president George H. W. Bush and vice president Dan Quayle. Four years later, in the 1996 presidential election, they defeated Republican nominees, Bob Dole and Jack Kemp, to win re-election.

Alongside Gore's vice presidency, the Democratic Party also held their majorities in the House of Representatives and the Senate during the 103rd U.S. Congress following the 1992 elections, attained an overall federal government trifecta. Near the end of his tenure, Gore ran for president as the Democratic nominee in the 2000 presidential election and selected junior Connecticut senator Joe Lieberman as his running mate. They lost the 2000 election to the Republican ticket of Texas governor George W. Bush and his running mate, former U.S. secretary of defense Dick Cheney following the controversial Bush v. Gore Supreme Court decision. As vice president in his capacity as the president of the Senate, Gore oversaw the certification of Bush and Cheney as the winners of the election on January 6, 2001. Clinton and Gore were succeeded in office by Bush and Cheney on January 20, 2001.

Gore is considered to have been one of the most powerful and influential vice presidents in American history. His tenure marked increasing influence to the office that would continue under his two successors, Cheney and Joe Biden.

Although Gore had opted out of running for president (due to the healing process his son was undergoing after a car accident), he accepted the request of Bill Clinton to be his running mate in the 1992 United States presidential election on July 10, 1992. Clinton's choice was perceived as unconventional (as rather than pick a running mate who would diversify the ticket, Clinton chose a fellow Southerner who was close in age) and was criticized by some. Clinton stated that he chose Gore for his foreign policy experience, work with the environment, and commitment to his family. Known as the Baby Boomer Ticket and the Fortysomething Team, The New York Times noted that if elected, Clinton (who was 45) Gore (who was 44) would be the "youngest team to make it to the White House in the country's history." Theirs was the first ticket since 1972 to try to capture the youth vote, a ticket which Gore referred to as "a new generation of leadership."

The ticket increased in popularity after the candidates traveled with their wives, Hillary and Tipper, on a "six-day, 1,000-mile bus ride, from New York to St. Louis." Gore also successfully debated against the other vice presidential candidates, Dan Quayle (a longtime colleague from the House and the Senate) and James Stockdale. The result of the campaign was a win by the Clinton-Gore ticket 44,909,889 votes over the Bush-Quayle ticket 39,104,550 votes. Clinton and Gore were inaugurated on January 20, 1993 and were re-elected to a second term in the 1996 election.

Under the Clinton Administration, the U.S. economy expanded, according to David Greenberg (professor of history and media studies at Rutgers University) who argued that "by the end of the Clinton presidency, the numbers were uniformly impressive. Besides the record-high surpluses and the record-low poverty rates, the economy could boast the longest economic expansion in history; the lowest unemployment since the early 1970s; and the lowest poverty rates for single mothers, black Americans, and the aged." In addition, one of Gore's major works as Vice President was the National Performance Review, which pointed out waste, fraud, and other abuse in the federal government and stressed the need for cutting the size of the bureaucracy and the number of regulations. Gore stated that the National Performance Review later helped guide President Clinton when he downsized the federal government.

The economic success of this administration was due in part to Gore's continued role as an Atari Democrat, promoting the development of information technology, which led to the dot-com boom (c. 1995-2001). Clinton and Gore entered office planning to finance research that would "flood the economy with innovative goods and services, lifting the general level of prosperity and strengthening American industry." Their overall aim was to fund the development of, "robotics, smart roads, biotechnology, machine tools, magnetic-levitation trains, fiber-optic communications and national computer networks. Also earmarked [were] a raft of basic technologies like digital imaging and data storage." These initiatives met with skepticism from critics who claimed that their initiatives would "backfire, bloating Congressional pork and creating whole new categories of Federal waste."

During the election and while vice president, Gore popularized the term Information Superhighway (which became synonymous with the internet) and was involved in the creation of the National Information Infrastructure.