A cradle of civilization is a location and a culture where civilization was developed independently of other civilizations in other locations. A civilization is any complex society characterized by the development of the state, social stratification, urbanization, and symbolic systems of communication beyond signed or spoken languages (namely, writing systems and graphic arts).

Scholars generally acknowledge six cradles of civilization: Mesopotamia, Ancient Egypt, Ancient India and Ancient China are believed to be the earliest in Afro-Eurasia, while the Caral–Supe civilization of coastal Peru and the Olmec civilization of Mexico are believed to be the earliest in the Americas. All of the cradles of civilization depended upon agriculture for sustenance (except possibly Caral–Supe which may have depended initially on marine resources). All depended upon farmers producing an agricultural surplus to support the centralized government, political leaders, religious leaders, and public works of the urban centers of the early civilizations.

The earliest signs of a process leading to sedentary culture can be seen in the Levant to as early as 12,000 BC, when the Natufian culture became sedentary; it evolved into an agricultural society by 10,000 BC. The importance of water to safeguard an abundant and stable food supply, due to favourable conditions for hunting, fishing and gathering resources including cereals, provided an initial wide spectrum economy that triggered the creation of permanent villages.

The earliest proto-urban settlements with several thousand inhabitants emerged in the Neolithic which began in Western Asia in 10,000 BC. The first cities to house several tens of thousands were Uruk, Ur, Kish and Eridu in Mesopotamia, followed by Susa in Elam and Memphis in Egypt, all by the 31st century BC (see Historical urban community sizes).

Historic times are marked apart from prehistoric times when "records of the past begin to be kept for the benefit of future generations"—in written or oral form. If the rise of civilization is taken to coincide with the development of writing out of proto-writing, then the Near Eastern Chalcolithic (the transitional period between the Neolithic and the Bronze Age during the 4th millennium BC) and the development of proto-writing in Harappa in the Indus Valley of South Asia around 3,300 BC are the earliest instances, followed by Chinese proto-writing evolving into the oracle bone script, and again by the emergence of Mesoamerican writing systems from about 900 BC.

In the absence of written documents, most aspects of the rise of early civilizations are contained in archaeological assessments that document the development of formal institutions and the material culture. A "civilized" way of life is ultimately linked to conditions coming almost exclusively from agriculture. Gordon Childe defined the development of civilization as the result of two successive revolutions: the Neolithic Revolution of Western Asia, triggering the development of settled communities, and the urban revolution which also first emerged in Western Asia, which enhanced tendencies towards dense settlements, specialized occupational groups, social classes, exploitation of surpluses, monumental public buildings and writing. Few of those conditions, however, are unchallenged by the records: dense cities were not attested in Egypt's Old Kingdom (unlike Mesopotamia) and cities had a dispersed population in the Maya area; the Incas lacked writing although they could keep records with Quipus which might also have had literary uses; and often monumental architecture preceded any indication of village settlement. For instance, in present-day Louisiana, researchers have determined that cultures that were primarily nomadic organized over generations to build earthwork mounds at seasonal settlements as early as 3400 BC. Rather than a succession of events and preconditions, the rise of civilization could equally be hypothesized as an accelerated process that started with incipient agriculture and culminated in the Oriental Bronze Age.

Scholars once thought that civilization began in the Fertile Crescent and spread out from there by influence. Scholars now believe that civilizations arose independently at several locations in both hemispheres. They have observed that sociocultural developments occurred along different timeframes. "Sedentary" and "nomadic" communities continued to interact considerably; they were not strictly divided among widely different cultural groups. The concept of a cradle of civilization has a focus where the inhabitants came to build cities, to create writing systems, to experiment in techniques for making pottery and using metals, to domesticate animals, and to develop complex social structures involving class systems.

Today, scholarship generally identifies six areas where civilization emerged independently: the Fertile Crescent, including Mesopotamia and the Levant; the Nile Valley; the Indo-Gangetic Plain; the North China Plain; the Andean Coast; and the Mesoamerican Gulf Coast.