Central Africa (French: Afrique centrale; Spanish: África central; Portuguese: África Central) is a subregion of the African continent comprising various countries according to different definitions. Middle Africa is an analogous term used by the United Nations in its geoscheme for Africa and consists of the following countries: Angola, Cameroon, Central African Republic, Chad, Democratic Republic of the Congo, Republic of the Congo, Equatorial Guinea, Gabon, and São Tomé and Príncipe. The United Nations Office for Central Africa also includes Burundi and Rwanda in the region, which are considered part of East Africa in the geoscheme. These eleven countries are members of the Economic Community of Central African States (ECCAS). Six of those countries (Cameroon, Central African Republic, Chad, Equatorial Guinea, Gabon, and Republic of the Congo) are also members of the Economic and Monetary Community of Central Africa (CEMAC) and share a common currency, the Central African CFA franc.

The African Development Bank, on the other hand, defines Central Africa as seven countries: Cameroon, Central African Republic, Chad, Republic of the Congo, Democratic Republic of Congo, Equatorial Guinea, and Gabon.

The Central African Federation (1953–1963), also called the Federation of Rhodesia and Nyasaland, was made up of what are now the nations of Malawi, Zambia, and Zimbabwe. Similarly, the Anglican Church of the Province of Central Africa covers dioceses in Botswana, Malawi, Zambia, and Zimbabwe, while the Church of Central Africa, Presbyterian has synods in Malawi, Zambia, and Zimbabwe. These states are now typically considered part of East or Southern Africa.

The Congo River basin has historically been ecologically significant to the populations of Central Africa, serving as an important supra-regional organization in Central Africa.

Archeological finds in Central Africa have been made which date back over 100,000 years. According to Zagato and Holl, there is evidence of iron smelting in the Central African Republic that may date back to 3000 to 2500 BCE. Extensive walled settlements have recently been found in Northeast Nigeria, approximately 60 km (37 mi) southwest of Lake Chad dating to the first millennium BCE.

Trade and improved agricultural techniques supported more sophisticated societies, leading to the early civilizations of West Africa: Sao, Kanem, Bornu, Shilluk, Baguirmi, and Wadai.

Around 2500 BCE, Bantu migrants had reached the Great Lakes Region in Central Africa. Halfway through the first millennium BCE, the Bantu had also settled as far south as what is now Angola.

The West African Sao civilization flourished from ca. the 6th century BCE to as late as the 16th century CE in northern Central Africa. The Sao lived by the Chari River south of Lake Chad in territory that later became part of Cameroon and Chad. They are the earliest people to have left clear traces of their presence in the territory of modern Cameroon. Today, several ethnic groups of northern Cameroon and southern Chad but particularly the Sara people claim descent from the civilization of the Sao. Sao artifacts show that they were skilled workers in bronze, copper, and iron. Finds include bronze sculptures and terra cotta statues of human and animal figures, coins, funerary urns, household utensils, jewelry, highly decorated pottery, and spears. The largest Sao archaeological finds have been made south of Lake Chad.