Palmistry is the pseudoscientific practice of fortune-telling through the study of the palm. Also known as palm reading, chiromancy, chirology or cheirology, the practice is found all over the world, with numerous cultural variations. Those who practice palmistry are generally called palmists, hand readers, hand analysts, or chirologists.

There are many—and often conflicting—interpretations of various lines and palmar features across various teachings of palmistry. Palmistry is widely viewed as a pseudoscience due to various contradictions between different interpretations and the lack of evidence for palmistry's predictions.

Palmistry is a practice common to many different places on the Eurasian landmass; it has been practiced in the cultures of Sumer, Babylonia, Arabia, Canaan, Persia, India, Nepal, Tibet and China.

The acupuncturist Yoshiaki Omura describes its roots in Hindu astrology (known in Sanskrit as jyotish), Chinese Yijing (I Ching), and Romani fortune tellers. Several thousand years ago, the Hindu sage Valmiki is thought to have written a book comprising 567 stanzas, the title of which translates in English as The Teachings of Valmiki Maharishi on Male Palmistry. Since ancient times, palmistry is considered to be a branch of Samudrika Shastra (Sanskrit: सामुद्रिक शास्त्र) which included the studies of marks all over a person's body such as astrology and palmistry (Hast-samudrika), as well as phrenology (kapal-samudrik) and face reading (physiognomy, mukh-samudrik). From India, the art of palmistry spread to China, Tibet and to other countries in Europe.

Palmistry also progressed independently in Greece where Anaxagoras practiced it. Aristotle (384–322 B.C.E.) reportedly discovered a treatise on the subject of palmistry on an altar of Hermes, which he then presented to Alexander the Great (356–323 B.C.E.), who took great interest in examining the character of his officers by analyzing the lines on their hands. A chapter of a 17th-century sex manual, misattributed to Aristotle, is occasionally incorrectly cited as being the treatise in question. The text is not contained in his canonical works.

In Renaissance magic, palmistry (known as "chiromancy") was classified as one of the seven "forbidden arts", along with necromancy, geomancy, aeromancy, pyromancy, hydromancy, and spatulamancy (scapulimancy). During the 16th century the art of palmistry was actively suppressed by the Catholic Church. Both Pope Paul IV and Pope Sixtus V issued papal edicts against various forms of divination, including palmistry.

Palmistry experienced a revival in the modern era starting with Captain Casimir Stanislas D'Arpentigny's publication La Chirognomie in 1839. The Chirological Society of Great Britain was founded in London by Katharine St. Hill in 1889 with the stated aim to advance and systematise the art of palmistry and to prevent charlatans from abusing the art. Edgar de Valcourt-Vermont (Comte C. de Saint-Germain) founded the American Chirological Society in 1897.

A pivotal figure in the modern palmistry movement was the Irish William John Warner, known by his sobriquet, Cheiro. After studying under gurus in India, he set up a palmistry practice in London and enjoyed a wide following of famous clients from around the world, including famous celebrities like Mark Twain, W. T. Stead, Sarah Bernhardt, Mata Hari, Oscar Wilde, Grover Cleveland, Thomas Edison, the Prince of Wales, General Kitchener, William Ewart Gladstone, and Joseph Chamberlain. So popular was Cheiro as a "society palmist" that even those who were not believers in the occult had their hands read by him. The skeptical Mark Twain wrote in Cheiro's visitor's book that he had "exposed my character to me with humiliating accuracy".