Dayr Muhaysin (Arabic: دير محيسن, Hebrew: דיר מוחיסין) was a Palestinian village in the Ramle Subdistrict of Mandatory Palestine, located 12 km southeast of Ramla and 4 km west of Latrun. It was depopulated during the 1948 Palestine war.

It has been suggested by the PEF's Survey of Western Palestine that Dayr Muhaysin was one of the Crusader villages which was given by the 12th century King Baldwin V as a fief to the Church of the Holy Sepulchre.

In 1838, it was noted as a Muslim village in the southern part of the Er-Ramleh area.

In 1863, Victor Guérin found a village of some twenty half destroyed and deserted houses, under a large mimosa tree.

The village was mentioned in an official Ottoman village list from around 1870, showing it had 10 houses and a population of 29, though the population count included men only.

In 1883, the "Survey of Western Palestine" found at Dayr Muhaysin: "Traces of a former village; a conspicuous white mound, with cisterns and caves; a large site, also known as Umm esh Shukf."

In the 1931 census of Palestine conducted by the British Mandate authorities, Deir Muheisin had a population of 113; all Muslims, in a total of 28 houses.

In the 1945 statistics, the village had a population of 460 Muslims, while the total land area was 10,008 dunams (equivalent to the Greek stremma or English/American acre), according to an official land and population survey. Of this, 45 dunams were plantations or irrigated, 7,909 for cereals, while 72 dunams were classified as built-up public areas.