Good Luck Chuck is a 2007 romantic comedy film directed by Mark Helfrich, written by Josh Stolberg, and starring Dane Cook and Jessica Alba. In the film, women find their "one true love" after having sex with a dentist named Chuck (Cook). Chuck meets a girl named Cam (Alba) and tries to become her true love.

Good Luck Chuck was the directorial debut of Helfrich, a long-time film editor. The film was released in theaters on September 21, 2007, by Lionsgate, and was widely panned by critics, who criticized the humor and chemistry between Cook and Alba. Despite this, it grossed $59.8 million against a $25 million budget. One of its theatrical posters parodied the well-known Rolling Stone cover photographed by Annie Leibovitz featuring John Lennon and Yoko Ono in similar poses.

While playing spin the bottle / seven minutes in heaven at a party in 1985, 10-year-old Charlie "Chuck" Forrester refuses the sexual advances of a goth girl named Anisha Carpenter. In retaliation, she places a hex on him, saying that once a girl has been with him, "to the next, she will be true".

At present, Chuck is a successful dentist, running a practice in the office opposite his best friend Stu's plastic surgery business. While being sexually intimate with his girlfriend Carol, Chuck cannot reply that he loves her too, prompting her to immediately break up with him.

Stu and Chuck attend the wedding of one of Chuck's ex-girlfriends, Katie. During the reception, she toasts Chuck for being her lucky charm, which gains the interest of his female tablemates. He becomes enamored with Cam Wexler, an unusually clumsy, yet attractive and friendly penguin scientist working at a marine mammal park.

The next day, Chuck's office is full of women. He asks Stu if anything's different about him; they also find that Carol is engaged thanks to Chuck being a lucky charm. His date that evening wants to have sex with him because of the charm, but he gets an emergency call from Cam, who chipped her tooth in a work accident at the penguin exhibit.

Chuck fixes her tooth, but instead of accepting monetary payment, he asks her out for dinner, but Cam declines as she is not emotionally ready. He returns home to find his receptionist Reba coming onto him hoping he will be her lucky charm.

Stu encourages Chuck to indulge in more "guilt-free sex", and he does so. However, he still has feelings for Cam and asks her out. Their relationship deepens, but when Stu calls him and tells him that every single woman Chuck had slept with has gotten married, Chuck gets cold feet and leaves.