Kozani (Greek: Κοζάνη, pronounced [koˈzani]) is a town in northern Greece, capital of Kozani regional unit and of Western Macedonia. It is located in the western part of Macedonia, in the northern part of the Aliakmonas river valley. The city lies 710 metres (2,329 feet) above sea level, 15 kilometres (9 miles) northwest of the artificial lake Polyfytos, 120 km (75 miles) south-west of Thessaloniki, between the mountains Pieria, Vermio, Vourinos and Askio. The population of the Kozani municipality is over 67,000 people. The climate of the area is continental with cold and dry winters, and hot summers.

Kozani is the home of the University of Western Macedonia, with about 15,000 students from all over Greece and other places. It is also the seat of West Macedonia's court of appeal, police department, fire brigade, the seat of the 1st Army Corps of the Hellenic Army and of the Bishop of Servia and Kozani.

One of the most important aspects of local folklore is Kozani's carnival at the end of the winter, which retains much of the profanity of the ancient Dionysiac cult. Kozani is renowned in Greece and abroad for the production of saffron (Krokos Kozanis), in the nearby town of Krokos.

Kozani is a transport node between Central Macedonia, Thessaly and Epirus. The nearest airport is Filippos Airport, 4 kilometres (2 miles) from the city, IATA code: KZI. The airport was first opened in the mid-20th century. Kozani is situated near the A2 motorway, which connects the coast of the Ionian Sea with Thessaloniki and Turkish borders.

According to prevailing opinion in Greece, the name comes from the village of Epirus Kósdiani, the origin of settlers of Kozani in 1392. The settlement was first named Kózdiani, which then, it was changed into Kóziani, and in the end into Kozáni.

Antiquities from the prehistoric to the Byzantine period have been unearthed in many sectors of the city. In the east part of Kozani, an ancient necropolis has been found, dating to the early Iron Age. During Philip II of Macedon's reign, the region was named Elimeia, which was part of Upper Macedonia and probably in the same place there was a town named Tyrissa (Greek: Τύρισσα). In the south-west of the modern city, on Siopoto hill, there was a settlement named Kalyvia, between 1100 and 1300, traces of which are still preserved.

Kozani was probably founded by Christian settlers who, after the Ottoman conquest, withdrew from the plains of Macedonia into the mountains, during the 14th and 15th centuries. Its secure position soon attracted other Christians expelled from Epirus, in 1392. Together with the settlers from Epirus, many cattle-breeders moved in the region.

The first recorded mention of Kozani is in an Ottoman register of 1528, as a settlement with 91 houses, 23 singles and 15 widows. In the Ottoman tahrir defter (number 167) of 1530, the settlement is recorded as a village with the name Kozani, and was within the kaza of Serfice. One of the most important colonizers of Kozani was the chief shepherd Ioannis Trantas, who settled about 100 families. His son, Charisios Trantas, managed to obtain a Sultan's firman in 1664, according to the terms of which the town came under the protection of the Sultan's mother, was endowed with many privileges, and became forbidden for the Turks to settle in.