The Lagoon 380 is a French sailboat that was designed by Van Peteghem/Lauriot-Prevost as a cruiser and also for the yacht charter role. It was first built in 1999.

The design is the best-selling cruising catamaran ever.

The design was built by the Lagoon catamaran division of Jeanneau in France and was the smallest catamaran in their product line. The division was later sold to Construction Navale Bordeaux (CNB) which became part of Groupe Beneteau. Production started in 1999 and the improved Lagoon 380 S2 model was introduced in 2003. Production ran until 2019 with about 1,000 boats completed.

The design was replaced in the line by the Lagoon 40.

The Lagoon 380 is a recreational catamaran, built predominantly of solid polyester fiberglass below the waterline, with portions above the waterline a polyester fiberglass and balsa or foam sandwich. The deck is a balsa sandwich. It has a fractional sloop masthead sloop rig, with a deck-stepped mast, one set of swept diamond spreaders and aluminum spars with continuous stainless steel wire rigging. The twin hulls have nearly plumb stems, reverse transoms with steps and swimming platforms, twin spade rudders controlled by a wheel and twin fixed keels. It displaces 16,005 lb (7,260 kg).

The boat has a draft of 3.77 ft (1.15 m) with the standard twin keels.

The boat is fitted with either two Swedish Volvo or two Japanese Yanmar diesel engines of 20 or 29 hp (15 or 22 kW) for docking and maneuvering. The fuel tank holds 58.2 U.S. gallons (220 L; 48.5 imp gal) and the fresh water tank has a capacity of 79.3 U.S. gallons (300 L; 66.0 imp gal).

A rigid bimini top became a standard item later in production.