Sarah Breedlove married Moses McWilliams at the age of 14. The marriage ended with his death in 1887, leaving her a widow with a young daughter.

Lelia McWilliams was Madam Walker's only child. Their relationship was close, and Lelia played a crucial role in the Walker business, managing operations and later becoming a prominent figure in the Harlem Renaissance. Their bond went beyond mother-daughter, becoming one of business partners.

Sarah married Charles Joseph Walker, who became her business partner and helped her promote and manage her hair care products. The marriage eventually ended in divorce.

Madam Walker developed a friendship with Booker T. Washington, the founder of Tuskegee Institute. She admired his emphasis on vocational training and self-reliance, and she supported his work through donations to the institute.