Messina (/mɛˈsiːnə/ mess-EE-nə, US also /mɪˈ-/ miss-; Italian: [mesˈsiːna] ^ⓘ; Sicilian: Missina [mɪsˈsiːna]; Greek: Μεσσήνη) is a harbour city and the capital of the Italian Metropolitan City of Messina. It is the third largest city on the island of Sicily, and the 13th largest city in Italy, with a population of 216,918 inhabitants in the city proper and 595,948 in the metropolitan city as of 2025. It is located near the northeast corner of Sicily, at the Strait of Messina and it is an important access terminal to Calabria region, Villa San Giovanni, Reggio Calabria on the mainland.

Founded by the Sicels with the name of Zancle in 757 BC, which in their language meant sickle, it was repopulated by Greek colonists of Magna Graecia and renamed Messana. The city was renamed Messina in the Byzantine age. It was an important Roman, and then Greek-Byzantine city, but in 843 it was completely destroyed by the Arabs. Almost abandoned during the Islamic period, it rose again in the Norman era and reached the height of its grandeur between the late Middle Ages and the mid-17th century, when it competed with Palermo for the role of capital of the Kingdom of Sicily.

Put to fire and sword in 1678 after a historic anti-Spanish revolt that led to the annihilation of its ruling class, it was seriously damaged by an earthquake in 1783. In 1908, another earthquake destroyed the city almost entirely, causing the death of about half the population. Rebuilding started in 1912, largely in the Liberty style, and an orderly and regular network of wide and straight streets in a north-south direction was built. Being a strategic target, the city of the strait was heavily bombed by the Allies of World War II in 1943 during the landing in Sicily, being hit by about 6,500 tons of explosives in about 2,800 air raids and four naval bombardments. This event earned the city the Gold Medal of Military Valor. Winston Churchill visited Messina after the bombing. He came to the city in July 1943, during the time when the Allies were executing the invasion of Sicily.

Its port, for thousands of years has been one of the main commercial crossroads of the Mediterranean and only recently becoming a port of call for ferries to the continent, is the first in Italy in terms of number of passengers in transit. According to Eurostat the FUA of the metropolitan area of Messina has, in 2014, 277,584 inhabitants. The city's main resources are its seaports (commercial and military shipyards), cruise tourism, commerce, and agriculture (wine production and cultivating lemons, oranges, mandarin oranges, and olives). The city has been a Roman Catholic Archdiocese and Archimandrite seat since 1548 and is home to a locally important international fair. The city has the University of Messina, founded in 1548 by Pope Paul III.

Founded by Greek colonists of Magna Graecia in the 8th century BC, Messina was originally called Zancle (Ancient Greek: Ζάγκλη), from the Greek ζάγκλον meaning "scythe" because of the shape of its natural harbour (though a legend attributes the name to King Zanclus). A comune of its Metropolitan City, located at the southern entrance of the Strait of Messina, is to this day called 'Scaletta Zanclea'. Solinus wrote that the city of Metauros was established by people from Zancle.

In the early 5th century BC Anaxilas of Rhegium renamed it Messene (Μεσσήνη) in honour of the Greek city Messene (See also List of traditional Greek place names). Later, Micythus was the ruler of Rhegium and Zancle, and he also founded the city of Pyxus. The city was sacked in 397 BC by the Carthaginians and then reconquered by Dionysius I of Syracuse.

In 288 BC the Mamertines seized the city by treachery, killing all the men and taking the women as their wives. The city became a base from which they ravaged the countryside, leading to a conflict with the expanding regional empire of Syracuse. Hiero II, tyrant of Syracuse, defeated the Mamertines near Mylae on the Longanus River and besieged Messina. Carthage assisted the Mamertines because of a long-standing conflict with Syracuse over dominance in Sicily. When Hiero attacked a second time in 264 BC, the Mamertines petitioned the Roman Republic for an alliance, hoping for more reliable protection. Although initially reluctant to assist lest it encourage other mercenary groups to mutiny, Rome was unwilling to see Carthaginian power spread further over Sicily and encroach on Italy. Rome, therefore, entered into an alliance with the Mamertines. In 264 BC, Roman troops were deployed to Sicily, the first time a Roman army acted outside the Italian Peninsula. At the end of the First Punic War it was a free city allied with Rome. In Roman times Messina, then known as Messana, had an important pharos (lighthouse). Messana was the base of Sextus Pompeius, during his war against Octavian.

After the fall of the Western Roman Empire the city was successively ruled by Goths from 476, then by the Byzantine Empire in 535, by the Arabs in 842, and in 1061 by the Norman brothers Robert Guiscard and Roger Guiscard (later count Roger I of Sicily). In 1189 the English King Richard I ("The Lionheart") stopped at Messina en route to the Holy Land for the Third Crusade and briefly occupied the city after a dispute over the dowry of his sister, who had been married to William the Good, King of Sicily.