MicroRNA 203a

MIR203A
Identifiers
Aliases	MIR203A, MIR203, MIRN203, hsa-mir-203a, miR-203, miRNA203, mir-203a, microRNA 203a
External IDs	OMIM: 611899; GeneCards: MIR203A; OMA:MIR203A - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	104,117,514 bp
RNA expression pattern
	Top expressed in
	ectocervix; ; skin of leg; ; left ovary; ; skin of abdomen; ; tibial nerve; ; vagina; ; body of pancreas; ; minor salivary glands; ; monocyte; ; subcutaneous adipose tissue;
	n/a
	More reference expression data
	n/a
Orthologs
	406986
	n/a
	ENSG00000207568
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

MicroRNA 203a is a small RNA that in humans is encoded by the preMIR203A gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000207568 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MicroRNA 203a". Retrieved 2017-07-03.

Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Ståhle M, Pivarcsi A (2007). "MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?". PLOS ONE. 2 (7): e610. Bibcode:2007PLoSO...2..610S. doi:10.1371/journal.pone.0000610. PMC 1905940. PMID 17622355.
Lena AM, Shalom-Feuerstein R, Rivetti di Val Cervo P, Aberdam D, Knight RA, Melino G, Candi E (2008). "miR-203 represses 'stemness' by repressing DeltaNp63". Cell Death Differ. 15 (7): 1187–95. doi:10.1038/cdd.2008.69. PMID 18483491.
Greither T, Grochola LF, Udelnow A, Lautenschläger C, Würl P, Taubert H (2010). "Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival". Int. J. Cancer. 126 (1): 73–80. doi:10.1002/ijc.24687. PMID 19551852.
Sonkoly E, Wei T, Pavez Loriè E, Suzuki H, Kato M, Törmä H, Ståhle M, Pivarcsi A (2010). "Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes". J. Invest. Dermatol. 130 (1): 124–34. doi:10.1038/jid.2009.294. PMID 19759552.
Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J (2010). "miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma". Carcinogenesis. 31 (5): 766–76. doi:10.1093/carcin/bgp250. PMID 19843643.
Melar-New M, Laimins LA (2010). "Human papillomaviruses modulate expression of microRNA 203 upon epithelial differentiation to control levels of p63 proteins". J. Virol. 84 (10): 5212–21. doi:10.1128/JVI.00078-10. PMC 2863797. PMID 20219920.
Ikenaga N, Ohuchida K, Mizumoto K, Yu J, Kayashima T, Sakai H, Fujita H, Nakata K, Tanaka M (2010). "MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma". Ann. Surg. Oncol. 17 (12): 3120–8. doi:10.1245/s10434-010-1188-8. PMID 20652642. S2CID 24422912.
Wei T, Orfanidis K, Xu N, Janson P, Ståhle M, Pivarcsi A, Sonkoly E (2010). "The expression of microRNA-203 during human skin morphogenesis" (PDF). Exp. Dermatol. 19 (9): 854–6. doi:10.1111/j.1600-0625.2010.01118.x. PMID 20698882. S2CID 30026838.
McKenna DJ, McDade SS, Patel D, McCance DJ (2010). "MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6". J. Virol. 84 (20): 10644–52. doi:10.1128/JVI.00703-10. PMC 2950558. PMID 20702634.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000207568 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 203a". Retrieved 2017-07-03.

[1]

[2]

[3]

v t e miRNA precursor families
1-100	1 2 3 5 6 7 8/141/200 9/79 10 11 14 15 16 17 19 21 22 23 24 25 26 28 29 30 31 32 33 34 42 46/47/281 48 52 58 61 62 67 71 84 92 96
101-200	101 103/107 122 124 126 127 129 130 132 133 134 135 137 138 141 143 144 145 146 148/152 150 153 154 155 156 160 166 172 181 184 185 186 187 188 190 191 192/215 193 194 196 198 199 200
201-300	202 203 203a 205 208 210 212 214 216 218 219 221 223 224 241 275 277 278 279 281 282 296 299
301-400	301 305 322 326 330 331 337 338 339 340 344 345 346 350 351 361 363 365 367 370 374 383 384 390 394 395 396 397 398 399
401-500	403 408 423 425 430 431 432 433 434 444 448 449 451 452 454 455 474 484 488 489 491 492 497 498 500
501-600	503 504 505 506 529 535 541 542 544 548 549 550 552 558 562 569 572 575 580 584 589 590 592 598
601+	601 605 612 615 612 612 624 625 632 633 636 638 650 652 657 661 663 671 672 675 708 711 720 744 764 765 767 786 802 824 828 854 872 873 874 885 938 939 3180
Other	BART1 BART2 BHRF1-1 BHRF1-2 BHRF1-3 Let-7 Lin-4 Lsy-6

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