Mechanical music technology is the use of any device, mechanism, machine or tool by a musician or composer to make or perform music; to compose, notate, play back or record songs or pieces; or to analyze or edit music. The earliest known applications of technology to music was prehistoric peoples' use of a tool to hand-drill holes in bones to make simple flutes. Ancient Egyptians developed stringed instruments, such as harps, lyres and lutes, which required making thin strings and some type of peg system for adjusting the pitch of the strings. Ancient Egyptians also used wind instruments such as double clarinets and percussion instruments such as cymbals. In Ancient Greece, instruments included the double-reed aulos and the lyre. Numerous instruments are referred to in the Bible, including the horn, pipe, lyre, harp, and bagpipe. During Biblical times, the cornet, flute, horn, organ, pipe, and trumpet were also used. During the Middle Ages, hand-written music notation was developed to write down the notes of religious Plainchant melodies; this notation enabled the Catholic church to disseminate the same chant melodies across its entire empire.

During the Renaissance music era, the printing press was invented, which made it much easier to mass-produce music (which had previously been hand-copied). This helped to spread musical styles more quickly and across a larger area. During the Baroque era (1600–1750), technologies for keyboard instruments developed, which led to improvements in the designs of pipe organs and harpsichords, and the development of a new keyboard instrument in about 1700, the piano. In the Classical era (1750–1820), Beethoven added new instruments to the orchestra to create new sounds, such as the piccolo, contrabassoon, trombones, and untuned percussion in his Ninth Symphony. During the Romantic music era (c. 1810 to 1900), one of the key ways that new compositions became known to the public was by the sales of relatively inexpensive sheet music, which amateur middle class music lovers would perform at home on their piano or other instruments. In the 19th century, new instruments such as piston valve-equipped cornets, saxophones, euphoniums, and Wagner tubas were added to the orchestra. Many of the mechanical innovations developed for instruments in the 19th century, notably on the piano, brass and woodwinds continued to be used in the 20th and early 21st century.

Findings from paleolithic archaeology sites suggest that prehistoric people used carving and piercing tools to create instruments. Archeologists have found Paleolithic flutes carved from bones in which lateral holes have been pierced. The disputed Divje Babe flute, a perforated cave bear femur, is at least 40,000 years old. Instruments such as the seven-holed flute and various types of stringed instruments, such as the Ravanahatha, have been recovered from the Indus Valley civilization archaeological sites. India has one of the oldest musical traditions in the world—references to Indian classical music (marga) are found in the Vedas, ancient scriptures of the Hindu tradition. The earliest and largest collection of prehistoric musical instruments was found in China and dates back to between 7000 and 6600 BC.

In prehistoric Egypt, music and chanting were commonly used in magic and rituals, and small shells were used as whistles. Evidence of Egyptian musical instruments dates to the Predynastic period, when funerary chants played an important role in Egyptian religion and were accompanied by clappers and possibly the flute. The most reliable evidence of instrument technologies dates from the Old Kingdom, when technologies for constructing harps, flutes and double clarinets were developed. Percussion instruments, lyres and lutes were used by the Middle Kingdom. Metal cymbals were used by ancient Egyptians. In the early 21st century, interest in the music of the pharaonic period began to grow, inspired by the research of such foreign-born musicologists as Hans Hickmann. By the early 21st century, Egyptian musicians and musicologists led by the musicology professor Khairy El-Malt at Helwan University in Cairo had begun to reconstruct musical instruments of Ancient Egypt, a project that is ongoing.

The Indus Valley civilization has sculptures that show old musical instruments, like the seven-holed flute. Various types of stringed instruments and drums have been recovered from Harappa and Mohenjo Daro by excavations carried out by Sir Mortimer Wheeler.

According to the Scriptures, Jubal was the father of harpists and organists (Gen. 4:20–21). The harp was among the chief instruments and the favorite of David, and it is referred to more than fifty times in the Bible. It was used at both joyful and mournful ceremonies, and its use was "raised to its highest perfection under David" (1 Sam. 16:23). Lockyer adds that "It was the sweet music of the harp that often dispossessed Saul of his melancholy (1 Sam. 16:14–23; 18:10–11). When the Jews were captive in Babylon they hung their harps up and refused to use them while in exile, earlier being part of the instruments used in the Temple (1 Kgs. 10:12). Another stringed instrument of the harp class, and one also used by the ancient Greeks, was the lyre. A similar instrument was the lute, which had a large pear-shaped body, long neck, and fretted fingerboard with head screws for tuning. Coins displaying musical instruments, the Bar Kochba Revolt coinage, were issued by the Jews during the Second Jewish Revolt against the Roman Empire of 132–135 AD.

In addition there was the psaltery, another stringed instrument which is referred to almost thirty times in Scripture. According to Josephus, it had twelve strings and was played with a quill, not with the hand. Another writer suggested that it was like a guitar, but with a flat triangular form and strung from side to side.

Among the wind instruments used in the biblical period were the cornet, wood flute, horn, organ, pipe, and early trumpet. There were also silver trumpets and the double oboe. Werner concludes that from the measurements taken of the trumpets on the Arch of Titus in Rome and from coins, that "the trumpets were very high pitched with thin body and shrill sound." He adds that in War of the Sons of Light Against the Sons of Darkness, a manual for military organization and strategy discovered among the Dead Sea Scrolls, these trumpets "appear clearly capable of regulating their pitch pretty accurately, as they are supposed to blow rather complicated signals in unison." Whitcomb writes that the pair of silver trumpets were fashioned according to Mosaic law and were probably among the trophies which the Emperor Titus brought to Rome when he conquered Jerusalem. She adds that on the Arch raised to the victorious Titus, "there is a sculptured relief of these trumpets, showing their ancient form. (see photo)