The Paleogene Period (IPA: /ˈpeɪli.ədʒiːn, -li.oʊ-, ˈpæli-/ PAY-lee-ə-jeen, -⁠lee-oh-, PAL-ee-; also spelled Palaeogene or Palæogene) is a geologic period and system that spans 43 million years from the end of the Cretaceous Period 66 Ma (million years ago) to the beginning of the Neogene Period 23.04 Ma. It is the first period of the Cenozoic Era, the tenth period of the Phanerozoic and is divided into the Paleocene, Eocene, and Oligocene epochs. The earlier term Tertiary Period was used to define the time now covered by the Paleogene Period and subsequent Neogene Period; despite no longer being recognized as a formal stratigraphic term, "Tertiary" still sometimes remains in informal use. Paleogene is often abbreviated "Pg", although the United States Geological Survey uses the abbreviation "Pe" for the Paleogene on the Survey's geologic maps.

Much of the world's modern vertebrate diversity originated in a rapid surge of diversification in the early Paleogene, as survivors of the Cretaceous–Paleogene extinction event took advantage of empty ecological niches left behind by the extinction of the non-avian dinosaurs, pterosaurs, marine reptiles, and primitive fish groups. Mammals continued to diversify from relatively small, simple forms into a highly diverse group ranging from small-bodied forms to very large ones, radiating into multiple orders and colonizing the air and marine ecosystems by the Eocene. Birds, the only surviving group of dinosaurs, quickly diversified from the very few neognath and paleognath clades that survived the extinction event, also radiating into multiple orders, colonizing different ecosystems and achieving an extreme level of morphological diversity. Percomorph fish, the most diverse group of vertebrates today, first appeared near the end of the Cretaceous but saw a very rapid radiation into their modern order and family-level diversity during the Paleogene, achieving a diverse array of morphologies.

The Paleogene is marked by considerable changes in climate from the Paleocene–Eocene Thermal Maximum, through global cooling during the Eocene to the first appearance of permanent ice sheets in the Antarctic at the beginning of the Oligocene.

The Paleogene is divided into three series/epochs: the Paleocene, Eocene, and Oligocene. These stratigraphic units can be defined globally or regionally. For global stratigraphic correlation, the International Commission on Stratigraphy (ICS) ratify global stages based on a Global Boundary Stratotype Section and Point (GSSP) from a single formation (a stratotype) identifying the lower boundary of the stage.

The Paleocene is the first series/epoch of the Paleogene and lasted from 66.0 Ma to 56.0 Ma. It is divided into three stages: the Danian 66.0 - 61.6 Ma; Selandian 61.6 - 59.2 Ma; and, Thanetian 59.2 - 56.0 Ma. The GSSP for the base of the Cenozoic, Paleogene and Paleocene is at Oued Djerfane, west of El Kef, Tunisia. It is marked by an iridium anomaly produced by an asteroid impact, and is associated with the Cretaceous–Paleogene extinction event. The boundary is defined as the rusty colored base of a 50 cm thick clay, which would have been deposited over only a few days. Similar layers are seen in marine and continental deposits worldwide. These layers include the iridium anomaly, microtektites, nickel-rich spinel crystals and shocked quartz, all indicators of a major extraterrestrial impact. The remains of the crater are found at Chicxulub on the Yucatan Peninsula in Mexico. The extinction of the non-avian dinosaurs, ammonites and dramatic changes in marine plankton and many other groups of organisms, are also used for correlation purposes.

The Eocene is the second series/epoch of the Paleogene, and lasted from 56.0 Ma to 33.9 Ma. It is divided into four stages: the Ypresian 56.0 Ma to 47.8 Ma; Lutetian 47.8 Ma to 41.2 Ma; Bartonian 41.2 Ma to 37.71 Ma; and, Priabonian 37.71 Ma to 33.9 Ma. The GSSP for the base of the Eocene is at Dababiya, near Luxor, Egypt and is marked by the start of a significant variation in global carbon isotope ratios, produced by a major period of global warming. The change in climate was due to a rapid release of frozen methane clathrates from seafloor sediments at the beginning of the Paleocene-Eocene thermal maximum (PETM).

The Oligocene is the third and youngest series/epoch of the Paleogene, and lasted from 33.9 Ma to 23.03 Ma. It is divided into two stages: the Rupelian 33.9 Ma to 27.82 Ma; and, Chattian 27.82 - 23.03 Ma. The GSSP for the base of the Oligocene is at Massignano, near Ancona, Italy. The extinction of the hantkeninid planktonic foraminifera is the key marker for the Eocene-Oligocene boundary, which was a time of climate cooling that led to widespread changes in fauna and flora.

The final stages of the breakup of Pangaea occurred during the Paleogene as Atlantic Ocean rifting and seafloor spreading extended northwards, separating the North America and Eurasian plates, and Australia and South America rifted from Antarctica, opening the Southern Ocean. Africa and India collided with Eurasia forming the Alpine-Himalayan mountain chains and the western margin of the Pacific plate changed from a divergent to convergent plate boundary.