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Polysyndactyly
Polysyndactyly
Polysyndactyly
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Polysyndactyly
Foot polysyndactyly
SpecialtyMedical genetics

Polysyndactyly is a congenital anomaly, combining polydactyly and syndactyly, in which affected individuals have an extra finger or toe that is connected, via fusing or webbing, to an adjacent digit.[1][2]

Signs and symptoms

[edit]

Presentations of polysyndactyly vary in location and size of the duplicated digit, and in the extent of webbing between digits.[2][3][4]

The extra digit is most commonly postaxial,[5] on the same side as the pinky or little toe.[3] Preaxial polysyndactyly, in which the duplicated digit is on the side of the thumb or big toe, is less common.[3] Crossed polysyndactyly, in which polysyndactyly is present on the hand and foot, and is preaxial on one and postaxial on the other, is extremely rare and often occurs with other genetic disorders.[6]

Polysyndactyly may be classified by the level of duplication. The extra digit may be small and comprise only soft tissue,[7] but usually includes at least one bone, most commonly the distal and middle phalanges.[4][8] Partial or complete duplication of the proximal phalanx, metacarpal or metatarsal can also occur.[4][7]

Fusing of the extra digit may be incomplete,[4] giving the appearance of the extra digit being partially connected to the (otherwise normal) adjacent digit. However, complete fusion of the extra digit to the adjacent digit, via soft tissue and skin, is more common.[4]

Causes

[edit]

Polysyndactyly is typically inherited, in an autosomal dominant pattern.[2][6][9] The specific mutations leading to polysyndactyly are varied between among types of the condition and different families. However, many cases are caused by changes to genetic elements affecting the signaling molecule Sonic Hedgehog (SHH). Primarily, mutations are found in the zone of polarizing activity regulatory sequence, or ZRS, that controls the expression of SHH in developing limbs. Many cases of polysyndactyly are the result of duplications of the ZRS[10][11][12] or the nearby pre-ZRS region.[13][14]

Polysyndactyly can be associated with the presence of other genetic disorders. It is a hallmark of Carpenter's syndrome, an autosomal recessive disorder that is also associated with craniosynostosis, obesity, short stature, and other malformations.[15] Patients with other syndromes, including Pallister-Hall syndrome[16] and Greig cephalopolysyndactyly syndrome[17] may also display polysyndactyly of varying severity.

Polysyndactyly has full penetrance but variable expressivity; individuals who possess an allele for polysyndactyly may have a different severity of the condition. This has been seen in case studies where a parent has hexadactyly in their 4th and 5th fingers but their child has hexadactyly in their 1st, 2nd, 3rd and 4th fingers.[18]

Diagnosis

[edit]

Polysyndactyly can be diagnosed in utero through sonographic and genetic testing, though sonography may be preferred due to the cost and risk associated with genetic testing.[19] Ultrasounds, typically done at the 14th to 16th week of pregnancy, can detect the presence of extra metacarpals, metatarsals, or phalanges.[19][20] Genetic testing of the fetus examines disruptions in the HOXD13 gene at 2q31-q32 and in the GLI3 gene at 7p13. These genomic regions regulate proliferation and differentiation in the limb bud, and can lead to phenotypic anomalies, including polysyndactyly, if mutated. Postnatally, polysyndactyly is diagnosed by observation of an extra digit and X-rays to confirm the presence of an extra metacarpal, metatarsal, or phalanx.[19][21]

Treatment and Prognosis

[edit]

Polysyndactyly is treated through surgical excision of the extra digit. The choice of which digit to remove affects post-operative outcomes; factors that must be considered when determining which digit to excise include the neurovascular bundles, angle differences, risks for impaired circulation, post-operative appearance, and residual deformities.[5][7]

Treatment is generally aimed at normalizing both function and appearance of the affected extremity[3] and, in the case of polysyndactyly of the foot, shoe fit and comfort.[22] The underlying cause of polysyndactyly determines the overall quality of life for individuals diagnosed with this condition. If there are no comorbid or underlying genetic conditions, surgical removal of the extra digit generally results in a high quality of life. Parents of children with polysyndactyly have reported high physical, social, emotional, and school functioning and good psychosocial health after removal of the extra digit.[23]

References

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Polysyndactyly

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from Grokipedia
Polysyndactyly is a congenital limb malformation characterized by the presence of one or more extra digits () that are fused or webbed to adjacent digits (), typically affecting the hands or feet. This condition combines elements of both , the most common congenital hand anomaly with an incidence of approximately 1 in 1,000 live births, and , where digits fail to separate during embryonic development. It most frequently manifests as preaxial type IV (PPD4), involving mild duplication of the thumb alongside between the third and fourth fingers, and often more pronounced involvement of the feet with duplication and fusion of the hallux or second toe. The etiology of polysyndactyly is primarily genetic, with autosomal dominant inheritance patterns observed in isolated cases. Mutations in the GLI3 gene, located on chromosome 7p14.1, are a well-established cause, disrupting sonic hedgehog (SHH) signaling pathways critical for limb patterning during embryogenesis. Additionally, alterations in the ZRS of the SHH gene have been implicated, leading to variable expressivity and potential triphalangeal thumbs or broad bifid structures. When associated with broader syndromes, polysyndactyly may appear alongside craniofacial anomalies, cardiac defects, or , as seen in conditions like or polysyndactyly-cardiac malformation syndrome. Diagnosis is typically made at birth through and such as radiographs to assess structure and fusion extent. Treatment is surgical, often involving digit separation and reconstruction in infancy to optimize function and , with procedures tailored to the of the fusion and duplication. Outcomes are generally favorable with early intervention, though cosmetic and functional challenges may persist in syndromic cases.

Overview

Definition

Polysyndactyly is a congenital limb anomaly characterized by the presence of supernumerary digits () that are fused or webbed with adjacent digits (), typically affecting the hands or feet. This condition arises during embryonic development and represents a combined malformation, distinct from isolated or , where extra digits occur without fusion or digits fuse without extras. The term "polysyndactyly" derives from the Greek roots "poly-" meaning many, referring to the multiple digits, and "syndactyly," which combines "syn-" (together) and "daktylos" (finger or digit), denoting the fusion aspect. It was first described in medical literature in the context of syndromic presentations in the early 20th century, such as in Greig cephalopolysyndactyly syndrome reported in 1926. Anatomically, the fusion in polysyndactyly may involve only soft tissues (simple syndactyly) or extend to bony elements (complex syndactyly), with the extra digit often sharing a common skin envelope or exhibiting partial osseous union. Supernumerary digits in polydactyly are most commonly postaxial, located on the ulnar (little finger) or fibular (little toe) side; however, polysyndactyly most frequently involves preaxial forms, such as PPD IV on the thumb or hallux side, though postaxial, central, or other positions can occur. Although rare in humans, polysyndactyly-like traits are observed in animal models, including cats, llamas, and chickens, providing insights into limb development studies.

Polysyndactyly is classified anatomically based on the location of the duplicated digits, which can be preaxial (on or great toe side), postaxial (on the little finger or little toe side), central (involving middle digits), or mirror-image (symmetrical duplications on both sides of the hand or foot). This system aids in standardizing descriptions and guiding management, as preaxial forms often involve the first ray and may require more complex reconstruction due to functional importance of or hallux. The extent of in polysyndactyly is categorized as simple, involving only connections without bony fusion, or complex, featuring osseous unions between duplicated digits; additionally, it is described as complete if the fusion extends the full length of the digits or incomplete if limited to partial . These distinctions are critical for assessing the degree of malformation and planning interventions, with complex forms typically presenting greater challenges due to abnormal skeletal architecture. Polysyndactyly manifests in both hands and feet, though isolated components are more prevalent in hands overall; in the feet, postaxial polysyndactyly predominates and frequently includes metatarsal duplications, leading to widened forefoot structures. The American Society for Surgery of the Hand endorses classifications that integrate these features within the broader Swanson system for congenital upper extremity anomalies, emphasizing radiographic evaluation to confirm digit involvement and fusion patterns for precise . Polysyndactyly can occur in isolation or as part of syndromes, such as , where cutaneous affects up to 75% of cases, typically partial but occasionally with phalangeal fusions, distinguishing it from nonsyndromic forms.

Epidemiology

Prevalence

Polysyndactyly, characterized by the presence of extra digits that are fused with adjacent ones, is a subtype of and combined, occurring rarely in isolation or as part of syndromes. Specific prevalence data for polysyndactyly is limited, but it is estimated to be lower than general rates, often less than 1 per 10,000 births. The overall incidence of , of which polysyndactyly forms a subset, is approximately 0.3 to 3.6 per 1,000 live births globally, equating to 1 in 278 to 1 in 3,333 newborns. Geographic and ethnic variations significantly influence the occurrence of polydactyly and its subtypes like polysyndactyly. Rates are higher among African and African-American populations, reaching up to 10-13 per 1,000 live births (or 1 in 100 to 1 in 300) for polydactyly forms. Indigenous populations, such as Native Americans, show rates approximately twice those of Caucasians, at about 2.4 per 1,000 live births. In comparison, rates are lower at 0.3-1.6 per 1,000 (or 1 in 625 to 1 in 3,333) in Caucasian groups. These disparities are documented in population-based studies, with EUROCAT registries reporting average polydactyly prevalence of 5.7-8.4 per 10,000 births (0.57-0.84 per 1,000) across European regions. In terms of distribution, hands are affected more commonly than feet in cases, including polysyndactyly. Bilateral involvement occurs in about 50% of cases, particularly in familial or syndromic presentations. The incidence of polysyndactyly has remained stable over time, with no significant temporal trends observed in surveillance data from the onward. However, prenatal detection has improved since the due to advancements in imaging, allowing identification in approximately 20-40% of cases in high-resource settings. Key data derive from ongoing birth defects surveillance by the Centers for Disease Control and Prevention (CDC) in the United States and the European Surveillance of Congenital Anomalies (EUROCAT) network, which monitor over 1.5 million births annually across multiple countries to track such anomalies.

Risk Factors

Polysyndactyly exhibits a strong , with a positive history identified as the strongest risk factor. In cases of foot polysyndactyly, approximately 30% demonstrate , often following an autosomal dominant pattern with variable and expressivity. This inheritance mode is supported by genetic studies showing mutations in genes such as GLI3, which underlie both isolated and syndromic forms. Certain ethnic groups show elevated risks, particularly for postaxial forms of that may include . Among , the incidence of postaxial polydactyly is approximately 10 times higher than in individuals of European descent, occurring in about 1 in 143 newborns. Native American populations also exhibit a higher overall incidence of polydactyly, estimated at twice the rate seen in Caucasians, or about 2.4 per 1,000 live births. Maternal factors during pregnancy contribute to increased risk. Advanced maternal age greater than 35 years is associated with a higher likelihood of , including forms with , with an of 1.27 compared to mothers aged 25-29 years. Similarly, pregestational maternal significantly elevates the risk, with a of 1.98 for or in offspring. Teratogenic exposures, though rare, have been linked to polysyndactyly. exposure during early pregnancy can induce limb malformations including with , as observed in historical cohorts of affected infants. Certain medications, such as , are also associated with increased risk of postaxial , potentially compounded by in some cases. A notable proportion of polysyndactyly cases, estimated at 15-20%, occur as part of broader genetic syndromes rather than in isolation. These associations underscore the importance of evaluating for syndromic features when polysyndactyly is identified.

Pathophysiology

Genetic Mechanisms

Polysyndactyly is primarily inherited in an autosomal dominant manner with variable , often ranging from 50% to 90% depending on the specific genetic variant and population studied. Rare forms exhibit autosomal recessive inheritance, particularly in association with certain syndromic conditions involving additional malformations. Key genes implicated in polysyndactyly include GLI3, which underlies through heterozygous loss-of-function mutations, associated with synpolydactyly type 1, and the ZRS enhancer region regulating SHH expression, where duplications lead to ectopic SHH signaling and preaxial polysyndactyly. At the molecular level, these mutations dysregulate the Sonic Hedgehog (SHH) signaling pathway, which plays a in anterior-posterior limb patterning during embryonic development; this dysregulation promotes extra digit formation by altering mesenchymal proliferation and inhibiting interdigital necessary for digit separation. Specific examples of pathogenic variants include point mutations in GLI3, such as nonsense or frameshift changes that truncate the protein and impair its repressor function in the SHH pathway, and expansions in the polyalanine tract of (typically adding 7 or more alanine residues), which disrupt homeodomain-mediated transcription regulation. In the ZRS enhancer, small duplications or point mutations cause aberrant SHH expression in the anterior limb bud, resulting in duplicated preaxial structures fused with . Genetic testing, particularly targeted sequencing of candidate genes like GLI3, , and the SHH-ZRS locus, is recommended for confirmation in familial cases to identify causative variants and inform counseling on recurrence risks.

Developmental Biology

Limb development in humans occurs primarily between the fourth and eighth weeks of , beginning with the appearance of buds around day 26 post-fertilization, followed by lower limb buds two days later. During this period, the apical ectodermal ridge (AER), a thickened ectodermal structure at the distal limb bud margin, secretes growth factors (FGFs) to promote proximodistal outgrowth and patterning. Complementing this, the zone of polarizing activity (ZPA), located in the posterior , directs anteroposterior axis formation via Sonic hedgehog (SHH) signaling from the ZPA, which specifies digit identity and number. Polysyndactyly disrupts key embryological processes in digit formation and separation. Syndactyly, the fusion of digits, stems from impaired interdigital necrosis, a form of (apoptosis) mediated by (BMP) signaling, which normally sculpts interdigital spaces. This failure typically occurs during weeks 7 to 8, when mesenchymal tissue between nascent digits undergoes selective degeneration. Conversely, polydactyly, involving extra digits, arises from SHH overexpression or ectopic activity in the ZPA, disrupting the precise timing and spatial regulation of digit ray specification around week 6. SHH acts as a in this context, with its concentration gradients determining digit patterning along the anteroposterior axis. Animal models provide critical insights into these disruptions. For instance, mice with Gli3 mutations, such as the extra-toes (Xt) or doublefoot (Dbf) strains, display combined with due to dysregulated SHH-Gli3 interactions, resulting in broadened limb buds and supernumerary triphalangeal digits that human polysyndactyly. These models highlight how Gli3 repressors normally limit SHH diffusion to prevent excess digit formation. Although primarily genetic, rare non-genetic factors can contribute to polysyndactyly-like anomalies. Vascular disruptions during early may impair mesenchymal cell survival in regions, hindering and leading to soft tissue . Similarly, amniotic band syndrome, involving entangling fibrous strands from the amniotic sac, can constrict developing limbs around weeks 6 to 8, mimicking or causing irregular digit fusion through mechanical interference.

Clinical Features

Signs and Symptoms

Polysyndactyly is characterized by the presence of supernumerary digits that are fused to adjacent digits through or bony , most commonly affecting the preaxial region of the hands and feet. It is often classified as preaxial type IV (PPD4), with the extra digit typically arising from duplication of phalanges or metacarpals/metatarsals, showing variable degrees of bone involvement from fully formed structures to partial duplications such as bifid or broad thumbs. These manifestations are evident at birth and do not progress significantly postnatally. In the hands, polysyndactyly typically presents as mild duplication of the (preaxial, radial side), often with radial deviation, broad or bifid structure, and between the third and fourth fingers. The duplicated may exhibit duplicated or triphalangeal phalanges in some cases, and nail abnormalities such as hypoplastic, duplicated, or ridged nails are common on the extra or affected digits. Presentation can vary by factors, with possible preaxial forms showing thumb duplication alongside . Foot involvement typically affects the preaxial or central regions, with duplication and fusion of the hallux (big toe) or second toe, often leading to partial or complete and duplicated metatarsals or phalanges, accompanied by tibial deviation or a short first metatarsal. This fusion can cause misalignment, contributing to difficulties with shoe fitting or uneven weight distribution. Functionally, polysyndactyly in the hands may result in reduced dexterity and due to limited in the fused digits, particularly in severe cases with complete . In the feet, it can lead to mild abnormalities or balance issues from altered foot architecture, though pain is rare unless secondary complications like ulceration occur.

Associated Syndromes

Polysyndactyly serves as a cardinal feature in several genetic syndromes, distinguishing them from isolated limb malformations. These conditions typically involve multi-system anomalies and are associated with specific gene mutations, often within signaling pathway, including GLI3 involvement. (GCPS) is an autosomal dominant disorder caused by heterozygous mutations in the GLI3 gene on 7p14.1. It is characterized by postaxial or syndactylous of the hands and feet, often with partial duplication and fusion of digits, accompanied by , , and mild in some cases. Diagnostic criteria include the presence of polysyndactyly with craniofacial features, as outlined in clinical descriptions. Pallister-Hall syndrome (PHS) results from truncating mutations in GLI3, leading to central polysyndactyly—typically involving of digits 3 and 4 with an extra digit arising from the central metacarpal or metatarsal. Additional hallmarks include hypothalamic hamartomas, postaxial polydactyly, bifid epiglottis, and , with variable severity. The syndrome follows autosomal dominant inheritance, and diagnosis relies on the combination of and limb anomalies. Carpenter syndrome, or acrocephalopolysyndactyly type II, is an autosomal recessive condition due to biallelic mutations in the RAB23 gene on chromosome 19q13.2. It features preaxial and of the hands and feet, often with and broad thumbs or halluces, alongside , , and . Partial or complete of toes is common, and the syndrome is distinguished by its association with cardiac and visceral anomalies in some individuals. Acrocallosal syndrome (ACLS) is caused by biallelic mutations in the KIF7 gene on chromosome 15q26.1, presenting with preaxial and postaxial of the hands and feet, hallux duplication, and . Key associated features include or of the , , , and profound . The condition exhibits autosomal recessive inheritance, with diagnosis based on the limb and brain malformations. Diagnostic criteria for these disorders are detailed in the OMIM database.

Diagnosis

Prenatal Diagnosis

Prenatal diagnosis of polysyndactyly primarily relies on imaging and, in select cases, invasive to detect limb malformations during . Routine fetal scans performed between 18 and 20 weeks of gestation can identify extra digits and by visualizing more than five digits on the hands or feet in coronal and axial planes, often confirming the presence of bony phalanges. Three-dimensional ( enhances detailed assessment, particularly for digit counting and evaluating extent, improving visualization when two-dimensional imaging is inconclusive. In high-risk pregnancies, such as those with family history, anomalies may be detectable as early as 12 to 14 weeks, though the second trimester remains optimal for reliable identification. Detection sensitivity for major via prenatal varies, with studies reporting rates of approximately 19% for and up to 42% for related anomalies during routine screening, though specificity is high and increases with targeted 3D evaluation. Lower sensitivity often stems from subtle or soft-tissue-only extra digits, while more pronounced cases like those involving are more readily identified. Upon suspicion of polysyndactyly, a comprehensive should assess for associated features, such as craniofacial or thoracic anomalies, to guide further testing. For high-risk families, via (CVS) at 10-13 weeks or at 15-20 weeks is recommended, targeting panels that include genes like GLI3 (associated with ), HOXD13 (linked to synpolydactyly), and SHH regulatory elements (ZRS enhancer). These tests, often using or whole-exome sequencing, confirm molecular etiologies and inform recurrence risks, which range from 25% in autosomal recessive forms to 50% in dominant inheritance patterns. Post-detection, multidisciplinary counseling involving geneticists, obstetricians, and pediatric specialists is essential to discuss , associated syndromes, and options, emphasizing that isolated polysyndactyly often carries a favorable outcome with low recurrence if sporadic.

Postnatal Evaluation

Following birth, postnatal evaluation of polysyndactyly begins with a thorough to confirm the presence of extra digits and associated , typically affecting the hands or feet. This assessment involves inspecting the number of digits, the extent of fusion (simple or complex, complete or incomplete), and evaluating mobility, , and any associated or nail abnormalities. The examination also checks for syndromic features, such as craniofacial anomalies or other limb involvement, to guide further testing. Imaging studies are essential to delineate the underlying skeletal architecture. Plain radiographs (X-rays) are the initial modality of choice, revealing bony duplications such as extra phalanges, metacarpals, or metatarsals, as well as the degree of fusion between digits. In complex cases involving significant soft tissue involvement or unclear bony connections, (MRI) may be employed to better visualize tendons, ligaments, and neurovascular structures. If syndromic features are evident, genetic evaluation is pursued to identify underlying causes. Karyotyping or chromosomal microarray analysis can detect duplications or deletions, such as those on 7q or 13q associated with polysyndactyly subtypes. Targeted gene sequencing for mutations in genes like GLI3, ZRS, or is recommended, particularly in familial or syndromic presentations. Evaluation typically involves a multidisciplinary team, including pediatricians for overall assessment, geneticists for molecular testing, and orthopedic or hand surgeons for structural analysis and future planning. This collaborative approach ensures comprehensive care, correlating any prenatal findings with postnatal observations if available. Differential diagnosis includes distinguishing polysyndactyly from isolated , which lacks fusion, and amniotic band syndrome, characterized by irregular constrictions, amputations, or acrosyndactyly without symmetric duplications. Clinical history, imaging patterns, and absence of amniotic bands on exam help differentiate these conditions.

Management

Surgical Interventions

Surgical interventions for polysyndactyly aim to address both digit duplication and through excision and reconstructive techniques, guided briefly by systems that determine the extent of duplication and fusion. Timing is selected to minimize risks while allowing initial growth; hand surgeries are typically performed between 6 and 12 months of age, whereas foot procedures are often delayed to 1-2 years to support developing capabilities. Core procedures involve excision of the supernumerary digit, release to reconstruct interdigital webbing, and osteotomies for correcting associated bony deformities such as divergent or Y-shaped metatarsals or metacarpals. Local flaps, including dorsal and volar designs, provide skin coverage, with full-thickness grafts sourced from areas like the or sinus tarsi if additional tissue is required; one-stage corrections combining and release are common to reduce exposures. In hand surgeries, meticulous preservation of neurovascular structures is essential, often involving microsurgical dissection to maintain sensation and in the reconstructed digit; tendons or ligaments from the excised portion may be transferred to the primary ray to optimize opposition and stability. Foot interventions prioritize metatarsal alignment and arcade reconstruction for balanced , with reserved for rudimentary or non-functional elements to avoid growth disturbances. Potential complications include (rates around 1-2%) and postoperative or (affecting up to 10-20% of cases), with reoperation needed in approximately 7-28% for residual deformities; overall, functional outcomes achieve good to excellent results in 85-95% of patients per validated scoring systems.

Prognosis

The prognosis for polysyndactyly is generally favorable following surgical correction, with most patients achieving good functional and cosmetic outcomes. In cases of isolated polysyndactyly, approximately 88% of patients report satisfaction or high satisfaction with functional results after thumb reconstruction, enabling near-normal hand use for daily activities. For foot polysyndactyly, surgical intervention leads to significant improvements in forefoot alignment and width without postoperative pain or functional deficits, enhancing stability in the majority of cases. Cosmetic outcomes are also highly satisfactory, with patients rating hand appearance improvements at a median of 4 out of 5 and overall aesthetic scores averaging 3.3 out of 4 in reconstructed cases. However, revisions may be required in 10-20% of cases due to growth-related deformities or residual issues, particularly as patients age into . In syndromic forms, such as Pallister-Hall syndrome, the prognosis is poorer when neurological or cardiac comorbidities are present, with potential for life-threatening complications like undiagnosed leading to neonatal mortality if untreated. Quality of life remains largely unaffected in isolated cases treated early, with minimal psychological impacts such as stress or low reported in less than 60% of children, often mitigated through timely intervention and follow-up care extending into adolescence. Recent advances in surgical techniques since the , including refined flap designs and gradation , have reduced recurrence rates to under 5% and improved overall satisfaction by minimizing scarring and complications.

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