Rusholme (/ˈrʌʃoʊm/) is an area of Manchester, in Greater Manchester, England, two miles south of the city centre. The population of the ward at the 2011 census was 13,643. Rusholme is bounded by Chorlton-on-Medlock to the north, Victoria Park and Longsight to the east, Fallowfield to the south and Moss Side to the west. It has a large student population, with several student halls and many students renting terraced houses, and suburban houses towards Victoria Park.

Rusholme, unlike other place names in Manchester with the suffix ‑hulme/holme is not a true water meadow. Its name derives from ryscum, the dative plural of the Old English rysc, a "rush" meaning at the rushes. The name was recorded as Russum in 1235, Ryssham in 1316 and Rysholme in 1551.

Late in the Roman occupation of Britain, a hoard of about 200 gold coins was hidden in the valley of the Gore Brook. These date from the 2nd and 3rd centuries CE and were found where Birchfields Road crosses the brook in the 1890s. They are now held in the Manchester Museum.

The name Rusholme first appears in the mid-13th century, when "Russum" is mentioned. A house is known to have existed at Platt at that time, which was replaced by a larger one of black-and-white construction. This remained the home of the Platts until the present classical building replaced it in the mid-18th century. An early record of the Platt estate mentions the Nico Ditch, an 8th or 9th-century Anglo-Saxon linear earthwork running east–west through the area and probably marking an administrative boundary. Tales of battles between Danes and Normans associated with the road names Danes Road and Norman Road are not accepted by historians. Another black-and-white hall at Birch was probably built in the 16th century.

The economy of the area was dependent on agriculture until the 18th century; however during the 17th and 18th centuries there was a growth of cottage industries such as spinning, weaving and brickmaking.

Over the Victorian era, there were several different socio-political meanings of Rusholme. Primarily, it was a township based around a general area known as Rusholme since at least the 13th century. The area grew into a township, and by the beginning of the 19th century, it had its own government responsible for public health, roads, policing, poor relief, and other local government tasks. Rusholme was originally a politically autonomous entity, which was vital to its self-conception as a discrete area even after its incorporation into Manchester. Low-cost terraced housing built between 1880 and 1930 dominates the landscape, along with a sprawling council housing estate from the interwar period.

Richard Cobden, William Royle (author of a history of the township), and Thomas Lowe (1815–1892) were long-time residents. Lowe began working as a baker and became a flour dealer, later a nurseryman and finally the proprietor of a dairy. Prime Minister H. H. Asquith was married here in 1877 to Miss Helen Melland.

The Conservative Dame Kathleen Ollerenshaw was for 26 years one of the councillors for Rusholme on Manchester City Council, before becoming Lord Mayor of Manchester in 1975–1976. Other local politicians included ward councillor Paul Shannon, a Liberal Democrat and former deputy leader of the Manchester City Council Liberal Democrat group who was defeated by Ahmed Ali (Labour) in May 2012. Rabnawaz Akbar was elected as a Labour councillor for Rusholme ward in May 2010. Councillor Akbar served on the Citizenship and Inclusion Committee.