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Selsun Blue
Selsun Blue
Selsun Blue
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Selsun Blue is an over-the-counter brand of dandruff shampoo now owned by Opella (formerly Sanofi Consumer Healthcare). Made by Abbott Laboratories, the brand was later bought by Chattem in 2002. Chattem was acquired by Sanofi in 2010, although in some markets, it is sold by Rohto Pharmaceutical instead. Selsun Blue has been marketed as a more effective alternative to brand leader Head & Shoulders due to its superior performance in randomized trials.[1]

Formulations

[edit]

Over the counter Selsun Blue contains 1% selenium sulfide as its active ingredient in its most popular version[2] (the word "Selsun" is a portmanteau of selenium sulfide + n). Chattem announced that on November 1, 2005, they would introduce a new line of shampoos under the brand name Selsun Salon. These contained a different active ingredient than Selsun Blue, pyrithione zinc 1%, and are oriented toward the higher-end shampoo market. Other active ingredients such as salicylic acid and botanicals are in other versions of Selsun Blue brand dandruff shampoo.

In 2011, the Selsun Blue brand consisted of 15 products spread across two brand segments, Naturals and Base. The Naturals line of products contains the active ingredient salicylic acid in addition to 8 moisturizers & botanicals plus vitamins B5 & E. Salicylic acid is a keratolytic agent that assists with cell shedding or flaking.[3] The base brand consists of six types including Medicated with menthol, 2-in-1, Normal to Oily, Moisturizing, Itchy Dry Scalp, and Deep Cleansing with micro beads.[4] The first four types contain the active ingredient selenium sulfide which has been shown to have anti-fungal properties. More specifically, selenium sulfide, an anti-infective agent, relieves itching and flaking of the scalp and removes the dry, scaly particles commonly referred to as dandruff or seborrhea. Selenium sulfide is also used to treat tinea versicolor, a fungal infection of the skin.[5]

Deep Cleansing was launched by Chattem in January 2011. In addition to the active ingredient salicylic acid, the product touts itself as containing scrubbing micro beads.[clarification needed]

Availability

[edit]

Like Chattem’s other products, Selsun Blue is sold through mass merchandisers, drug and food retailers.

References

[edit]
[edit]
Revisions and contributorsEdit on WikipediaRead on Wikipedia

Selsun Blue

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from Grokipedia
Selsun Blue is an over-the-counter brand of medicated primarily used to control , seborrheic dermatitis, and associated scalp symptoms such as itching, flaking, irritation, and redness. Its core formulations feature 1% as the , an agent that targets the yeast responsible for these conditions while also slowing excessive skin cell turnover on the scalp. Originally introduced in the , the product provides maximum-strength relief without a prescription and is suitable for both men and women. Developed by , Selsun Blue was acquired by , Inc. in 2002 for $75 million, with Abbott continuing manufacturing under contract initially. , a Chattanooga-based consumer healthcare company, integrated the brand into its portfolio of . In 2010, French pharmaceutical giant completed its $1.9 billion acquisition of Chattem. In 2024, 's consumer health division rebranded to Opella, a Certified B Corporation committed to sustainable initiatives. As of April 2025, sold a 50% controlling stake in Opella to (CD&R), with Sanofi retaining a minority stake. Today, the brand emphasizes science-backed scalp health solutions, with products distributed widely in the United States and select international markets. Selsun Blue offers a range of formulations to address varying needs, including the maximum-strength medicated version for severe , a moisturizing variant with added conditioners to prevent dryness, and 2-in-1 shampoo-conditioner options for convenience. Some products incorporate complementary ingredients like pyrithione zinc for milder daily use or for a cooling sensation that soothes the during application. While effective for its intended purposes, users should avoid contact with eyes and broken skin, and consult a doctor if symptoms persist.

History

Development and Introduction

Selsun Blue was initially developed by in the early 1950s as a selenium sulfide-based treatment targeted at conditions, including and seborrheic . The active ingredient, selenium sulfide, received FDA approval for medical use on May 17, 1951. Key clinical trials in the early 1950s established its efficacy against , the fungus implicated in , by demonstrating reduced fungal growth and symptom relief in patients with scalp disorders. A notable study in the Journal of the reported successful treatment outcomes for seborrheic dermatitis using selenium sulfide shampoo, supporting its antifungal mechanism. These findings paved the way for the product's market entry, with the first Selsun Blue formulation launched in as a prescription medicated for control. Early marketing efforts by Abbott emphasized the shampoo's prescription-strength content, promoting it as a robust solution for severe, fungus-related issues unresponsive to milder remedies.

Brand Ownership and Evolution

Selsun Blue was originally developed by and transitioned from a prescription product in 1953 to an over-the-counter medication in 1974, marking a significant shift toward broader consumer accessibility. In 2002, Abbott sold the brand to , Inc. for $75 million, including worldwide manufacturing and sales rights except in , with initial contract manufacturing handled by Abbott to ensure continuity. This acquisition allowed to revitalize the brand through renewed efforts starting in 2003, emphasizing its role as a leading medicated for everyday use. Chattem's facilitated product line enhancements, including the introduction of scented and moisturizing to appeal to diverse consumer preferences, while expanding distribution in key markets. In 2010, acquired Chattem for approximately $1.9 billion, integrating Selsun Blue into its global consumer healthcare portfolio and enabling enhanced international marketing strategies across regions like , , and . This move supported broader market penetration, with the brand achieving presence in countries such as , the , and through localized campaigns. In 2024, 's consumer health division, including Selsun Blue, rebranded to Opella as a Certified B Corporation committed to sustainable . On April 30, 2025, and closed a transaction forming a , with acquiring a 50% controlling stake in Opella. Under this joint stewardship as of November 2025, Selsun Blue has evolved with a focus on initiatives post-2020, including interactive online campaigns like the 2021 Upside Down Class Pass Series and a 2025 digital-first reveal for the 20% Extra Campaign. In 2023, appointed as its North American creative agency of record, overseeing branding for Selsun Blue alongside other products to drive modern, targeted consumer engagement. These efforts have prioritized integration and outreach to maintain relevance in a competitive personal care landscape.

Composition

Active Ingredients

Selsun Blue primarily contains selenium sulfide as its key , formulated at a 1% concentration in most over-the-counter variants to treat and seborrheic . This compound demonstrates potent antifungal properties targeted against species, the yeast associated with scalp conditions, with antifungal properties against Malassezia species, attributed to the toxicity of selenium to fungi, by disrupting fungal cellular processes. Beyond its antifungal effects, selenium sulfide functions as an antimitotic agent, slowing the proliferation and turnover of epidermal cells on the , while also reducing sebum production to minimize oiliness and subsequent scaling. Historically, earlier prescription formulations of selenium sulfide shampoos, including initial versions related to Selsun Blue, employed higher 2.5% concentrations, but regulatory developments in the led to the approval and standardization of 1% for over-the-counter use to balance efficacy with safety. Certain Selsun Blue variants incorporate adjunct actives like pyrithione zinc in place of or alongside for enhanced action in specific formulations. In select international markets, as of 2024, advanced formulations incorporate alongside for dual action.

Inactive Ingredients

Selsun Blue shampoos contain a variety of inactive ingredients that serve as the formulation base, aiding in cleansing, stability, texture, and preservation without contributing to the product's therapeutic effects. functions as the primary solvent, comprising the bulk of the formulation to dissolve and carry other components. such as and ammonium laureth sulfate provide cleansing action by reducing and enabling lathering, while acts as a mild, foam-boosting agent to enhance during application. Additional inactives include viscosity controllers like and , which thicken the product for better spreadability and handling, and emulsifiers such as or MEA that maintain homogeneity and improve foam stability. Fragrance components are incorporated to mask odors and provide a pleasant scent, often neutral or lightly floral in standard formulations. Preservatives like inhibit microbial growth, while chelating agents such as disodium EDTA help stabilize the formulation by binding metal ions, ensuring and during use. These ingredients collectively support pH balance for scalp compatibility and overall product integrity, with and often used as buffering agents. Formulations vary across regions to comply with local regulations, including paraben-free options in many current products to address consumer and concerns. The following table summarizes common inactive ingredients and their primary roles based on standard medicated variants:
IngredientRole
WaterSolvent
Surfactant/cleansing
Ammonium laureth sulfateSurfactant/cleansing
/surfactant
Magnesium aluminum silicateViscosity controlling/thickener
Emulsifying/foam booster
FragrancePerfuming
Buffering/ adjustment
These supportive elements interact minimally with the active selenium sulfide, primarily facilitating its even distribution on the .

Formulations

Shampoo Variants

Selsun Blue offers a range of formulations primarily containing 1% selenium sulfide as the for over-the-counter dandruff control, with variations tailored to specific hair and needs. The standard medicated antidandruff shampoo provides maximum strength relief from symptoms, including itching and flaking, through its properties that target dead skin cell removal. It is suitable for regular use and available in an 11 fl. oz. (325 ml) bottle. A moisturizing variant of the 1% selenium sulfide shampoo incorporates hydrating elements like to address dandruff while preventing dryness in damaged or dry hair types. This version maintains the core antidandruff efficacy in the same bottle size. The 2-in-1 antidandruff shampoo and conditioner combines 1% with conditioning agents such as vitamin B5 to cleanse, treat , and strengthen hair in a single application. It targets normal hair prone to flaking and is also packaged in 11 fl. oz. bottles. For severe or seborrheic dermatitis, a prescription-strength 2.5% variant, such as Selsun Rx, is available in the and recommended for application twice weekly for two weeks, followed by once-weekly maintenance to control symptoms. Availability of the 2.5% strength varies by region; for example, it is over-the-counter in . This higher concentration formulation requires medical supervision due to potential increased irritation. Specialized options include the Itchy Dry Scalp antidandruff shampoo, formulated with 1% pyrithione zinc for daily gentle cleansing and relief of itchiness and dryness associated with mild . The Naturals Itchy Dry Scalp variant uses 3% combined with herbal Botanicals, vitamin B5, and to soothe sensitive, dry scalps while exfoliating flakes. Variants are distinguished by packaging, including 11 fl. oz. sizes as standard in the market, with some international options in 200 ml and 400 ml bottles; color differences in bottle caps or labels aid identification, such as blue for medicated lines.

Non-Shampoo Products

Selsun Blue offers topical formulations beyond its shampoo line, primarily through the Balanced Treatment product, designed for direct skin application to address fungal infections. This product contains selenium sulfide as the active ingredient and is indicated for treating , a common fungal condition that causes skin discoloration, as well as seborrhea on non-scalp areas. The 2.5% strength variant is specifically recommended for body use, where it is applied to affected areas, lathered with water, left on for 10 minutes, and then rinsed off, typically repeated daily for up to seven days. Available in or forms, these non-shampoo products facilitate easier application on body surfaces compared to shampoos, allowing for targeted treatment of dermatological issues without requiring cleansing. The variant, in particular, provides a convenient, spreadable texture for non-scalp regions. Like the shampoo formulations, the active ingredient selenium sulfide works by inhibiting fungal growth and reducing skin cell turnover. The Balanced Treatment line has faced discontinuation in some markets, with generic equivalents now more commonly available; in the , the 2.5% strength requires a prescription, while OTC access varies in international markets. These adaptations emphasize skin-friendly delivery for broader .

Uses and Efficacy

Treatment of Seborrheic Dermatitis and Dandruff

Selsun Blue, containing selenium sulfide as its , is primarily indicated for the treatment of and seborrheic of the , conditions often linked to overgrowth of the Malassezia. The properties of selenium sulfide target this , reducing inflammation, flaking, and itching. In one sentence, its mechanism involves inhibiting fungal growth and cytostatic effects on hyperproliferative skin cells. Clinical studies demonstrate the efficacy of selenium sulfide shampoos in alleviating symptoms of and seborrheic . A prospective single-center study of 30 participants using a 2.5% applied twice weekly for four weeks resulted in a 78.3% reduction in flaking scores and 73.3% of users reporting no itching by week four, indicating substantial symptom relief within 2-4 weeks. Earlier comparative trials from the 1960s to 2000s similarly showed significant improvements in scaling and pruritus, with response rates often exceeding 70% in moderate to severe cases. Recommended usage involves applying the to wet hair, massaging into the to create a lather, leaving it on for 2-3 minutes, and then rinsing thoroughly. For initial treatment of or seborrheic , it should be used twice weekly for two weeks, followed by once weekly or as needed for maintenance to control symptoms. In comparisons with alternatives, selenium sulfide shampoo shows superiority over zinc pyrithione-based products for severe seborrheic , attributed to its stronger action against species. For long-term management, prophylactic once-weekly use helps prevent recurrence.

Other Dermatological Applications

Selsun Blue, containing selenium sulfide as its active ingredient, is applied off-label for the treatment of (also known as ), a superficial caused by species that leads to discolored patches on the skin. The recommended method involves full-body lathering with a selenium sulfide (typically 2.5% prescription strength), allowing it to remain on the skin for 10 minutes daily for 7 consecutive days, followed by thorough rinsing; this approach has demonstrated superior efficacy compared to in clinical trials. Beyond scalp conditions, selenium sulfide in Selsun Blue is utilized for body and , particularly when fungal overgrowth contributes to symptoms. For plaques on the body, topical application helps reduce scaling and inflammation by exerting cytostatic effects on hyperproliferating . In cases of , presenting as acne-like pustules, the antifungal properties of selenium sulfide effectively target the , with guidelines recommending shampoo application to affected areas twice weekly after initial daily use. In , Selsun Blue sees occasional for pet skin conditions such as yeast dermatitis in dogs, where it may help alleviate flaking and from Malassezia overgrowth, though it is not officially endorsed and can cause in animals with sensitive or raw skin. Post-2020 research highlights emerging adjunctive roles for selenium sulfide in managing and eczema, particularly when fungal elements are involved; for instance, it serves as a supportive in fungal () by reducing yeast proliferation alongside standard treatments. In eczema, preliminary applications suggest benefits in seborrheic variants through its and actions, though further studies are needed to confirm efficacy.

Side Effects and Safety

Common Adverse Reactions

Selsun Blue, containing selenium sulfide as its , commonly causes mild dermatologic reactions such as irritation, dryness, or excessive oiliness. These effects are among the more frequently reported adverse reactions and typically occur in a subset of users, often resolving upon reducing the frequency of application or with thorough rinsing. A notable is temporary hair discoloration, manifesting as an orange or reddish tint, particularly in individuals with blonde, gray, or chemically treated (, tinted, or permed) . This occurs due to the chemical interaction between selenium sulfide and pigments, and it can usually be minimized by ensuring the product is thoroughly rinsed from the . Symptoms of , including scalp redness, itching, or burning, have been documented in post-marketing reports since the product's introduction as a prescription in the . These reactions are generally uncommon but may necessitate discontinuation of use if they persist. Users often report dissatisfaction with the product's strong medicinal , reminiscent of or , which can linger on the hair and . This sensory has been addressed in more recent formulations through the addition of masking scents like mint or notes.

Precautions and Contraindications

Selsun Blue, containing selenium sulfide as its , is contraindicated in individuals with known to selenium sulfide or any other components of the formulation. It should also be avoided on blistered, raw, oozing, broken, or acutely inflamed skin, as application may exacerbate irritation or lead to systemic absorption risks. Selenium sulfide is classified by the National Toxicology Program as reasonably anticipated to be a human carcinogen based on sufficient evidence from animal studies showing liver and lung tumors following oral exposure. However, no carcinogenic effects have been demonstrated with topical application, and the risk is considered low for intended use as a shampoo. Regarding pregnancy, selenium sulfide is classified as FDA Pregnancy Category C, indicating that animal reproduction studies have not been conducted and potential risks to the fetus cannot be ruled out; use is generally not recommended under ordinary circumstances, and consultation with a healthcare provider is advised if benefits outweigh risks. For breastfeeding individuals, it is unknown whether selenium sulfide is excreted in human milk, warranting caution and physician consultation to assess potential effects on nursing infants. Special precautions apply to pediatric use, particularly for children under 2 years of age, where and have not been established, and application should only occur under medical supervision or be avoided altogether. Similarly, it is not recommended for use on open wounds or severely compromised skin barriers in any age group, with dilution potentially considered only under professional guidance to mitigate irritation risks.

Availability and Regulation

Market Distribution

Selsun Blue is widely available as an over-the-counter (OTC) product through and pharmacies, including , Target, and . In , it is similarly accessible OTC at retailers such as , , and Jean Coutu. The product has been distributed in the US since its launch as a prescription in 1953, transitioning to OTC status in 1974. Internationally, Selsun Blue is exported and sold in countries including , , , and , often through local pharmacies, grocery stores, and platforms. In , it was manufactured locally and available in 200ml bottles at pharmacies and grocery outlets until the 2.5% variant (Selsun Gold) was cancelled by the effective June 26, 2025. In , variants are offered through online marketplaces like Amazon India and , as well as pharmacy chains. Online sales of Selsun Blue have expanded significantly since the , with broad availability on platforms like Amazon and the official brand website. Subscription models, such as 's Subscribe & Save, allow for recurring purchases with discounts, enhancing consumer accessibility. Pricing for Selsun Blue typically ranges from $5 to $10 USD per 11 fl. oz. bottle in the , varying by retailer, variant, and promotions; for example, it retails for $7.92 at and $7.99 at Target. In , prices are comparable, around CAD $14.97 at . Regional variations occur internationally, influenced by import duties and local market conditions.

Regulatory Approvals and Restrictions

Selsun Blue, containing selenium sulfide as its active ingredient, received FDA approval in the United States on May 17, 1951, initially as a prescription product before being reclassified as an over-the-counter (OTC) drug. It falls under the FDA's OTC Monograph M032 for Drug Products for the Control of , Seborrheic , and , specifically 21 CFR § 358.710 for active ingredients used to treat and seborrheic of the , allowing concentrations of 1% selenium sulfide without requiring individual new drug applications. This monograph status ensures its availability as a safe and effective OTC treatment when used as directed, with ongoing FDA oversight through post-market surveillance. In the , selenium sulfide (listed as selenium disulphide) is regulated under the Cosmetics Regulation (EC) No 1223/2009 as a cosmetic rather than a medicinal product for anti-dandruff shampoos. It is permitted in rinse-off hair products at a maximum concentration of 1% (expressed as ), subject to specific labeling requirements warning of potential skin irritation and the need to avoid . However, classification can vary by ; products making therapeutic claims for conditions like seborrheic may be treated as medicinal products under Directive 2001/83/EC, requiring marketing authorization instead of cosmetic notification. No is required for cosmetics, but compliance with good manufacturing practices and safety assessments is mandatory since the regulation's implementation in 2013. Restrictions on Selsun Blue and selenium sulfide-containing products exist in several regions due to concerns over , including potential carcinogenicity and environmental impact from . In Japan, selenium sulfide is banned in over toxicity risks. Similar limitations apply in the post-Brexit, where high-strength formulations were discontinued in 2022 following MHRA review of safety data. In , the 2.5% variant was classified as a Schedule 3 (pharmacist-only) medicine for certain uses and available over-the-counter as a therapeutic good registered with the (TGA) until its cancellation effective June 26, 2025, with no outright ban prior. No verified evidence supports a pre-2015 ban in ; instead, selenium sulfide remains in use under cosmetics regulations, with market growth noted through 2025. As of 2025, global regulatory bodies continue to affirm the safety of approved selenium sulfide concentrations based on established toxicological profiles, with no major post-pandemic overhauls specific to Selsun Blue. Environmental considerations have prompted some manufacturers to pursue eco-labeling for packaging, aligning with broader sustainability standards like those from the EPA, though no mandatory requirements target this product directly.

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