Sports in Pennsylvania includes numerous professional sporting teams, events, and venues located in the U.S. state of Pennsylvania.

Pennsylvania is home to eight teams from the five major American professional sports leagues.

Football is the most popular sport in Pennsylvania, especially in the Lehigh Valley, Northeastern Pennsylvania, Central Pennsylvania, and Western Pennsylvania. Western Pennsylvania in particular was home to some of the earliest moments in football history, and the earliest professional clubs played in the Western Pennsylvania Professional Football Circuit. Pudge Heffelfinger was the first known professional football player, while John Brallier was the first openly professional player. The Allegheny Athletic Association fielded the first entirely openly professional team in 1896. In 1902, three Pennsylvania teams founded the National Football League (which has no ties to today's NFL), the first attempt at a national professional football league. Jim Thorpe, a multi-sport athlete who played in the NFL and won Olympic gold medals in the pentathlon and decathlon, attended Carlisle Indian Industrial School in Carlisle, Pennsylvania. Jim Thorpe, Pennsylvania is named after him.

Today, football is popular on all levels, from high school, college, and professionally. The high school games get regular attention in the local newspapers and games regularly draw over 10,000 fans. Pennsylvania produces several college and professional players every year, and Western Pennsylvania is noted for being the home of numerous quarterbacks, including Dan Marino, Joe Montana, and Johnny Unitas.

Professionally, the Pittsburgh Steelers and Philadelphia Eagles of the NFL are also hugely popular. Both franchises entered the NFL in 1933, and the two franchises briefly merged during World War II. Both teams have fan bases across the entire state, and in the case of the Steelers, are one of the most popular sports teams in the United States, if not the world. (This is likely due to that team's dominance in the NFL during the 1970s.) While the Eagles are not quite as popular as the Steelers outside Pennsylvania, they still maintain a passionate fan base in the Philadelphia area and across the United States as they are one of the more popular teams in the NFL. Often one of the rowdiest in the NFL, the Eagles fanbase is known for their passion and dedication. In fact, the Eagles' old home field, Veterans Stadium, was the first sports stadium in the United States to have a jail cell as a result of the rowdiness of the fans, but was removed only a couple years later after incidents settled down. Both fanbases though are considered to be among the best traveled fanbases in the NFL. During games in which the teams are on the road, Steelers fans and Eagles fans alike migrate to the opposing team's stadium and always have a strong presence, and in some cases, their numbers have made opposing teams feel as if they are not in their home stadium—a testament to the die-hard fanbases of professional football in Pennsylvania.

Pennsylvania has also been home to two defunct NFL franchises, both of which played in the 1920s. The Pottsville Maroons played in Pottsville, Pennsylvania; the franchise is notable for its part in the 1925 NFL Championship controversy. Frankford (a neighborhood in Philadelphia) also briefly had its own team in the 1920s, known as the Frankford Yellow Jackets. The team won the 1926 NFL Championship, but disbanded during the Great Depression. A third NFL franchise, the Dallas Texans, was briefly headquartered in Hershey, Pennsylvania during the 1952 season. Pennsylvania also had teams in four national leagues that competed with the NFL: the 1920s AFL, the 1930s AFL, the World Football League, and the USFL.

Philadelphia was also home to an Arena Football League team, the Philadelphia Soul who played in the league from 2004 to 2019. Pittsburgh was also the home to one of the founding Arena Football League franchises, the Pittsburgh Gladiators. After four seasons in Pittsburgh, the team moved to Tampa, Florida, in 1991 and became the Tampa Bay Storm. Pittsburgh got another AFL team in 2011, the Pittsburgh Power, which folded in 2014. The Wilkes-Barre/Scranton Pioneers played in the AFL's minor league af2 until that league disbanded in 2009.

In addition to NFL and arena football teams, Pennsylvania is also home to minor professional teams from numerous other leagues. Men's teams include the Chambersburg Cardinals and the Pittsburgh Colts. There are also several women's football teams, including the Keystone Assault, Pittsburgh Passion, and Philadelphia Firebirds.