In mathematics, a spline is a function defined piecewise by polynomials. In interpolating problems, spline interpolation is often preferred to polynomial interpolation because it yields similar results, even when using low degree polynomials, while avoiding Runge's phenomenon for higher degrees.

In the computer science subfields of computer-aided design and computer graphics, the term spline more frequently refers to a piecewise polynomial (parametric) curve. Splines are popular curves in these subfields because of the simplicity of their construction, their ease and accuracy of evaluation, and their capacity to approximate complex shapes through curve fitting and interactive curve design.

The term spline comes from the flexible spline devices used by shipbuilders and draftsmen to draw smooth shapes.

The term "spline" is used to refer to a wide class of functions that are used in applications requiring data interpolation and/or smoothing. The data may be either one-dimensional or multi-dimensional. Spline functions for interpolation are normally determined as the minimizers of suitable measures of roughness (for example integral squared curvature) subject to the interpolation constraints. Smoothing splines may be viewed as generalizations of interpolation splines where the functions are determined to minimize a weighted combination of the average squared approximation error over observed data and the roughness measure. For a number of meaningful definitions of the roughness measure, the spline functions are found to be finite dimensional in nature, which is the primary reason for their utility in computations and representation. For the rest of this section, we focus entirely on one-dimensional, polynomial splines and use the term "spline" in this restricted sense.

According to Gerald Farin, B-splines were explored as early as the nineteenth century by Nikolai Lobachevsky at Kazan University in Russia.

Before computers were used, numerical calculations were done by hand. Although piecewise-defined functions like the sign function or step function were used, polynomials were generally preferred because they were easier to work with. Through the advent of computers, splines have gained importance. They were first used as a replacement for polynomials in interpolation, then as a tool to construct smooth and flexible shapes in computer graphics.

It is commonly accepted that the first mathematical reference to splines is the 1946 paper by Schoenberg, which is probably the first place that the word "spline" is used in connection with smooth, piecewise polynomial approximation. However, the ideas have their roots in the aircraft and shipbuilding industries. In the foreword to (Bartels et al., 1987), Robin Forrest describes "lofting", a technique used in the British aircraft industry during World War II to construct templates for airplanes by passing thin wooden strips (called "splines") through points laid out on the floor of a large design loft, a technique borrowed from ship-hull design. For years the practice of ship design had employed models to design in the small. The successful design was then plotted on graph paper and the key points of the plot were re-plotted on larger graph paper to full size. The thin wooden strips provided an interpolation of the key points into smooth curves. The strips would be held in place at discrete points (called "ducks" by Forrest; Schoenberg used "dogs" or "rats") and between these points would assume shapes of minimum strain energy. According to Forrest, one possible impetus for a mathematical model for this process was the potential loss of the critical design components for an entire aircraft should the loft be hit by an enemy bomb. This gave rise to "conic lofting", which used conic sections to model the position of the curve between the ducks. Conic lofting was replaced by what we would call splines in the early 1960s based on work by J. C. Ferguson at Boeing and (somewhat later) by M.A. Sabin at British Aircraft Corporation.

The word "spline" was originally an East Anglian dialect word.