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ADAM22
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| ADAM22 | |||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||
| Aliases | ADAM22, ADAM 22, MDC2, ADAM metallopeptidase domain 22, EIEE61, DEE61 | ||||||||||||||||||||||||||||||
| External IDs | OMIM: 603709; MGI: 1340046; HomoloGene: 37898; GeneCards: ADAM22; OMA:ADAM22 - orthologs | ||||||||||||||||||||||||||||||
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Disintegrin and metalloproteinase domain-containing protein 22, also known as ADAM22, is an enzyme that in humans is encoded by the ADAM22 gene.[5][6][7]
Function
[edit]ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript variants.[7]
Interactions
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000008277 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040537 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sagane K, Ohya Y, Hasegawa Y, Tanaka I (August 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.
- ^ Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP (September 1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene. 237 (1): 61–70. doi:10.1016/S0378-1119(99)00302-9. PMID 10524237.
- ^ a b "Entrez Gene: ADAM22 ADAM metallopeptidase domain 22".
- ^ Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (September 2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science. 313 (5794): 1792–5. Bibcode:2006Sci...313.1792F. doi:10.1126/science.1129947. PMID 16990550. S2CID 33024022.
Further reading
[edit]- Harada T, Nishie A, Torigoe K, Ikezaki K, Shono T, Maehara Y, Kuwano M, Wada M (October 2000). "The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas". Japanese Journal of Cancer Research. 91 (10): 1001–6. doi:10.1111/j.1349-7006.2000.tb00877.x. PMC 5926265. PMID 11050470.
- Zhu Pc, Sun Y, Xu R, Sang Y, Zhao J, Liu G, Cai L, Li C, Zhao S (February 2003). "The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading". Biochemical and Biophysical Research Communications. 301 (4): 991–9. Bibcode:2003BBRC..301..991Z. doi:10.1016/S0006-291X(03)00056-1. PMID 12589811.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2) R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Sagane K, Hayakawa K, Kai J, Hirohashi T, Takahashi E, Miyamoto N, Ino M, Oki T, Yamazaki K, Nagasu T (2006). "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice". BMC Neuroscience. 6 33. doi:10.1186/1471-2202-6-33. PMC 1142324. PMID 15876356.
- Zhu P, Sang Y, Xu H, Zhao J, Xu R, Sun Y, Xu T, Wang X, Chen L, Feng H, Li C, Zhao S (June 2005). "ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3". Biochemical and Biophysical Research Communications. 331 (4): 938–46. Bibcode:2005BBRC..331..938Z. doi:10.1016/j.bbrc.2005.03.229. PMID 15882968.
- D'Abaco GM, Ng K, Paradiso L, Godde NJ, Kaye A, Novak U (January 2006). "ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain". Neurosurgery. 58 (1): 179–86, discussion 179–86. doi:10.1227/01.NEU.0000192363.84287.8B. PMID 16385342. S2CID 24601244.
- Gödde NJ, D'Abaco GM, Paradiso L, Novak U (August 2006). "Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members". Journal of Cell Science. 119 (Pt 16): 3296–305. doi:10.1242/jcs.03065. PMID 16868027.
- Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (September 2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science. 313 (5794): 1792–5. Bibcode:2006Sci...313.1792F. doi:10.1126/science.1129947. PMID 16990550. S2CID 33024022.
- Chabrol E, Gourfinkel-An I, Scheffer IE, Picard F, Couarch P, Berkovic SF, McMahon JM, Bajaj N, Mota-Vieira L, Mota R, Trouillard O, Depienne C, Baulac M, LeGuern E, Baulac S (August 2007). "Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy" (PDF). Epilepsy Research. 76 (1): 41–8. doi:10.1016/j.eplepsyres.2007.06.014. PMID 17681454. S2CID 28172409.[permanent dead link]
- Gödde NJ, D'Abaco GM, Paradiso L, Novak U (November 2007). "Differential coding potential of ADAM22 mRNAs". Gene. 403 (1–2): 80–8. doi:10.1016/j.gene.2007.07.033. PMID 17884303.
External links
[edit]- The MEROPS online database for peptidases and their inhibitors: M12.978
- Human ADAM22 genome location and ADAM22 gene details page in the UCSC Genome Browser.
ADAM22
View on Grokipediafrom Grokipedia
Adam John Grandmaison (born November 24, 1983), known professionally as Adam22, is an American podcaster, YouTuber, and media entrepreneur who founded the No Jumper platform in 2015, specializing in interviews and content centered on hip-hop artists, underground rap scenes, and internet culture.[1][2]
Originally gaining prominence through his BMX-focused website The Come Up, which he launched in 2006 and grew into the largest of its kind, Grandmaison transitioned to hip-hop coverage, establishing No Jumper as a key tastemaker for emerging talent in the genre.[3][1] The No Jumper YouTube channel has amassed nearly 5 million subscribers, earning YouTube's Gold Play Button for surpassing 1 million subscribers in 2017, and generates significant revenue through podcasts, merchandise, and related ventures.[4][5]
Grandmaison's career has been marked by entrepreneurial success, including past involvement in poker and a reported net worth of approximately $4-5 million, derived primarily from online content creation.[6][7] However, he has faced multiple controversies, including 2018 allegations of sexual assault and coercion from former associates and guests, which he has denied, resulting in the termination of a recording deal with Atlantic Records.[8][9][10] In 2023, Adam22 attracted intense public backlash for promoting and distributing an adult video featuring his wife, Lena the Plug, engaging in sexual acts with another male performer, Jason Luv, amid debates over relationship dynamics and content boundaries.[11][12] Additional incidents, such as interviewing individuals linked to high-profile crimes and workplace altercations, have further shaped perceptions of his unfiltered approach to media.[13][14]