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Fluotracen
Fluotracen
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Chemical compound
Pharmaceutical compound
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| Routes of administration | Oral |
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| Formula | C21H24F3N |
| Molar mass | 347.425 g·mol−1 |
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Fluotracen (SKF-28,175) is a tricyclic drug which has both antidepressant and antipsychotic activity.[1][2][3] This profile of effects is similar to that of related agents like amoxapine, loxapine, and trimipramine which may also be used in the treatment of both depression and psychosis.[1] It was believed that such duality would be advantageous in the treatment of schizophrenia, as depression is often comorbid with the disorder and usual antipsychotics often worsen such symptoms.[1] In any case, however, fluotracen was never marketed.[3]
- ^ a b c Annual Reports in Medicinal Chemistry: v. 14. Academic Press Inc.,U.S. 1979. ISBN 0-12-040514-8.
- ^ Fowler PJ, Zirkle CL, Macko E, et al. (1977). "Fluotracen: a tricyclic compound with the combined properties of antidepressants and antipsychotics in animals". Arzneimittel-Forschung. 27 (8): 1589–95. PMID 410422.
- ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
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| Antidepressants (Tricyclic antidepressants (TCAs)) |
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| Antihistamines |
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| Antipsychotics |
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