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Savlon
INN: Cetrimide and chlorhexidine gluconate
Combination of
CetrimideAntiseptic
Chlorhexidine gluconateAntiseptic
Clinical data
AHFS/Drugs.comhttps://www.drugs.com/uk/savlon-antiseptic-cream-leaflet.html
Legal status
Legal status
Identifiers
CAS Number

Savlon is a brand of antibacterial personal care products with the active ingredients of cetrimide and chlorhexidine gluconate.[1] Commonly sold as a cream, the product range also includes antiseptic sprays, sticking plasters and other antiseptic products.

History

[edit]

The product name is derived from the original Imperial Chemical Industries (ICI) manufacturing site name of the Avlon Works at Avonmouth near Bristol, UK on the Severn Estuary.[citation needed]

Savlon is sold in many countries with different manufacturing and licensing agreements.

In 1992, Johnson & Johnson acquired the Savlon OTC brands from ICI.[2] Since then, Johnson & Johnson manufactures and distributes Savlon products throughout Sub-Saharan Africa. In 2015, Johnson & Johnson sold Indian rights to the Savlon and Shower To Shower brands to ITC Limited.[3]

Also in 1992, ICI sold its Bangladesh rights to Savlon to ICI Bangladesh Manufacturers Limited, now ACI Limited.[4]

In Australia, Savlon was acquired by Reckitt Benckiser after its takeover of Boots Healthcare (International) in late 2005.[citation needed]

In June 2019, STADA of Germany acquired UK rights to Savlon from GlaxoSmithKline Consumer Products for its UK subsidiary Thornton & Ross.[5]

Savlon antiseptic liquid 250 ml flask.

Formulation

[edit]

The active ingredients in Savlon products are two antiseptics, cetrimide and chlorhexidine gluconate.[1] These agents were discovered and first developed by Imperial Chemical Industries (ICI).[6]

Savlon is commonly sold as an antiseptic liquid. It is used for cleansing and prevention of infection in skin lesions, including small cuts and blisters and minor burns, and is useful in first aid kits. Other items sold in the Savlon range include hygiene soap, antiseptic cream, and healing gel. Savlon's antiseptic liquid comes in the SKU sizes of 75 ml, 125 ml, 250 ml, 500 ml, 750 ml and 2 L.

References

[edit]
Revisions and contributorsEdit on WikipediaRead on Wikipedia

Savlon

View on Grokipedia
from Grokipedia
Savlon is a of antiseptic liquids, creams, and related hygiene products sold around the world. Originally developed in the 1950s by (ICI), it features the active ingredients and gluconate, which provide effective germ protection without stinging the skin. Ownership varies by region; for example, it is manufactured by in since 2015 and by Thornton & Ross in the .

History

Origins and Development

Savlon originated from research efforts by (ICI) in the during the 1940s and 1950s, when scientists identified and as effective agents. Cetrimide, a quaternary ammonium compound, was developed by ICI researchers in the 1940s for its antimicrobial properties and introduced under the brand name Cetavlon for applications such as wound cleaning. Similarly, chlorhexidine was synthesized in the late 1940s during ICI's investigations into anti-malarial compounds, revealing its broad-spectrum antibacterial activity suitable for disinfection. These discoveries laid the foundation for combining the two agents into a synergistic . The initial development of Savlon as a branded product took place at ICI's Avlon Works facility in , near , , where it was developed in the early and first launched in specifically as a surgical . The name "Savlon" derives directly from this manufacturing site. Early clinical evaluations in the demonstrated the formulation's ability to reduce bacterial load on , supporting its approval for use in preventing postoperative infections during medical procedures. By the mid-1950s, Savlon transitioned from specialized medical applications—initially as a —to broader consumer availability, launching for everyday and needs in the UK. This marked its entry into households, with advertisements promoting it for minor wounds and general cleansing. The product line soon expanded to include a cream variant in 1954, enhancing its versatility for topical application and further solidifying its role in personal care.

Ownership and Regional Acquisitions

In 1992, as (ICI) underwent significant divestitures ahead of its pharmaceutical division demerger, the rights to the Savlon brand were fragmented regionally to facilitate focused management and distribution. This process aligned with ICI's strategic shift, where over-the-counter (OTC) assets like Savlon were allocated to specialized entities for global expansion. acquired the Savlon OTC portfolio from ICI for more than 70 countries outside the European Community, encompassing regions such as , the , and ; this deal enabled enhanced marketing of Savlon antiseptics for and in these markets, with terms undisclosed. Concurrently, in , ICI transferred Savlon rights to its local through a , rebranding it as Advanced Chemical Industries (ACI) Limited and fostering localized production to meet regional demand. The following year, in 1993, ICI's pharmaceutical division was demerged to form Zeneca Group PLC, with remaining Savlon rights in integrated into this new entity, supporting continued operations amid the brand's regional splits. In India, Johnson & Johnson's Savlon rights were later sold to in 2015, allowing ITC to ramp up local and distribution as part of its FMCG expansion . Australia's Savlon rights, previously under Boots Healthcare International, were acquired by Reckitt Benckiser in late 2005 following its £1.93 billion purchase of Boots' global OTC business, which bolstered Reckitt's antiseptic portfolio in the Australasian market. In the UK and broader Europe, Zeneca's eventual merger into AstraZeneca in 1999 led to further transfers, culminating in GlaxoSmithKline (GSK) holding the rights until 2019, when STADA Arzneimittel acquired the UK Savlon portfolio—including ongoing European operations—for its subsidiary Thornton & Ross to strengthen its skin care offerings. These acquisitions enhanced Savlon's global distribution by aligning it with companies experienced in consumer health, ensuring sustained availability across diverse regions.

Products

Antiseptic Liquids and Creams

Savlon liquid is formulated as a topical solution for first-aid use, available in sizes including 75 ml, 125 ml, 250 ml, 500 ml, 750 ml, and 2 L. These sizes cater to varying needs, from portable options for to larger volumes for home storage and general . The liquid is typically diluted with to cleanse and disinfect minor injuries effectively. In first-aid scenarios, Savlon antiseptic liquid is applied to disinfect lesions and blisters, helping to prevent infection by removing dirt and germs from affected areas. Its antibacterial properties make it suitable for routine tasks beyond wounds, such as surface cleaning in the home. Savlon antiseptic cream is offered in tube formats, such as 30 g and 100 g, for convenient direct application to minor injuries. This cream form allows for targeted treatment on cuts, abrasions, and minor burns, providing a soothing barrier while cleansing the area. It is commonly used in everyday first-aid kits for quick relief from superficial wounds. The cream is packaged in lacquered aluminum tubes. These tubes are designed for easy dispensing and storage, maintaining the cream's efficacy for applications.

Soaps, Sprays, and Other Variants

Products vary by region due to licensing agreements; for example, in the UK and (under Brands), the focus is on liquids, creams, sprays, and gels, while in (e.g., under ), the range includes soaps and hand washes. In markets like , Savlon expanded its product line in the early 2000s to include bar s designed for everyday . The bar range was launched in , initially with a single variant, and has since grown to encompass multiple options tailored for hand and body washing. These include for broad germ protection, Mild for gentle cleansing suitable for sensitive skin, Fresh for a refreshing feel, Lemon Burst for invigorating scent, and Men for targeted needs. Available in various pack sizes from 35g to 125g, these s emphasize skin-friendly formulations that combat dryness while providing antibacterial benefits during routine use. In the UK, Savlon offered an antiseptic spray variant (as of 2024) for convenient, non-contact application on minor cuts and grazes. The Dry Antiseptic Spray dispenses a fine that forms a protective layer to help prevent without the need for direct touching, making it ideal for quick first-aid scenarios. This no-touch format enhances in fast-paced environments, supporting the brand's shift toward accessible wound care solutions. Further extending its offerings, Savlon produces sticking plasters and gels incorporating the brand's formula for enhanced . waterproof and fabric plasters feature pads that cushion injuries, promote , and guard against bacterial entry, with strong for active lifestyles. Complementing these, the Advanced Gel and Scar Prevention Gel apply a hydro-active layer to soothe from superficial burns or cuts, fostering faster recovery and minimizing formation. In tropical markets like , Savlon adapts its soap variants to local climates, where high demands products that maintain efficacy without compromising skin comfort. Variants such as Cool and Fresh incorporate cooling or invigorating elements to address sweat and in hot, humid conditions, ensuring broad for daily .

Formulation

Active Ingredients

Savlon's primary active ingredients are and chlorhexidine gluconate, which work together as antiseptics to combat microbial growth. These compounds target bacterial cells through distinct yet complementary mechanisms, making the formulation effective for topical applications. Cetrimide, chemically a of dodecyl, tetradecyl, and hexadecyl trimethyl bromides, functions as a quaternary compound and cationic . It disrupts bacterial cell by interacting with the bilayers, leading to leakage of intracellular contents and loss of integrity, which ultimately causes . In Savlon cream formulations, is included at a concentration of 0.5% w/w. In liquid formulations, is present at 3.0% w/v. Developed by (ICI), was first introduced as a and in under the brand name Cetavlon. Chlorhexidine gluconate, a bisbiguanide , binds to the negatively charged sites on bacterial cell walls due to its cationic nature, destabilizing the membrane and causing leakage of cytoplasmic components at low concentrations, while higher concentrations precipitate intracellular proteins. This results in broad-spectrum bactericidal activity. In Savlon liquid formulations, it is present at 0.3% w/v, while in creams, the concentration is 0.1% w/w. was discovered in the early by ICI during research into antimalarial agents and commercially introduced as a topical in 1954. The combination of and in Savlon, developed by ICI in the , leverages their synergistic effects to broaden antimicrobial efficacy against both Gram-positive and . Cetrimide's action enhances chlorhexidine's penetration and membrane disruption, resulting in improved killing of biofilms and resistant strains compared to either agent alone. This pairing maintains low toxicity to , as both compounds exhibit minimal at therapeutic concentrations, allowing safe topical use without significant absorption or adverse effects on host tissues.

Inactive Components and Product Forms

Savlon formulations incorporate various inactive components to ensure stability, texture, and safe application on the skin, while supporting the delivery of active antiseptics. Common inactive ingredients across products include preservatives such as and to prevent microbial growth, and emollients like liquid paraffin for protection. In antiseptic creams, additional inactives such as cetostearyl alcohol act as emulsifiers to create a stable oil-in-water emulsion. Purified water forms the base, with the overall formulation adjusted for a semi-solid consistency suitable for topical application on wounds or irritated skin. These components contribute to the cream's occlusive properties, forming a protective barrier without compromising the active ingredients' antibacterial role. Antiseptic liquids, in contrast, utilize a water-alcohol base for easy dilution and rinsing, incorporating solvents like to enhance and . Other inactives include as a and fragrance agents such as for odor masking. Viscosity modifiers are minimal in liquids, prioritizing flowability for household and first-aid uses. All Savlon products adhere to regulatory standards, including those outlined in the () for over-the-counter antiseptics, ensuring purity, stability, and safety in inactive component selection. Formulations are tested for compatibility, with excipients chosen to avoid interactions that could affect or .

Medical Applications

Indications and Efficacy

Savlon antiseptic products are primarily indicated for the cleansing and disinfection of minor cuts, abrasions, blisters, grazes, and bites, as well as for preventing in superficial wounds. These applications are supported by product labeling and regulatory approvals, which emphasize their role in for small wounds, minor burns, scalds, and superficial irritations such as chapped or nappy . Evidence from laboratory and in vivo studies demonstrates Savlon's efficacy in reducing bacterial contamination on skin and wounds. For instance, in vitro assessments have shown that Savlon formulations achieve a 99.9% reduction in common pathogens, including and , within 30 seconds of contact, based on standardized microbial challenge tests. Animal model studies, such as those using infected wounds in rats, further confirm Savlon's ability to inhibit bacterial growth, including antibiotic-resistant strains like , comparable to or exceeding in wound healing outcomes. Originally developed in the early by (ICI) as a , Savlon played a key role in preoperative preparation, with early trials evaluating its impact on reducing aerobic and anaerobic before surgical procedures. These investigations, including volunteer and patient-based experiments, established its persistent antibacterial activity, making it a standard for surgical antisepsis at the time. Compared to iodine-based antiseptics, Savlon offers advantages in skin tolerability, with randomized controlled trials reporting lower rates of and allergic reactions due to the non-staining, less oxidative nature of and . Meta-analyses of preoperative antisepsis studies highlight formulations like Savlon as superior in balancing efficacy with reduced skin adverse events relative to .

Safety Profile and Side Effects

Savlon products, primarily topical antiseptics containing gluconate and , exhibit a generally favorable safety profile with low risk of systemic due to minimal absorption when used as directed. indicate that these formulations are well-tolerated for external use on intact or minorly broken , with studies showing high LD50 values for both active ingredients— gluconate exceeding 5,000 mg/kg orally in rats and around 3,900 mg/kg orally in rats—demonstrating limited potential for severe adverse effects from topical application. This low absorption profile supports their suitability for routine first-aid use in adults and children, though specific products may have age restrictions, such as suitability for children over 3 years in certain cream formulations. Common side effects are infrequent and typically mild, including localized skin irritation, redness, or allergic reactions such as , which occur in rare cases upon application. to , a key component, can manifest as pruritus, , , or urticaria, though severe anaphylactic reactions are exceptionally uncommon and primarily associated with higher-concentration or parenteral exposures rather than standard topical Savlon use. Discontinuation of use usually resolves these symptoms promptly, and no long-term adverse effects have been widely reported from proper application. Contraindications include avoidance on deep or , eyes, mucous membranes, or sensitive areas like the genital region, as well as prohibition of internal use or to prevent potential or . Products should not be applied to the , , or , and repeated application on large areas or under occlusive dressings is discouraged to minimize any of enhanced absorption. In cases of accidental overdose, such as , symptoms are generally mild due to poor systemic , potentially including , , or gastrointestinal discomfort, but medical advice should be sought immediately. No significant interactions with other topical medications are documented, allowing safe concurrent use in most scenarios, though consultation with a healthcare provider is recommended for individuals with known allergies to quaternary ammonium compounds or .

Availability and Marketing

Global Presence

In the United Kingdom and , Savlon has been marketed by AG through its subsidiary Thornton & Ross since its acquisition from GlaxoSmithKline in 2019. The brand holds a Product Licence (PL 00240/0469) from the Medicines and Healthcare products (MHRA), classifying it as an over-the-counter medicine for use. It is widely available in pharmacies such as Boots and , as well as supermarkets including , , , , and Co-op. In , Savlon is produced and distributed by following its acquisition from in 2015, establishing it as a prominent player in the over-the-counter antiseptics market. occurs at localized facilities, including a key site in Manpura, , with additional production expansions to meet demand across states. Under the Drugs and Cosmetics Rules, 1940, Savlon's liquid antiseptics for household use are classified as drugs but exempt from certain licensing requirements via Schedule . In , Savlon serves as the flagship brand of , which acquired rights from in 1992, and remains a staple for germ in this tropical environment. The product line, including liquids, creams, and soaps, is widely distributed nationwide through pharmacies, retailers, and supermarkets. Johnson & Johnson (now ) markets Savlon across , where it is manufactured and distributed for regional needs. In and , Savlon products are available in chemists and online retailers. North American presence is limited, primarily through online imports rather than widespread retail. Regulatory classifications vary: in the , Savlon qualifies as a medical device or licensed medicine based on antiseptic claims under the Medical Devices Regulation (MDR), while in select Asian markets like , certain formulations are treated as or exempt OTC drugs.

Branding and Advertising Campaigns

Savlon's branding originated in the during the late 1950s, where early advertisements positioned the product as a gentle suitable for family use, particularly emphasizing protection for and children in settings. This positioning underscored Savlon's non-stinging formula as a safe option for minor injuries, aligning with a "gentle yet effective" narrative that resonated with parents concerned about family safety. Over the decades, this core messaging evolved to portray Savlon as a trusted essential for , from children's scrapes to adult skin irritations. In the 1980s, Savlon's advertising featured television commercials that reinforced its caring, protective role in family life, with visuals of everyday accidents treated gently at home. By the 2010s, the brand's iconic campaigns shifted toward social impact in emerging markets, particularly through hygiene education initiatives. In , ITC launched the Savlon Swasth India Mission in 2016, a program aimed at promoting handwashing behaviors among children to combat infections during disease outbreaks, reaching millions via school-based activities and innovative tools like chalk sticks that encouraged hygiene without needing extra resources. Similarly, in , ACI's Savlon supported hygiene awareness during health crises, including educational efforts tied to outbreaks, fostering community habits for germ prevention. Regional marketing strategies highlighted localized engagement to build . In , ACI orchestrated community programs like the Savlon Clean Bangladesh campaign, which used interactive games and education to promote a "germ-free" environment, serving over 10,000 participants since its inception. In , ITC leveraged celebrity endorsements for soap variants, starting with athlete in 2016 to appeal to active lifestyles, followed by actor in 2022 for the line, emphasizing gentle cleansing for daily use. These efforts extended Savlon's global presence by tailoring messages to cultural contexts, such as family-oriented protection in the UK and public health advocacy in . Post-2020, Savlon's digital campaigns pivoted to address the , focusing on through interactive initiatives. In , the Chain of Protection campaign, launched on World Hand Hygiene Day in May 2020, encouraged users to share videos of proper handwashing to form a virtual "chain" against virus spread, amplifying reach via platforms like and . Complementing this, modern branding incorporated sustainability, with ITC introducing eco-friendly packaging for Savlon in 2023, featuring 70% recycled plastic to reduce environmental impact while maintaining product efficacy. In 2024, the Savlon Swasth India Mission continued with campaigns like #HandwashLegends, partnering with hip-hop artists to make handwashing appealing to children in urban slums, and a Global Hand Hygiene Day initiative titled "Your hands aren't yours till you them," using digital ads to reinforce habitual handwashing.

References

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