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Arthrobacter
Arthrobacter
Arthrobacter
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Arthrobacter
Arthrobacter chlorophenolicus
Scientific classification Edit this classification
Domain: Bacteria
Kingdom: Bacillati
Phylum: Actinomycetota
Class: Actinomycetes
Order: Micrococcales
Family: Micrococcaceae
Genus: Arthrobacter
Conn and Dimmick 1947 (Approved Lists 1980)
Type species
Arthrobacter globiformis
corrig. (Conn 1928) Conn and Dimmick 1947 (Approved Lists 1980)
Species

See text.

Arthrobacter (from the Greek, "jointed small stick”) is a genus of bacteria that is commonly found in soil. All species in this genus are Gram-positive obligate aerobes that are rods during exponential growth and cocci in their stationary phase. Arthrobacter have a distinctive method of cell division called "snapping division" or reversion in which the outer bacterial cell wall ruptures at a joint.

Description

[edit]

Arthrobacter can be grown on mineral salts pyridone broth, where colonies have a greenish metallic center on incubated at 20 °C (68 °F). Under the microscope, Arthrobacter appear as rods when rapidly dividing, and cocci when in stationary phase. Dividing cells may also appear as chevrons ("V" shapes). Other notable characteristics are that it can use pyridone as its sole carbon source, and that its cocci are resistant to desiccation and starvation.

Use in industry

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Arthrobacter, like other bacterial genera including Brevibacterium, Microbacterium, and Corynebacterium are used for industrial production of L-glutamate. In industrial applications, Arthrobacter is often grown with low-cost sugar sources such as cane or beet molasses, starch hydrolysates from corn or cassava tubers, or tapioca. Along with sugar, ammonia and ammonium salts are added as a nitrogen source. The vitamins, minerals, and some other types of nutrients can be provided by adding corn steep liquour.

Other uses

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Various Arthrobacter species have been investigated for other commercial applications. A. crystallopoietes and A. chlorophenolicus have been shown to reduce hexavalent chromium and 4-chlorophenol levels in contaminated soil, suggesting they may be useful for bioremediation.[1][2] Similarly, Arthrobacter sp. strain R1 (American Type Culture Collection strain number 49987) has been shown to grow on a variety of aromatic compounds, including homocyclic compounds, such as hydroxybenzoates, as well as N-heterocycles, including pyridine and picoline.[3]

Arthrobacter crystallopoietes produces a pigment when grown on 2-pyridone (right) but not when grown on succinic acid (left).

Arthrobacter sp. H65-7 produces the enzyme inulase II that converts inulin into the medically relevant nutrient difructose anhydride.[4]

The enzyme Alu obtained from Arthrobacter luteus is able to cleave Alu sequences which is frequently repeated in human DNA.[5]

Species

[edit]

Arthrobacter comprises the following species:[6]

References

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[edit]
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Arthrobacter

View on Grokipedia
from Grokipedia
Arthrobacter is a of in the family and phylum Actinobacteria, first described in with Arthrobacter globiformis as the . These obligately aerobic, non-spore-forming, catalase-positive are characterized by a distinctive rod-coccus life cycle, appearing as irregular rods (0.2–1.0 by 1.0–10.0 μm) in young cultures and V- or Y-shaped arrangements that transition to spherical cocci (0.7–2.0 μm in diameter) in older cultures. They exhibit high genomic G+C content (58–68 mol%), major fatty acids such as anteiso-C15:0, and menaquinones predominantly MK-9(H2). Optimal growth occurs at 20–30°C, with many being psychrotolerant and capable of growth at 10°C but rarely at 37°C. The encompasses approximately 80 validly described , reflecting significant taxonomic revisions, including emendations in 2016 that reclassified several into novel genera like Glutamicibacter and Paenarthrobacter based on phylogenetic, chemotaxonomic, and phenotypic heterogeneity. Arthrobacter are ubiquitous in diverse environments, predominantly soils where they contribute to , but also in freshwater, marine sediments, air, extreme habitats like regions, and anthropogenic settings such as dairy products and clinical samples. In and cheese, they comprise 1–2% of the , often entering via environmental contaminants and serving as primary or secondary microflora. Arthrobacter are metabolically versatile chemoorganotrophs, capable of utilizing a broad range of carbon sources and degrading recalcitrant compounds, including xenobiotics like pesticides (e.g., by A. aurescens), hydrocarbons, chlorophenols, and . This biodegradative prowess positions them as key players in environmental and . In , certain strains produce valuable pigments such as C50- (e.g., decaprenoxanthin) and cold-active enzymes like β-galactosidases, which enhance , flavor development, and in processing. While generally non-pathogenic, some species like A. cumminsii have been implicated in opportunistic human infections, particularly in immunocompromised individuals.

Taxonomy and History

Discovery and Naming

The genus Arthrobacter traces its origins to observations made by H.J. Conn in 1928, who identified a distinctive group of bacteria in soil samples during studies of yellow-pigmented isolates from productive agricultural lands. These organisms were noted for their abundance in fertile soils but apparent absence in less productive ones, exhibiting a unique morphological transition from Gram-negative rods in young cultures to Gram-positive cocci in older ones, which Conn described as a rod-coccus cycle. This initial characterization highlighted their prevalence in soil environments but did not yet assign a formal taxonomic name. In 1947, Conn and Isabel Dimmick formally proposed the genus Arthrobacter to accommodate these soil bacteria, which displayed morphological similarities to Mycobacterium and Corynebacterium species, including irregular, often V-shaped rods. The name derives from the Greek words arthron (joint) and bakterion (small rod), reflecting the "jointed" appearance of the rod-like cells that frequently formed angled or bent configurations during growth. They designated Arthrobacter globiformis (originally described by Conn in 1928 as Bacterium globiforme) as the type species, establishing the genus based on cultural, morphological, and physiological traits such as aerobic growth and a pronounced rod-coccus life cycle. Early taxonomic efforts surrounding Arthrobacter were marked by confusion with other coryneform bacteria due to overlapping irregular rod shapes and Gram variability, leading to its initial placement within the family Corynebacteriaceae alongside genera like and . This grouping was based on superficial morphological resemblances rather than deeper chemotaxonomic or phylogenetic analyses, prompting ongoing debates about its distinctiveness from these relatives. Subsequent refinements, including and menaquinone studies, supported separation but highlighted the genus's heterogeneity. The genus name Arthrobacter Conn and Dimmick 1947 was officially validated and approved by the International Committee on Systematic Bacteriology in 1980 through inclusion in the Approved Lists of Bacterial Names, with A. globiformis confirmed as the type species and the description updated to emphasize the rod-coccus cycle per earlier emendations by R.M. Keddie. This validation provided nomenclatural stability amid prior uncertainties in coryneform classifications.

Phylogenetic Classification

Arthrobacter is classified within the domain Bacteria, phylum Actinomycetota, class Actinomycetia, order Micrococcales, and family Micrococcaceae. This placement reflects its membership in the high-G+C-content Gram-positive bacteria, with genomic DNA typically exhibiting a G+C content of 60-70 mol%, a hallmark of the phylum Actinomycetota. The genus underwent significant taxonomic revision in 2016 through an emendation that redefined Arthrobacter sensu stricto based on integrated phylogenetic, chemotaxonomic, and genomic data. This emendation led to the reclassification of 33 species into five novel genera: Glutamicibacter (9 species, e.g., G. protophormiae and G. creatinolyticus), Paeniglutamicibacter (6 species, e.g., P. nicotianae and P. psychrolerans), Pseudoglutamicibacter (2 species, e.g., P. cumminsii and P. alaniniphilus), Paenarthrobacter (6 species, e.g., Pa. aurescens), and Pseudarthrobacter (10 species, e.g., Ps. phenanthrenivorans), primarily due to differences in peptidoglycan structure, menaquinone profiles, and 16S rRNA gene sequence divergences exceeding 3%. These reclassifications addressed longstanding heterogeneity within the genus, ensuring that retained species share core traits like the A3α peptidoglycan type with lysine as the diagnostic cell-wall diamino acid (interpeptide bridge variations including L-Lys-L-Ala) and MK-9(H₂) as the predominant menaquinone. Subsequent taxonomic refinements have employed multi-locus sequence typing (MLST) and whole-genome sequencing to further resolve phylogenetic heterogeneity, particularly among environmental isolates with ambiguous 16S rRNA similarities. As of 2025, 75 species remain validly assigned to Arthrobacter sensu stricto, reflecting ongoing discoveries and genomic validations that maintain monophyly within the genus. Phylogenetic analyses, including neighbor-joining trees constructed from 16S rRNA (≈1,500 bp) and recA gene sequences, consistently position Arthrobacter as a distinct clade within Micrococcaceae, closely related to genera such as Micrococcus (sequence similarities 94-97%) and Kocuria (92-95%), underscoring shared evolutionary origins in soil and aquatic niches.

Morphology and Physiology

Cell Structure and Division

Arthrobacter species possess a Gram-positive featuring a thick layer, typically 20-30 nm in thickness, which contributes to their structural integrity. However, Gram staining results can vary with cell age: young rod forms often appear Gram-negative due to easier decolorization, while cocci exhibit greater resistance to decolorization and consistently stain Gram-positive. In the phase, Arthrobacter cells adopt a rod-shaped () morphology, with dimensions ranging from 0.2-1.3 μm in width and 1-10 μm in length. As cultures enter the stationary phase under nutrient limitation, rods undergo to spherical cocci, measuring 0.7-2 μm in , through septation and wall remodeling. This rod-to-coccus cycle is characteristic of the and reflects adaptations to changing environmental conditions during batch culture. Cell division in Arthrobacter occurs via binary fission with a unique "snapping" mechanism: the inner cell wall layer forms a , but the outer layer remains intact post-fission, creating tension that leads to its localized rupture at the division site. This rupture causes the daughter cells to separate abruptly, often forming V-, Y-, or chevron-shaped configurations. The rod-to-coccus transition occurs in stationary phase through septation, wall remodeling, and fragmentation, aiding persistence under nutrient limitation and stress. Microscopically, dividing cells frequently display V-, Y-, or chevron-shaped configurations due to this postfission bending. On solid media, Arthrobacter forms small (1-2 mm), convex, smooth colonies that are typically non-mucoid and may appear yellow-pigmented owing to the production of such as bacterioruberin.

Metabolic Capabilities

Arthrobacter species are obligate aerobes that rely on oxygen for respiration, employing a cytochrome-based to facilitate terminal . They exhibit strictly respiratory without fermentation capabilities, classifying them as chemoorganotrophs that derive energy from the oxidation of organic compounds. This aerobic lifestyle supports their survival in oxygen-rich environments, with the rod-coccus morphological transition potentially aiding metabolic adjustments during growth phases. These demonstrate nutritional versatility, utilizing a broad array of carbon sources such as sugars (e.g., glucose and ), , organic acids, and aromatic compounds (e.g., pyridine derivatives). They can grow on minimal media supplemented with inorganic nitrogen sources like , requiring no vitamins except in most cases. Optimal growth occurs at temperatures of 25–30°C and 7–8, enabling efficient nutrient assimilation under neutral to slightly alkaline conditions. Key enzymatic activities include catalase positivity, which helps manage , and variable oxidase activity across strains, with most being oxidase-negative but some and marine isolates testing positive. Arthrobacter produces specialized enzymes such as inulase II, which hydrolyzes β-2,1-linked fructans like from the nonreducing end, and choline oxidase, a bifunctional that converts choline to betaine via betaine aldehyde. These enzymes underpin their ability to process complex and osmoprotectants. Additionally, Arthrobacter exhibits high tolerance to and salts through mechanisms like efflux pumps (e.g., for , , and ) and production, which chelates metals to mitigate .

Ecology and Distribution

Natural Habitats

Arthrobacter species are predominantly soil-dwelling , commonly inhabiting arable, , and subsurface s across diverse global regions. These environments support their growth due to the nutrient-rich and fluctuating conditions typical of terrestrial ecosystems. In the upper layers of these soils, Arthrobacter populations can reach abundances of 10^6 to 10^8 cells per gram, reflecting their role as one of the most prevalent bacterial genera in soil microbiomes. Arthrobacter bacteria are also prevalent in extreme soil environments, such as the dry valleys of , permafrost regions, and arid deserts, where they contribute to microbial communities under harsh conditions. Additionally, they occur in freshwater sediments and the rhizospheres of plants, including those in agricultural settings, where they interact with root exudates. In food-related habitats, Arthrobacter species appear as contaminants in and products, often serving as secondary microflora on cheese surfaces during ripening. They are also detected in , , and processed foods, persisting from environmental sources due to their resilience. Arthrobacter strains are frequently isolated from polluted sites, including industrial soils contaminated with hydrocarbons, pesticides, and , where they form part of the adaptive microbial consortia. Globally, Arthrobacter exhibits a ubiquitous distribution, particularly in temperate and regions, though it is less common in marine environments compared to terrestrial ones.

Environmental Adaptations

Arthrobacter species exhibit remarkable resistance to and through a biphasic life cycle involving rod-to-coccus morphological transition, where the spherical coccus form serves as a dormant, resistant state that enhances under limitation and stress. This transition is accompanied by the accumulation of compatible solutes such as and , which act as osmoprotectants to maintain cellular integrity and prevent protein denaturation during dehydration. biosynthesis genes, including those encoding trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase, enable rapid response to osmotic shifts, while uptake transporters like facilitate betaine and acquisition for additional protection. Universal stress proteins further bolster tolerance by modulating metabolic slowdown and . Psychrotolerant Arthrobacter strains, particularly those isolated from high-altitude environments like the , demonstrate adaptations to cold stress through the production of proteins and cold-shock proteins that stabilize cellular structures at low temperatures. These proteins, including multiple copies of cspA homologs, facilitate ribosomal function and stabilization during sudden temperature drops, while genomic analyses reveal reduced numbers of fabG genes encoding 3-oxoacyl-[acyl-carrier-protein] reductases, suggesting optimized profiles for enhanced in subzero conditions. Such traits allow growth at temperatures as low as -1°C, contributing to their prevalence in and glacial soils. Tolerance to environmental pollutants in Arthrobacter is mediated by and plasmid-encoded degradation systems, enabling survival in contaminated sites. The chrA gene on megaplasmids encodes a chromate efflux pump that expels toxic Cr(VI), with accessory genes (chrJ, chrK, chrL) enhancing resistance up to 200 mM chromate concentrations. Similar mechanisms, including , confer tolerance by sequestration and extrusion, with some strains reaching minimum inhibitory concentrations exceeding 5 mM. Plasmid-borne genes for degradation further support this, with recent isolates from landfills (2025) revealing 11 protein-coding genes homologous to plastic-degrading enzymes, such as alkane hydroxylases and esterases, facilitating partial breakdown of and . The genomic architecture of Arthrobacter underscores its environmental adaptability, featuring large chromosomes (3–5 Mb) alongside multiple replicons, including linear and circular plasmids that promote (HGT) for stress response. These plasmids, often conjugative and ranging from 8–90 kb, harbor transposable elements and partitioning systems that facilitate the acquisition of and catabolic modules, as seen in strains where identical plasmids occur across isolates, indicating active HGT in oligotrophic soils. Biofilm formation and in Arthrobacter enhance community-level in heterogeneous matrices, with luxR-related regulators coordinating collective behaviors under nutrient scarcity. Genomes encode up to 16 luxR solos, including airR and aiaR types, which respond to environmental signals like N,N-dimethylhexadecylamine to modulate and surface attachment, fostering development and resource sharing in consortia. This QS-mediated , prevalent in rhizospheric and soils, improves resilience to fluctuating conditions by enabling synchronized for production.

Applications and Interactions

Bioremediation and Pollutant Degradation

Arthrobacter species have demonstrated significant potential in through their ability to reduce toxic (Cr(VI)) to the less mobile and toxic trivalent form (Cr(III)). For instance, Crystallibacter crystallifaciens (formerly Arthrobacter crystallopoietes) ES32, isolated from chromium-contaminated environments, employs chromate reductase enzymes to achieve up to 90% reduction of Cr(VI) within 12 hours in both intact cells and cell-free extracts, making it effective for treating contaminated soils under stressed conditions. Other strains, such as Arthrobacter sp. Sphe3, further support this capability by reducing Cr(VI) in the presence of glucose as a carbon source, with optimized conditions enhancing bioremoval efficiency in suspended cultures. These reductions occur via enzymatic mechanisms that utilize NADH or other cofactors, contributing to the of industrial effluents and sites. In the degradation of organic pollutants, Pseudarthrobacter chlorophenolicus (formerly Arthrobacter chlorophenolicus) A6 excels at breaking down 4-chlorophenol (4-CP), a common environmental , through pathways involving hydroxyquinol intermediates and achieving complete mineralization at concentrations up to 800 mg/L under aerobic conditions. This strain's genome contains gene clusters encoding monooxygenases and dioxygenases, which facilitate the initial and ring cleavage of aromatic compounds, including capabilities for degrading related aromatics like polychlorinated biphenyls (PCBs) via similar oxidative processes. These enzymatic systems enable P. chlorophenolicus to adapt its degradation activity based on environmental cues, such as temperature fluctuations from 5°C to 28°C, without significant loss in efficiency. Recent advances highlight the expanding role of Arthrobacter in addressing emerging contaminants. Strains isolated from landfills, such as Arthrobacter sp. from soil, have shown potential for biodegradation, with whole-genome sequencing revealing genes for oxidative enzymes that support and (LDPE) degradation through formation and surface colonization. In consortia with other bacteria like , Arthrobacter sp. enhances LDPE film biodegradation by promoting greater development and enzymatic breakdown, as demonstrated in enrichment studies. For heavy metal sequestration, Arthrobacter sp. EIKU3 from soils accumulates alongside remediation, bioaccumulating metals from leached e-waste liquors to mitigate pollution in affected areas. As of 2025, Arthrobacter strains have been incorporated into bacterial consortia for efficient of crude oil-contaminated soils, achieving enhanced degradation rates in field-like conditions. Bioaugmentation strategies leverage Arthrobacter strains by inoculating them directly into polluted sites to accelerate contaminant removal. Field trials with P. chlorophenolicus (formerly A. chlorophenolicus) A6 in 4-CP-contaminated soils have demonstrated effective cleanup, with the inoculum degrading high concentrations and reducing residues by up to 90% within weeks through stable formulation methods that maintain viability for months. Similarly, with Paenarthrobacter aurescens (formerly Arthrobacter aurescens) TC1 in terbuthylazine-spiked natural soils achieves rapid remediation, with 80-100% removal in 3 days under optimized conditions, highlighting for s-triazine herbicides. These approaches often yield 50-80% overall contaminant reductions in and pilot-scale tests, depending on site-specific factors like availability. Despite these strengths, Arthrobacter species face limitations in bioremediation applications, primarily due to their relatively slower growth rates compared to faster-degrading bacteria like Pseudomonas species. This necessitates optimization strategies, such as nutrient supplementation or co-inoculation, to enhance survival and activity in nutrient-poor or competitive field environments. Additionally, in situ success can be limited by factors like low maintenance energy efficiency during adaptation to pollutants, requiring further formulation improvements for long-term stability.

Industrial and Agricultural Uses

Arthrobacter species have been utilized in industrial fermentation processes for the production of L-glutamate, a key amino acid used as a food additive in products like monosodium glutamate. Strains such as A. globiformis employ molasses or starch-derived carbon sources in submerged fermentation, achieving yields of up to 87.5 g/L under optimized conditions of pH 5.0 and 30°C incubation for three days. This process leverages the bacterium's metabolic efficiency in converting sugars to glutamic acid, contributing to large-scale manufacturing for flavor enhancement in the food industry. In biotechnology, enzymes derived from Arthrobacter play critical roles in molecular biology and prebiotic synthesis. The AluI restriction endonuclease from A. luteus recognizes the sequence AGCT and is widely applied in DNA cloning due to its ability to generate blunt-ended fragments suitable for ligation. Additionally, inulin fructotransferase (often referred to as inulase) from Arthrobacter sp. H65-7 catalyzes the conversion of inulin to difructose anhydride III (DFA III), a prebiotic compound used in functional foods for its probiotic-like effects on gut health. Industrial-scale production of DFA III from chicory-derived inulin using this enzyme has been established, highlighting its viability for prebiotic manufacturing. Agriculturally, Arthrobacter strains promote growth through mechanisms such as solubilization and (IAA) production, enhancing nutrient availability and root development. For instance, Arthrobacter sp. GN70 solubilizes insoluble phosphates and produces up to 50.3 µg/mL IAA, leading to improved and yield in phosphorus-limited soils. Recent studies demonstrate yield increases of 20-30% in crops like cactus pear (), where Arthrobacter enhances cladode growth, fruit quality, and properties under drought stress. Similar benefits have been observed in , with bacterial boosting overall vigor and productivity through these growth-promoting traits. As of 2025, functional strains of Arthrobacter have been shown to enhance growth and quality when combined with in agricultural inoculants. In the food industry, Arthrobacter contributes positively through pigment production, notably bacterioruberin, a C50 carotenoid serving as a natural red colorant with antioxidant properties for processed foods. Extracts from Arthrobacter sp. isolates provide stable pigmentation, reducing reliance on synthetic dyes in applications like beverages and confectionery. As of 2025, strains producing red pigments have been identified for potential use in replacing synthetic colorants across chemical and food industries. However, certain strains act as spoilers in dairy products, contributing to off-flavors and texture defects in milk and cheese due to their proteolytic and lipolytic activities as contaminants. Recent developments include the isolation of antibacterial compounds from desert-derived Arthrobacter strains, offering potential for biopesticides in agriculture. Strains from the Great Gobi Desert exhibit strong inhibition against plant and human pathogens, with resistance to heavy metals and salts enabling their use in formulating eco-friendly pest control agents. These 2024 findings underscore the genus's expanding role in sustainable biopesticide development.

Diversity of Species

Number and Classification of Species

The genus Arthrobacter encompasses 74 validly published species as of November 2025, based on the List of Prokaryotic names with Standing in (LPSN). This count reflects ongoing taxonomic expansions, including the addition of Arthrobacter yangruifuii in 2020, Arthrobacter zhaoxinii and Arthrobacter jinronghuae in 2023, Arthrobacter horti in 2024, and several other novel species, alongside putative species emerging from 2024 genomic surveys of environmental isolates. New species proposals are rigorously validated through publication in the International Journal of Systematic and Evolutionary Microbiology (IJSEM), ensuring compliance with international nomenclature standards. Classification within the relies on a polyphasic taxonomic approach that integrates phylogenetic, genomic, and chemotaxonomic . Affiliation to Arthrobacter typically requires 16S rRNA similarity exceeding 98.7%, while delineation demands DNA-DNA hybridization (DDH) values below 70% and average nucleotide identity (ANI) below 95-96% between strains. Chemotaxonomic markers, such as the predominant menaquinone MK-9(H₂) and specific peptidoglycan compositions (e.g., L-Lys-L-Ser-D-Glu type A3α), further support delineation and distinguish Arthrobacter from related genera in the family . The exhibits significant heterogeneity, prompting taxonomic revisions; it was emended in to exclude glutamic acid-producing , which were reclassified into novel genera like Glutamicibacter and Paenarthrobacter based on phylogenetic and chemotaxonomic discrepancies. Recent analyses have highlighted distinct genomic clusters, fueling ongoing proposals for additional splits to better reflect evolutionary divergence among isolates. Most are soil-derived, though isolates from food matrices, extreme environments (e.g., polar regions), and occasional clinical sources underscore the genus's ecological breadth.

Notable Species and Their Traits

Arthrobacter globiformis, the of the , is a ubiquitous isolate known for its distinctive rod-coccus growth cycle, transitioning from rod-shaped cells during to coccoid forms in stationary phase, making it a for studying bacterial . This species has been utilized in biotechnological applications, particularly for the fermentative production of L-glutamic acid under biotin-limited conditions, yielding up to 0.45 moles per mole of glucose consumed. Arthrobacter chlorophenolicus stands out for its ability to degrade high concentrations of 4-chlorophenol, up to 350 ppm, as a sole carbon source, positioning it as a key player in studies of chlorinated pollutants. Its complete was sequenced in 2009, revealing genes involved in degradation pathways that enhance its environmental resilience and application potential. Arthrobacter crystallopoietes, isolated from polluted soils, exhibits remarkable reduction capabilities, converting up to 90% of Cr(VI) to less toxic Cr(III) within 12 hours via both intact cells and cell-free extracts. This species is notable for its crystal-like colony formation, attributed to the extracellular deposition of crystalline pigments when grown on substrates like 2-hydroxypyridine, which contributes to its distinctive morphology. Arthrobacter luteus is recognized as the source of the AluI restriction endonuclease, which cleaves DNA at AG^CT sequences and is widely used in molecular biology for DNA mapping and cloning. Characterized by its yellow pigmentation due to carotenoid production, this species is commonly found in airborne dust and environmental samples, aiding in studies of microbial dispersal. Among recent isolates, Arthrobacter sp. PAMC25564, recovered from soil, has a 2021-sequenced that highlights cold-adaptation mechanisms, including an expanded repertoire of carbohydrate-active enzymes (CAZymes) for and metabolism to maintain at low temperatures. Similarly, an Arthrobacter sp. from the landfill in the , with its 2025 whole-genome sequence, reveals genes potentially involved in and , supporting its role in plastic waste management. While generally non-pathogenic, certain Arthrobacter species, including A. cumminsii and A. woluwensis, have been implicated in rare opportunistic infections, such as bacteremia and urinary tract infections in immunocompromised patients, underscoring their emerging clinical relevance despite low virulence.

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