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Galactocele
Galactocele
Galactocele
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Galactocele
Other namesLacteal cyst, Lactocele, Galactocoele, Milk cyst
SpecialtyGynaecology Edit this on Wikidata

A galactocele (also called lacteal cyst or milk cyst) is a retention cyst containing milk or a milky substance that is usually located in the mammary glands. They can occur in women during or shortly after lactation.[1]

They present as a firm mass, often subareolar, and are caused by the obstruction of a lactiferous duct. Clinically, they appear similar to a cyst upon examination.[2] The duct becomes more distended over time by epithelial cells and milk. It may rarely be complicated by a secondary infection and result in abscess formation. These cysts may rupture leading to formation of inflammatory reaction and may mimic malignancy.[citation needed]

Once lactation has ended the cyst should resolve on its own without intervention. A galactocele is not normally infected as the milk within is sterile and has no outlet through which to become contaminated. Treatment is by aspiration of the contents or by excision of the cyst. Antibiotics are given to prevent infection.[3]

Galactoceles may be associated with oral contraceptive use.[4] They have been known to present, although rarely, after Breast augmentation and Breast reduction.[5]

References

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Galactocele

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from Grokipedia
A galactocele, also known as a lactocele or retention , is a benign, fluid-filled cystic that develops in the breast due to obstruction of a , leading to accumulation of or milky substance, and it most commonly occurs in women who are lactating or have recently ceased . These cysts are typically painless, palpable lumps that range from 1 to 6 cm in diameter, presenting as round, movable masses with a soft to firm consistency, and they may fluctuate in size based on hormonal influences or production. Galactoceles arise from a combination of factors requiring secretory , stimulation, and ductal blockage, often linked to challenges such as infrequent , stasis, or external factors like hormonal contraceptives, trauma, or prior . They represent the most common benign during , with an estimated incidence of about 4% among benign breast conditions and 4-5% of biopsies for BI-RADS category 4 lesions, predominantly affecting young women in their reproductive years. Although usually unilateral, they can be bilateral or multiple, and complications such as infection leading to formation are rare but possible if untreated. Diagnosis is primarily achieved through clinical examination combined with , where ultrasonography reveals a well-defined cystic lesion often with low-level internal echoes or fat-fluid levels, while may show a radiolucent resembling a pseudolipoma; confirmation comes from yielding thick, milky fluid positive for mucicarmine staining. Management is conservative for asymptomatic cases, as many resolve spontaneously, but symptomatic or enlarging cysts may require aspiration or catheter drainage, with surgical excision reserved for recurrent or persistent lesions; antibiotics are used if secondary occurs.

Overview

Definition

A galactocele is defined as a benign, milk-filled retention that forms in due to obstruction of a . This cystic contains milky fluid composed of and protein secretions from the mammary , distinguishing it from other breast cysts that hold . The term "galactocele" derives from words galatea, meaning milky white, and cele, meaning pouch or swelling. Galactoceles primarily occur in lactating or recently lactating women, where ductal obstruction leads to accumulation during or shortly after . Rare cases have been reported in non-lactating individuals, including men, infants, and prepubertal girls, often associated with transient hormonal influences such as elevated levels. Clinically, a galactocele typically presents as a solitary, well-circumscribed, mobile, and nontender mass, often located in the retroareolar region. These lesions are usually painless and may fluctuate in size, commonly measuring 1 to 2 cm but ranging up to 5 cm or more in some instances.

Epidemiology

Galactocele is a rare benign , representing an estimated 4% of cases among patients presenting with benign breast conditions in nonhospital settings. It accounts for approximately 4-5% of biopsies performed on category 4 lesions, though exact global incidence rates remain unknown due to frequent spontaneous resolution and underreporting of asymptomatic cases. As the most common benign identified in lactating individuals, galactoceles are primarily linked to physiological changes during , with many going undiagnosed unless they cause palpable lumps or other symptoms. The condition predominantly affects women in their 20s to 40s, with peak incidence in the fourth and fifth decades, occurring during , active , or shortly after . It is almost exclusively seen in parous women, aligning with the reproductive and phases of life, and extremely rare in men—limited to isolated reports in male infants or adults with hyperprolactinemia—and extremely rare in prepubertal individuals, limited to isolated reports in infants and children of both sexes. Key risk factors include abrupt cessation of , which promotes milk stasis and obstruction of lactiferous ducts. Additional contributors encompass , such as improper technique or infant-related contraindications to nursing, hormonal stimuli like elevated levels (e.g., from ), and prior trauma or augmentation. No significant geographic or seasonal variations in galactocele occurrence have been documented.

Pathophysiology

Causes

A galactocele primarily arises from the obstruction of a in lactating or recently lactating women, resulting in the accumulation of within a cystic structure. This ductal blockage is often caused by inspissated , cellular debris, or epithelial proliferation that prevents normal milk flow. The formation requires a combination of secretory breast , stimulation, and persistent ductal occlusion. Contributing factors include trauma to the , such as from infant bites during feeding or external pressure from tight , which can compress and obstruct ducts. Incomplete or infrequent breast emptying, often due to difficulties in breastfeeding like poor or infant conditions (e.g., cleft ), leads to milk stasis and promotes development. Use of combined oral contraceptives may exacerbate this by stimulating breast in the presence of ductal issues. Rare causes encompass ductal occlusion secondary to prior infections, such as , which can produce and scarring. Endocrine imbalances, including elevated levels from conditions like , can trigger milk production and subsequent obstruction even outside typical . In non-lactating individuals, galactoceles may occur idiopathically or in association with hormonal therapies that mimic , such as those used in women or for other endocrine treatments. Non-lactational cases are uncommon but documented in adult men with hyperprolactinemia and in neonates (particularly males) due to transplacental transfer or fetal pituitary issues. Post-surgical scenarios, including where incisions injure ducts, can also precipitate galactocele formation regardless of status.

Histological Features

Galactoceles present as well-circumscribed, oval lesions measuring 1 to 6 cm in diameter on gross examination, with a cut surface revealing multiple variable-sized filled with thin yellow or milky fluid that may appear thick and chalky if inspissated. The cyst walls are typically thin and fibrous, lined by flattened ductal , and the contents consist of a creamy, milk-like material containing fat globules, proteins such as and , lipids, mucins, lysozymes, and cellular debris including necrotic cells and nuclear fragments, but lacking malignant cells. Microscopically, the cysts are formed by dilated, anastomosing ductal channels lined by cuboidal or flattened epithelial cells with regular nuclei and cytoplasmic vacuolations due to lipid accumulation, often accompanied by apocrine metaplasia in the . The surrounding fibrous wall shows lactational changes and mild with minimal inflammatory infiltrate, though foamy macrophages and chronic inflammation may appear in adjacent tissue if cyst contents leak, potentially leading to . The fluid tests positive for , confirming its milky, -rich composition. A notable variant is the crystallizing or inspissated galactocele, characterized by thick, chalky white material containing birefringent crystals that appear purple on hematoxylin-eosin and require surgical excision if aspiration fails. Unlike serous cysts, galactoceles are distinguished by their unique milky, lipid-laden content and the absence of neoplastic features, with no significant inflammatory response unless secondary occurs.

Clinical Presentation

Signs and Symptoms

A galactocele typically presents as a palpable, smooth, well-defined lump that is round and movable, often located in the retroareolar or subareolar region. The mass is usually solitary but can be multiple or bilateral, with a consistency ranging from soft to moderately firm, and its size may fluctuate, sometimes enlarging gradually or rapidly. Most galactoceles are and painless, with patients reporting no discomfort unless the lesion is rapidly enlarging or secondarily infected, in which case mild tenderness may occur. There are typically no associated skin changes, such as or dimpling, and is uncommon, but milky discharge may occur in some cases; systemic symptoms like fever are rare and suggest complication. These lesions commonly develop in lactating women, appearing weeks to months postpartum or during the process, often following cessation of . They can also develop during the third trimester of or while actively . The lump may decrease in size after sessions due to pressure relief.

Differential Diagnosis

Galactoceles are benign milk-filled cysts that can mimic several other conditions, necessitating careful differentiation based on clinical history, , and . Benign mimics include simple cysts, which are typically anechoic on without the fat-fluid levels or milky content characteristic of galactoceles. Fibroadenomas present as firm, mobile, ovoid masses with smooth borders and homogeneous , lacking the cystic nature and lactation association of galactoceles. Lactational abscesses, often complicating , are distinguished by associated , severe pain, and systemic symptoms like fever, unlike the usually painless, nontender lump of a galactocele. Malignant considerations include breast carcinoma, which may appear as a firmer mass with irregular margins and suspicious imaging features, prompting to exclude in the absence of a clear history. Phyllodes tumors, though rare, can mimic galactoceles in lactating women as rapidly growing, well-circumscribed masses but are typically solid and require histologic confirmation due to potential for . Other differentials encompass lumps associated with , such as those from ductal ectasia or hyperprolactinemia, which may present with milky discharge but lack the discrete cystic structure of galactoceles. is considered when a subareolar lump is accompanied by bloody , differentiating it from the typically non-discharge-producing galactocele. A history of recent strongly favors galactocele, while aids in excluding solid lesions by demonstrating cystic features. The painless lump typical of galactocele further guides differentiation from more symptomatic mimics.

Diagnosis

Clinical Evaluation

The clinical evaluation of a suspected galactocele begins with a detailed history to identify risk factors and contextualize the presentation. Clinicians should inquire about the patient's status, including whether the condition arose during active , in the third trimester of , or following , as galactoceles primarily develop in lactating or recently lactating women due to obstruction. Additional history should cover duration and challenges, such as primiparity, difficult latching, or reliance on feeding, which may lead to incomplete milk evacuation and formation. Trauma to the breast, including aggressive manipulation or external , should also be assessed, as it can precipitate duct blockage. Furthermore, any history of endocrine disorders, such as hyperprolactinemia from conditions like , warrants exploration, though these are less common contributors. Physical examination focuses on characterizing the breast mass and surrounding structures to differentiate benign features from concerning ones. The exam should evaluate the lump's mobility, which is typically well-defined and movable, often located in the retroareolar region with sizes ranging from 1 to 2 cm but potentially exceeding 10 cm. Tenderness is usually absent or mild, though discomfort may occur; severe pain suggests possible . Assessment includes for , which are generally non-enlarged in uncomplicated cases, and inspection for skin or changes, such as or milky discharge, while a bilateral examination helps rule out or multifocal involvement. Patients often present with a palpable, soft, cystic mass that may fluctuate in size with activity. Certain findings during serve as red flags necessitating urgent further investigation. Rapid growth of the , fixation to surrounding tissues, or associated discharge—such as bloody rather than milky—raises suspicion for or other and prompts immediate referral. The history and play a pivotal role in guiding management decisions, particularly in cases with low suspicion for . A classic presentation supports conservative or proceeding to aspiration for symptomatic relief, while red flags direct toward multidisciplinary to exclude serious conditions.

Imaging Techniques

Ultrasound serves as the first-line imaging modality for evaluating suspected galactoceles, particularly in lactating or recently lactating women under 30 years old, due to its high sensitivity, lack of , and ability to differentiate benign cysts from malignancies. On , galactoceles typically appear as well-circumscribed, round or oval anechoic or hypoechoic cystic masses with posterior acoustic enhancement; a characteristic fat-fluid level may be visible, with the fat layer appearing hypoechoic or hyperechoic superiorly. In cases with proteinaceous or inspissated content, the lesion can exhibit a heterogeneous or "pseudosolid" appearance, though color Doppler usually shows no internal . Approximately 50% present as purely cystic or multicystic, 37% as mixed cystic-solid, and 13% as solid-like, but suspicious features such as indistinct margins or warrant further assessment. Mammography is recommended as an adjunct or initial study in women over 30 or when findings are equivocal, though its utility is limited in younger patients with . Galactoceles on often manifest as well-defined, rounded opacities with a fat-fluid level best appreciated on the 90-degree mediolateral view, potentially mimicking a if fat content is high or showing peripheral rim calcifications in chronic cases. The appearance varies based on viscosity: fresh may produce a radiolucent pseudolipoma, while thicker material can resemble a . Magnetic resonance imaging (MRI) is rarely employed for galactoceles unless the case is complex, such as in dense breasts or high-risk patients requiring further characterization. On MRI, these lesions demonstrate a fat-fluid level with high signal intensity on non-fat-saturated T1-weighted images due to the protein and content, and variable enhancement patterns depending on the composition. Imaging limitations include significant overlap in appearances with other benign cysts, abscesses, or even malignancies, necessitating clinical correlation with lactation history. Galactoceles are typically categorized as BI-RADS 2 (benign), but atypical features may elevate to BI-RADS 4, prompting aspiration for confirmation.

Fine-Needle Aspiration

Fine-needle aspiration (FNA) is a minimally invasive diagnostic procedure commonly employed to confirm the diagnosis of galactocele, particularly when imaging suggests a cystic lesion in lactating or postpartum women. Performed on an outpatient basis, the procedure typically involves ultrasound guidance to target the well-defined, cystic mass, using a thin 21- or 22-gauge needle attached to a syringe for fluid extraction. The aspiration yields a characteristic thick, milky white fluid, which is often both diagnostic and therapeutic by reducing the lesion size and alleviating symptoms such as pain or discomfort. In cases of inspissated or crystallizing galactoceles, the aspirate may appear chalky or gritty, requiring multiple passes to obtain sufficient material for analysis. Cytological examination of the aspirated fluid reveals an acellular or sparsely cellular rich in , with frothy lipid micelles, amorphous proteinaceous material, and necrotic debris. Occasional foamy macrophages with degenerative changes and benign ductal epithelial cells may be present, but the absence of cells or mitotic activity supports the benign nature of the . In rare variants such as crystallizing galactoceles, refractile crystals—often or —appear as purple or needle-like structures under stains like Giemsa, hematoxylin and eosin, or Papanicolaou, exhibiting under polarizing . If the fluid is pus-like rather than milky, additional analysis for , including , is indicated to differentiate from . FNA is indicated for symptomatic galactoceles causing , enlargement, or tenderness, or when imaging findings are equivocal and must be excluded, especially in non-lactating patients. The procedure's high specificity for benignity stems from the milky aspirate and cytological features, often obviating the need for core biopsy unless atypical cells or solid components are noted. Diagnostic yield is particularly reliable when correlated with clinical history and showing a cystic appearance, achieving confirmation in the majority of cases without further intervention.

Management

Conservative Approaches

For uncomplicated, galactoceles, is the primary conservative management strategy, as these benign milk-filled cysts often resolve spontaneously without intervention. This approach is particularly suitable for stable lesions that do not cause discomfort or interfere with , allowing time for natural regression tied to the stabilization of -related hormonal changes. In the vast majority of cases, spontaneous resolution occurs following , though timelines vary based on individual factors such as lesion size and ongoing . Supportive measures can complement by promoting comfort and facilitating drainage. Continued or pumping on demand is encouraged to maintain flow and prevent stagnation, which may aid in resolution. Additional non-invasive techniques, such as applying warm compresses and gentle directed toward the nipple during feeding or pumping sessions, can help encourage milk drainage and alleviate any mild associated tenderness. Ice packs and supportive bras may also be used intermittently for pain relief if swelling is present, while avoiding excessive pumping to prevent further duct obstruction. Regular follow-up is essential to monitor lesion stability and detect any changes warranting further evaluation. Regular clinical examinations combined with ultrasound imaging are recommended to monitor lesion stability, with frequency determined by clinical judgment or if symptoms develop, to assess size, characteristics, and regression progress. This serial monitoring helps confirm the benign nature of the galactocele and ensures timely adjustment of management if growth or complications occur. Patient education plays a key role in conservative management, providing reassurance about the benign, self-limiting course of most galactoceles. Individuals should be informed that these lesions pose no risk to or and often regress without treatment post-weaning. Guidance on proper techniques, hygiene, and signs necessitating prompt medical attention—such as increasing pain, rapid growth, skin changes, or fever—empowers patients to participate actively in monitoring and seek care appropriately.

Interventional Treatments

For symptomatic galactoceles causing pain or significant discomfort, therapeutic aspiration is the initial interventional approach, involving ultrasound-guided fine-needle drainage to relieve pressure and confirm the through the extraction of thick, y fluid. This procedure is minimally invasive, typically performed in an outpatient setting using a 18- to 22-gauge needle, and can provide immediate symptom relief. However, recurrence due to re-accumulation of milk is common, with rates reported up to 40% in small clinical series, often necessitating repeated aspirations. For cases requiring repeated drainage, placement under ultrasound guidance may be preferred to minimize risk. Surgical excision, or simple , is reserved for cases of recurrent or persistent galactoceles unresponsive to multiple aspirations, infected lesions requiring drainage, or those with diagnostic uncertainty to rule out . For infected galactoceles, drainage should be accompanied by antibiotics, such as 500 mg four times daily for 10-14 days. The procedure involves local or general , excision of the wall to prevent re-accumulation, and preservation of surrounding tissue to maintain if applicable. It is particularly indicated when the contents have become inspissated or crystallized, making aspiration ineffective. Post-procedure care following aspiration or excision emphasizes supportive measures to promote healing and prevent complications. Patients are advised to wear a supportive for compression to minimize swelling and support tissue, apply ice packs intermittently for pain control, and continue or pumping on the affected side to encourage drainage and reduce stagnation. Close monitoring for signs of , such as increased redness, warmth, or fever, is essential, with follow-up or clinical evaluation recommended if symptoms persist.

Prognosis

Outcomes

Galactoceles typically follow a benign course, with most cases resolving spontaneously upon cessation of due to stabilization of hormonal changes and reduction in milk production. In the majority of instances, no intervention is required, as spontaneous resolution occurs without complications in lactating or recently lactating women. Recurrence is uncommon overall, particularly after ends, though it may be more likely if persistent ductal obstruction or underlying anatomical issues remain unaddressed, and repeated aspirations may be needed if refilling occurs. Long-term, galactoceles exert no adverse impact on future pregnancies or capabilities, and progression to malignant or other significant pathologies is exceedingly rare. This excellent is supported by clinical observations in lactating populations, where the vast majority experience complete resolution without sequelae.

Complications

Galactoceles are generally benign and , but secondary bacterial can occur, leading to acute or breast formation. This complication arises from pathogens such as or streptococci entering the , often facilitated by unsterile procedures like aspiration or in the presence of breast implants. Infected galactoceles present with systemic signs including fever, , and localized tenderness over the , necessitating prompt intervention to prevent further spread. Rupture of a galactocele is a rare event, typically occurring spontaneously, post-trauma, or following interventional drainage, which can result in local , milk , or granulomatous reactions such as xanthogranulomatous . Such ruptures may cause leakage of milky contents into surrounding tissue, triggering an inflammatory response that mimics more serious conditions like or . Case reports highlight this as an uncommon but challenging , particularly in infected or longstanding cysts. Misdiagnosis poses a significant with galactoceles, as their as firm, palpable masses can resemble , especially if atypical features like or occur, leading to unnecessary biopsies or surgical excisions if is not confirmatory. Crystallizing galactoceles, in particular, may appear solid on imaging and cytology, prompting such interventions. Clinicians must integrate , , and cytological analysis to differentiate benign lesions from , avoiding oversight of suspicious . Large galactoceles can cause cosmetic concerns due to visible or distortion, particularly in postpartum women or those with prior augmentation mammoplasty, potentially impacting and requiring intervention for aesthetic restoration. Additionally, rare associations exist between galactoceles and endocrine disorders, such as , where hyperprolactinemia may exacerbate cyst formation by promoting milk stasis and ductal obstruction; resolution has been observed following treatment of the underlying . Aspiration of galactoceles carries a minor risk of introducing infection, underscoring the need for sterile technique.

References

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