The performance of Roxanne by the Police to open the show promoted the start of their reunion tour.
Multiple nominees and wins (award nominations/wins)
- Mary J. Blige (8/3)
- Dixie Chicks (5/5)
- John Mayer (5/2)
- James Blunt (5/0)
- Red Hot Chili Peppers (4/3)
- Gnarls Barkley (4/2)
- Justin Timberlake (4/2)
- Carrie Underwood (3/2)
Bold type indicates the winner out of the list of nominees.
- Record of the Year
- Album of the Year
- Taking the Long Way – Dixie Chicks
- St. Elsewhere – Gnarls Barkley
- Danger Mouse, producer; Ben H. Allen, Danger Mouse & Kennie Takahashi, engineers/mixers; Mike Lazer, mastering engineer
- Continuum – John Mayer
- Stadium Arcadium – Red Hot Chili Peppers
- FutureSex/LoveSounds – Justin Timberlake
- Nate (Danja) Hills, Jawbreakers, Rick Rubin, Timbaland & Justin Timberlake, producers; Jimmy Douglass, Serban Ghenea, Padraic Kerin, Jason Lader, Andrew Scheps, Timbaland & Ethan Willoughby, engineers/mixers; Herb Powers, Jr., mastering engineer
- Song of the Year
- Best New Artist
- Grammy Award for Best Recording Package[2]
- Best Alternative Music Album
- Best Traditional Blues Album
- Best Contemporary Blues Album
- Best Female Country Vocal Performance
- Best Male Country Vocal Performance
- Best Country Performance by a Duo or Group with Vocal
- Best Country Collaboration with Vocals
- Best Country Instrumental Performance
- Best Country Song
- Best Country Album
- Best Bluegrass Album
- Best Dance Recording
- Best Electronic/Dance Album
- Best Traditional Folk Album
- Best Contemporary Folk/American Album
- Best Native American Music Album
- Best Hawaiian Music Album
- Best Gospel Performance
- Best Gospel Song
- Best Southern, Country or Bluegrass Gospel Album
- Best Traditional Gospel Album
- Best Contemporary R&B Gospel Album
- Best Rock or Rap Gospel Album
- Best Contemporary Jazz Album
- Best Jazz Vocal Album
- Best Jazz Instrumental Solo
- Best Jazz Instrumental Album, Individual or Group
- Best Large Jazz Ensemble Album
- Best Latin Jazz Album
Best Latin Pop Album:
Best Latin Rock, Alternative Or Urban Album:
Best Tropical Latin Album:
Best Mexican / Mexican-American Album:
Best Tejano Album:
Best Norteño Album:
Best Banda Album:
- Best New Age Album
- Best Female Pop Vocal Performance
- Best Male Pop Vocal Performance
- Grammy Award for Best Pop Performance by a Duo or Group with Vocals
- Best Pop Collaboration With Vocals
- Best Pop Instrumental Performance
- Best Pop Instrumental Album
- Best Pop Vocal Album
- Best Female R&B Vocal Performance
- Best Male R&B Vocal Performance
- Grammy Award for Best R&B Performance by a Duo or Group with Vocals
- Best Traditional R&B Vocal Performance
- Best Urban/Alternative Performance
- Best R&B Song
- Best R&B Album
Best Contemporary R&B Album
Best Rap Solo Performance
- Best Rap Performance By A Duo Or Group
Best Rap/Sung Collaboration
Best Rap Song
Best Rap Album
- Best Reggae Album
- Best Solo Rock Vocal Performance
Best Rock Performance by a Duo or Group with Vocal
- Best Hard Rock Performance
- Best Metal Performance
- Best Rock Instrumental Performance
- Best Rock Song
- Best Rock Album
- Best Traditional Pop Vocal Album
Best Musical Album for Children
Best Spoken Word Album for Children
- Blah Blah Blah: Stories About Clams, Swamp Monsters, Pirates & Dogs – Bill Harley
- Christmas In The Trenches – John McCutcheon
- Disney's Little Einsteins Musical Missions (Various Artists) – Ted Kryczko & Ed Mitchell, producers
- Peter Pan – Jim Dale
- The Witches – Lynn Redgrave
Best Spoken Word Album (Includes Poetry, Audio Books & Story Telling)
- Best Comedy Album (For comedy recordings, spoken or musical)
- Best Classical Album
- Best Orchestra Performance
- Best Opera Recording
- "Golijov: Ainadamar: Fountain Of Tears"
- Best Choral Performance
- "Pärt: Da Pacem"
- Paul Hillier, conductor; Brad Michel & Robina G. Young, producers; Brad Michel, engineer/mixer (Estonian Philharmonic Chamber Choir)
- Best Instrumental Soloist(s) Performance (with Orchestra)
- Best Instrumental Soloist Performance (without Orchestra)
- Chopin: Nocturnes
- Maurizio Pollini, soloist; Christopher Alder, producer; Klaus Hiemann & Oliver Rogalla Von Heyden, engineers
- Best Chamber Music Performance
- "Intimate Voices"
- Emerson String Quartet (Eugene Drucker, Lawrence Dutton, David Finckel & Philip Setzer), ensembles; Da-Hong Seetoo, producer
- Best Small Ensemble Performance
- "Padilla: Sun Of Justice"
- Fred Vogler, producer; Peter Rutenberg, conductor; Los Angeles Chamber Singers' Capella (Corey Carleton), ensembles; Fred Vogler, engineer
- Best Classical Vocal Performance
- Best Classical Contemporary Composition
- "Golijov: Ainadamar: Fountain Of Tears"
- Best Classical Crossover Album
- Best Short Form Music Video
- Best Long Form Music Video