Madden NFL 08 is a 2007 American football sports video game developed primarily by EA Tiburon and published by EA Sports. Based on the National Football League (NFL), it is the 2007 entry in the Madden NFL series. EA marketed the game around a new "Read and React" system, which used on-field skill icons—called "weapons"—to identify individual player strengths and possible matchups; the game also added Hit Stick 2.0 and a branching animation system for tackles and catches.

Tennessee Titans quarterback Vince Young appears on the North American cover. The game was released in North America on August 14, 2007, for Xbox 360, Wii, PlayStation 3, PlayStation 2, Nintendo DS, PlayStation Portable, Xbox, GameCube, Microsoft Windows, and mobile phones. A Mac OS X version followed after EA delayed its planned August release. A Spanish-language version, with San Diego Chargers defensive end Luis Castillo on the cover and ESPN Deportes announcer Álvaro Martín providing commentary, was released for PlayStation 2 and Xbox 360 in December 2007.

The Xbox 360 and PlayStation 3 versions received generally favorable reviews, while other versions received mixed to generally favorable reviews. According to EA, Madden NFL 08 sold 4.5 million copies in the quarter ending September 30, 2007, making it EA's best-performing title for that quarter.

EA announced Young as the game's North American cover athlete on April 18, 2007; the company said he was the youngest player to appear on a Madden cover at that time. At launch, EA described the game as available on ten platforms in North America. Earlier in 2007, Apple had announced that Madden NFL 08 and Tiger Woods PGA Tour 08 would ship simultaneously with their PC counterparts as part of EA's return to Mac gaming. After the other versions launched in August, EA told AppleInsider that the Mac OS X version had been pushed to September or October.

The Spanish-language edition was announced in October 2007 and released for PlayStation 2 and Xbox 360 on December 11, 2007. It featured Spanish-language commentary by Álvaro Martín and cover art with Luis Castillo. EA reported on November 1, 2007, that Madden NFL 08 had sold 4.5 million copies and was the company's best-performing title for the quarter ending September 30, 2007.

Madden NFL 08 is an NFL football simulation in which players control teams through exhibition games, season play, franchise modes and online multiplayer. Its central new feature is the Read and React system, known in-game as "weapons". Star players can receive icons identifying specialties such as Smart Quarterback, Possession Receiver, Spectacular Catch Receiver and Shutdown Corner; the system can also be disabled in the settings. The icons are intended to highlight matchup advantages before the snap and make star players more distinct on the field.

Hit Stick 2.0 allows players to deliver high or low tackles by moving the analog stick up or down. The game also added a branching animation system for outcomes such as mid-air collisions, one-handed catches, sideline catches, hurdles and gang tackles. A revised fatigue system makes repeated scrambling by quarterbacks less effective and can also affect teams playing in extreme weather conditions.

In Superstar Mode, players can create a player, use select rookies from the 2007 NFL draft or import a player from NCAA Football 08's Campus Legend mode. Unlike previous versions in which core attributes were generated through fictional parents, key attributes are assigned during character creation. The game also includes a trophy room for completing in-game tasks and allows trophies to be wagered in online head-to-head games; high-level players can earn customizable EA Challenge rings.