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Haloxazolam
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| Clinical data | |
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| Trade names | Somelin (JP) |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Excretion | Renal |
| Identifiers | |
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| CAS Number | |
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| DrugBank | |
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| KEGG | |
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| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C17H14BrFN2O2 |
| Molar mass | 377.213 g·mol−1 |
| 3D model (JSmol) | |
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Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.[2][3][4] It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment of insomnia.[5] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.[6]
See also
[edit]References
[edit]- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
- ^ Tanaka E, Terada M, Misawa S, Wakasugi C (June 1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B: Biomedical Sciences and Applications. 682 (1): 173–8. doi:10.1016/0378-4347(96)00121-1. PMID 8832439.
- ^ "Benzodiazepine Names". non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2009-04-05.
- ^ Guan F, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of Analytical Toxicology. 23 (1): 54–61. doi:10.1093/jat/23.1.54. PMID 10022210.
- ^ Tan X, Uchida S, Matsuura M, Nishihara K, Kojima T (February 2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and Clinical Neurosciences. 57 (1): 97–104. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461. S2CID 20863635.
- ^ Sakai Y (October 1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems". Japanese Journal of Pharmacology. 33 (5): 1017–25. doi:10.1254/jjp.33.1017. PMID 6139494.
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