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Hyaline
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At left is a micrograph of spleen with hyaline deposition (pink material at top of image) in association with inflammation (hyaloserositis), using H&E stain. At right is a micrograph of a kidney with arterial hyaline (hyaline arteriolosclerosis), using PAS stain.
A hyaline substance is one with a glassy appearance. The word is derived from Greek: ὑάλινος, romanized: hyálinos, lit. 'transparent', and ὕαλος, hýalos, 'crystal, glass'.[1][2]
Histopathology
[edit]Hyaline cartilage is named after its glassy appearance on fresh gross pathology.[3] On light microscopy of H&E stained slides, the extracellular matrix of hyaline cartilage looks homogeneously pink, and the term "hyaline" is used to describe similarly homogeneously pink material besides the cartilage. Hyaline material is usually acellular and proteinaceous. For example, arterial hyaline is seen in aging, high blood pressure, diabetes mellitus and in association with some drugs (e.g. calcineurin inhibitors). It is bright pink with PAS staining.
Ichthyology and entomology
[edit]
In ichthyology and entomology, hyaline denotes a colorless, transparent substance, such as unpigmented fins of fishes or clear insect wings.[4]
Botany
[edit]In botany, hyaline refers to thin and translucent plant parts, such as the margins of some sepals, bracts and leaves.
See also
[edit]- Hyaline arteriolosclerosis
- Hyaloid canal, which passes through the eye
- Hyalopilitic
- Hyaloserositis
- Infant respiratory distress syndrome, previously known as hyaline membrane disease
References
[edit]- ^ IMA Mycological Glossary: Hyaline.
- ^ Hyaline definition in Merriam Webster Dictionary
- ^ Adele, Knibbs (2003). "The Leeds Histology Guide". Retrieved 27 October 2018.
- ^ Resh, Vincent H. and R. T. Cardé, Eds. Encyclopedia of Insects, Elsevier 2003.
- Taber's Cyclopedic Medical Dictionary, 19th Edition. Donald Venes ed. 1997 F.A. Davis. Page 1008.
_histopatholgy.jpg){kind=small} | This article related to pathology is a stub. You can help Wikipedia by expanding it. |
Hyaline
View on Grokipediafrom Grokipedia
Hyaline refers to a translucent, glassy-appearing substance or structure in biology and medicine, derived from the Greek word hyalos, meaning glass.[1][2] It is characterized by its homogeneous, transparent matrix and is observed in various contexts, including hyaline cartilage in vertebrates, transparent structures in animals like fish and insects, translucent features in plants and fungi, and pathological changes in tissues.[1]
In medicine, hyaline cartilage is the most abundant type of cartilage in the human body, providing structural support and flexibility in joints, airways, and skeletal elements.[3][4] The term also describes pathological conditions, such as hyaline degeneration in tissues and hyaline membrane disease (now known as respiratory distress syndrome) in premature infants.[5][6]
Etymology and General Definition
Origin of the Term
The term "hyaline" originates from the ancient Greek adjective hyálinos (ὑάλινος), meaning "of glass" or "transparent," derived from the noun hýalos (ὕαλος), which denoted glass or a similar translucent material.[7][8] In classical Greek literature, hýalos referred to transparent, hard, and luminous substances, often associated with imported glass artifacts, and appears in philosophical and natural history texts.[9][10] The word entered Latin as hyalinus, preserving its connotation of glass-like clarity, and was borrowed into English in the mid-17th century, with the earliest recorded uses around 1660 describing transparent or glassy appearances in natural phenomena or substances.[11][7] Initial English applications, such as in translations of classical works, extended the term to bodily fluids or tissues exhibiting a clear, homogeneous quality, reflecting its root in optical transparency.[11] Over time, "hyaline" evolved from its classical and early modern literary contexts into a specialized scientific term by the 19th century, particularly in fields like anatomy and microscopy, where it described structures with a refractive, glass-like homogeneity.[2] This adoption built on the term's inherent association with translucency, facilitating its integration into precise observational descriptions in emerging disciplines.[12]Physical and Optical Properties
Hyaline substances exhibit a distinctive homogeneous and translucent appearance under light microscopy, often resembling glass due to their glassy, refractive quality. This structureless, acellular nature results in a smooth, non-granular texture that lacks visible pigmentation or cellular debris, making it appear pale and uniform.[12][13][14] In terms of composition, hyaline material is typically proteinaceous, comprising proteins such as collagen or glycoproteins that contribute to its cohesive, amorphous matrix without forming distinct fibers or inclusions. This protein-based framework imparts rigidity while maintaining flexibility in various biological contexts, devoid of significant lipid or carbohydrate granulation.[12][13] Optically, hyaline displays high transparency to visible light, allowing light to pass through with minimal scattering, which enhances its refractive index akin to that of glass. In histological staining, such as hematoxylin and eosin (H&E), it typically appears pink or eosinophilic because of its affinity for eosin dye and the absence of contrasting cellular or nuclear elements that would otherwise disrupt the uniform coloration.[12][14][13]Medical and Histological Uses
Hyaline Cartilage
Hyaline cartilage is the most abundant type of cartilage in the human body, characterized by its translucent, glassy appearance due to an acellular extracellular matrix rich in type II collagen fibers, proteoglycans such as aggrecan, and a high water content of 65-80% that provides hydration and resilience.[15][16] The matrix also includes chondroitin sulfate for elasticity and lacks blood vessels, nerves, or lymphatics, making it avascular and reliant on diffusion for nutrient supply.[15] Structurally, it consists of chondrocytes embedded in lacunae within the matrix, organized into zones in articular forms—superficial, middle, deep, and calcified—with collagen fibers oriented to resist shear and compressive forces.[16] This tissue is found at the articular surfaces of long bones in synovial joints, such as the knee, where it forms a 2-4 mm thick layer; in the costal cartilages connecting ribs to the sternum; in the nasal septum; lining the trachea and bronchi; and throughout the fetal skeleton as a temporary scaffold.[15][17] In developing bones, it comprises the epiphyseal growth plates, facilitating longitudinal growth.[17] Hyaline cartilage provides structural support and flexibility while enabling low-friction articulation in joints, transmitting mechanical loads with minimal wear due to its lubricated surface and ability to absorb compressive forces through proteoglycan hydration.[15][16] It resists compression effectively but permits bending and deformation, essential for respiratory tract flexibility and skeletal stability during movement.[15] Developmentally, hyaline cartilage arises from mesodermal mesenchyme during embryogenesis through chondrogenesis, where progenitor cells differentiate into chondroblasts that secrete aggrecan and type II collagen to form the matrix.[15][18] Growth occurs via appositional mechanisms, with new matrix added peripherally by chondroblasts from the perichondrium, and interstitially through chondrocyte proliferation within the tissue.[17] In endochondral ossification, it serves as a template for long bone formation, where chondrocytes hypertrophy, mineralize the surrounding matrix with type X collagen, and are replaced by bone through vascular invasion and osteoblast activity, leaving articular cartilage intact.[18][17]Hyaline in Pathology
In pathology, hyaline denotes the pathological accumulation of homogeneous, glassy, proteinaceous material within tissues, distinct from its normal glassy appearance in structures like cartilage. This material arises from mechanisms such as leakage of plasma proteins into the interstitium or vessel walls, often exacerbated by endothelial damage, or from cellular stress leading to the aggregation of insoluble proteins like fibrin, immunoglobulins, or glycoproteins.48991-4/fulltext)[12] Hyaline degeneration manifests as proteinaceous deposits in cellular or vascular components, frequently observed in aging tissues, hypertensive hyaline arteriosclerosis affecting small arteries and arterioles, diabetic nephropathy with glomerular and arteriolar involvement, and toxicity from drugs like calcineurin inhibitors in renal transplant recipients, where it contributes to chronic allograft nephropathy through subendothelial protein insudation.[19][20] Specific disease examples include hyaline membrane disease (also known as neonatal respiratory distress syndrome), characterized by eosinophilic protein-rich membranes lining alveolar ducts due to surfactant deficiency in premature infants; hyaline casts in urine, formed from Tamm-Horsfall mucoprotein in distal tubules and signifying renal parenchymal damage in conditions like acute kidney injury or chronic glomerulonephritis; and hyaloserositis, a serosal fibrosis with hyaline coating on organs such as the spleen or liver (appearing as an "icing sugar" surface), typically secondary to chronic peritoneal or pleural inflammation.[21][22][23] Diagnosis relies on histological features: hyaline appears as structureless, acellular, pink eosinophilic material on hematoxylin and eosin (H&E) staining, intensifies to bright magenta on periodic acid-Schiff (PAS) due to carbohydrate components in the glycoproteins, and reveals amorphous, electron-dense aggregates without organized structure on electron microscopy, aiding differentiation from amyloid or other deposits.[12][24][25]Biological Uses in Animals
Transparent Structures in Fish and Insects
In ichthyology, hyaline structures refer to transparent, unpigmented anatomical features in fish that contribute to camouflage and hydrodynamic performance in aquatic environments.[26] These features, such as transparent fins and scales in pelagic species, reduce visibility and aid in predator avoidance and efficient swimming. Hyaline areas in fish eyes, particularly the cornea, exemplify adaptive transparency for optical function. The fish cornea is a thin, avascular layer composed of collagen fibers arranged to maintain high light transmission, with refractive properties adapted to underwater conditions where it provides minimal focusing but maximal protection and clarity.[27] In species inhabiting clear waters, this structure prevents light loss, enabling precise vision for foraging and predator detection without compromising the eye's structural integrity. In entomology, hyaline wings are prominent in various insect orders, serving roles in camouflage, flight efficiency, and signaling. Moths such as Cephonodes hylas (coffee clearwing moth) possess hyaline wings that mimic the appearance of bees, deterring predators through Batesian mimicry. In bees (Apidae), hyaline wings lack heavy pigmentation, reducing weight and drag to optimize aerodynamic performance and enable sustained hovering and rapid maneuvers essential for pollination. These wings transmit ultraviolet light, which may aid in navigation or mate attraction in pollinators. Hyaline cuticles in insects arise from the absence of melanin deposition during sclerotization, resulting in colorless, light-transmissive exoskeletal regions that support adaptive functions. In dragonflies (Odonata), transparent wing bases facilitate motion camouflage by minimizing visual cues to prey, allowing predatory strikes from apparent stasis. Similarly, transparent cuticles in certain aquatic insect larvae, such as those of mayflies, enhance concealment in clear streams by permitting light passage without absorption, thereby reducing silhouette formation against illuminated backgrounds. This lack of melanin also promotes structural lightness, beneficial for energy-efficient locomotion in flying species.[28]Hyaline in Cellular and Developmental Biology
In cell biology, the hyaline cap forms at the leading edge of motile amoebae, such as Amoeba proteus, as a thickened region of the hyaline layer—a thin, clear ectoplasmic zone adjacent to the plasma membrane that excludes organelles.[29] This cap arises through actin polymerization at filament plus ends near the membrane, leading to sol-to-gel conversion that generates a gel-like structure essential for pseudopod extension. The process supports cytoplasmic streaming into the pseudopod, enabling forward propulsion via myosin II-mediated contraction and substratum attachment, thus facilitating overall cell migration.[29] In developmental biology, particularly embryology, the hyaline layer emerges in sea urchin eggs (Strongylocentrotus purpuratus) within 20 minutes post-insemination as an extracellular investment surrounding the embryo.[30] Composed primarily of the calcium-precipitable protein hyalin, along with contributions from vitelline membrane proteins, it derives from precursors localized on the unfertilized egg surface, as evidenced by radioiodination and gel electrophoresis studies.[30][31] This layer transforms from the vitelline envelope into the fertilization envelope, providing a protective barrier against polyspermy while maintaining transparency that allows direct observation of embryonic cleavage and early development.[30][32] These hyaline structures serve broader functions in supporting cell migration through pseudopod dynamics, facilitating embryonic cleavage by stabilizing the blastomeres, and forming physical barriers during fertilization.[29][30] In renal cells, hyaline droplets represent a normal physiological feature in proximal tubule epithelia of mature male rats, manifesting as swollen lysosomes containing reabsorbed filtered proteins—primarily alpha-2u-globulin—undergoing proteolysis for recycling into amino acids.[33] Similarly, transparent hyaline cytoplasm appears in oocytes and early embryos of model organisms like sea urchins and ascidians, characterized by clear, vacuolated ectoplasm that aids in visualizing developmental processes such as blastomere segregation.[32][34]Botanical and Mycological Uses
Hyaline Features in Plants
In botany, hyaline refers to thin, translucent, and colorless plant tissues or structures that appear glassy or pellucid, particularly under transmitted light, due to their lack of pigmentation and sparse cellular content. These features are prevalent in vegetative and reproductive parts, such as leaf margins, sepals, and bracts, where they contribute to the overall morphology without adding opacity.[35][36] Prominent examples include the hyaline ligules in grasses (Poaceae), which form a membranous, transparent flap at the junction of the leaf sheath and blade, aiding in species identification through variations in shape and texture. In the Asteraceae family, hyaline bracts—often the outer phyllaries of the involucre—are delicately thin and pellucid, surrounding the flower heads as seen in genera like Senecio. Succulents such as Haworthia truncata and Fenestraria aurantiaca feature hyaline leaf tips or "windows," which are translucent epidermal regions at the apex. Orchids (Orchidaceae) commonly exhibit hyaline margins on sepals, enhancing the flower's delicate appearance.[37][38][39] These hyaline features fulfill protective and physiological roles, such as shielding sensitive areas from environmental hazards; for instance, grass ligules block water, dust, and fungal spores from entering the leaf sheath, while Asteraceae bracts safeguard developing florets and achenes against predators and desiccation. In shaded or arid habitats, hyaline leaf tips in succulents enable light penetration and diffusion to subsurface photosynthetic tissues, optimizing energy capture without exposing the plant to excessive sun. This translucency also supports aesthetic functions in floral displays, indirectly aiding pollination by attracting insects to vibrant inner structures.[40][39] Under microscopic examination, hyaline tissues reveal cells with thin primary cell walls, sparse cytoplasm, and minimal or absent chloroplasts, which eliminates chlorophyll-based light absorption and imparts a clear, refractive quality akin to glass. This structure contrasts with opaque photosynthetic tissues, emphasizing hyaline regions' specialization for transmission rather than energy production.[41]Hyaline in Fungi
In mycology, the term hyaline describes fungal structures that lack pigmentation, appearing colorless, transparent, or glassy under microscopic examination, in contrast to dematiaceous fungi with brown or dark pigments in their hyphae or spores. This absence of color is a key morphological feature used to classify various fungal groups, particularly within the hyaline molds, which encompass a diverse array of filamentous fungi with nonpigmented septate hyphae.[42][43][44] Hyaline structures are prevalent in Ascomycota, where they include transparent conidia and spores; for instance, Penicillium species produce hyaline conidiophores and conidia that form brush-like arrangements, contributing to their identification in environmental and clinical samples. In yeasts, such as Candida albicans, hyaline pseudohyphae and blastoconidia form during dimorphic growth, appearing clear and refractive in wet mounts or stained preparations. These examples highlight how hyaline features facilitate asexual reproduction and dispersal in both molds and yeasts.[45][42][46] Identification of hyaline fungi relies heavily on microscopic taxonomy, where their colorless nature allows them to appear highly refractive or transparent against a background in lactophenol cotton blue mounts or Calcofluor white stains, distinguishing them from pigmented counterparts without the need for advanced molecular tools in initial assessments. This optical property is crucial for rapid differentiation in clinical mycology, as hyaline hyphae often exhibit uniform septation and acute-angle branching, aiding species-level classification within genera like Aspergillus or Fusarium.[42][44][47] Ecologically, hyaline fungi predominantly occupy saprophytic niches, breaking down organic matter in soil, decaying vegetation, and indoor environments worldwide, while also serving as opportunistic pathogens that infect immunocompromised hosts via inhalation or trauma. Their ubiquitous distribution underscores their role in nutrient cycling, with pathogenic species like Aspergillus fumigatus exploiting hyaline hyphae for tissue invasion in conditions such as neutropenia.[43][42][48]References
- https://en.wiktionary.org/wiki/hyaline