Lawrence Berkeley National Laboratory (LBNL, Berkeley Lab) is a federally funded research and development center in the hills of Berkeley, California, United States. Established in 1931 by the University of California (UC), the laboratory is sponsored by the United States Department of Energy and administered by the UC system. Ernest Lawrence, who won the Nobel prize for inventing the cyclotron, founded the lab and served as its director until his death in 1958. Located in the Berkeley Hills, the lab overlooks the campus of the University of California, Berkeley.

The mission of Berkeley Lab is to bring science solutions to the world. The research at Berkeley Lab has four main themes: discovery science, energy, earth systems, and the future of science. The Laboratory's 22 scientific divisions are organized within six areas of research: Computing Sciences, Physical Sciences, Earth and Environmental Sciences, Biosciences, Energy Sciences, and Energy Technologies. Lab founder Ernest Lawrence believed that scientific research is best done through teams of individuals with different fields of expertise, working together, and his laboratory still considers that a guiding principle today.

Berkeley Lab scientists have won fifteen Nobel prizes in physics and chemistry, and each one has a street named after them on the Lab campus. 23 Berkeley Lab employees were contributors to reports by the United Nations' Intergovernmental Panel on Climate Change, which shared the Nobel Peace Prize. Fifteen Lab scientists have also won the National Medal of Science, and two have won the National Medal of Technology and Innovation. 82 Berkeley Lab researchers have been elected to membership in the National Academy of Sciences or the National Academy of Engineering.

In 2022, Berkeley Lab had the greatest research publication impact of any single government laboratory in the world in physical sciences and chemistry, as measured by Nature Index. The only institutions with higher ranking were national government research agencies for China, France, and Italy which are network of research laboratories or smaller research units. Using the same metric, the Lab is the second-ranking laboratory in the area of earth and environmental sciences.

Much of Berkeley Lab's research impact is built on the capabilities of its unique research facilities. The laboratory manages five national scientific user facilities, which are part of the network of 28 such facilities operated by the DOE Office of Science. These facilities and the expertise of the scientists and engineers who operate them are made available to 14,000 researchers from universities, industry, and government laboratories.

Berkeley Lab operates five major National User Facilities for the DOE Office of Science:

Much of the research at Berkeley Lab is done by researchers from several disciplines and multiple institutions working together as a large team focused on shared scientific goals. Berkeley is either the lead partner or one of the leads in several research institutes and hubs, including the following:

Cyclotron Road is a fellowship program for technology innovators, supporting entrepreneurial scientists as they advance their own technology projects. The core support for the program comes from the Department of Energy's Office of Energy Efficiency and Renewable Energy, through the Lab-Embedded Entrepreneurship Program. Berkeley Lab manages the program in close partnership with Activate, a nonprofit organization established to scale the Cyclotron Road fellowship model to a greater number of innovators around the U.S. and the world. Cyclotron Road fellows receive two years of stipend, over $100,000 of research support, intensive mentorship and a startup curriculum, and access to the expertise and facilities of Berkeley Lab. Since members of the first cohort completed their fellowships in 2017, the 84 start-up companies founded by Cyclotron Road Fellows have raised over $2.5 billion in follow-on funding.