The Runaway Scrape was the evacuations by Texas residents fleeing the Mexican Army of Operations during the Texas Revolution, from the Battle of the Alamo through the decisive Battle of San Jacinto. The events took place mainly between September 1835 and April 1836. The ad interim government of the new Republic of Texas and much of the civilian population fled eastward ahead of the Mexican forces. The conflict arose after Antonio López de Santa Anna abrogated the 1824 Constitution of Mexico and established martial law in Coahuila y Tejas. The Texians resisted and declared their independence. It was Sam Houston's responsibility, as the appointed commander-in-chief of the Provisional Army of Texas (before such an army actually existed), to recruit and train a military force to defend the population against troops led by Santa Anna.

Residents on the Gulf Coast and at San Antonio de Béxar began evacuating in January upon learning of the Mexican army's troop movements into their area, an event that was ultimately replayed across Texas. During early skirmishes, some Texian soldiers surrendered, believing that they would become prisoners of war — but Santa Anna demanded their executions. The news of the Battle of the Alamo and the Goliad massacre instilled fear in the population and resulted in the mass exodus of the civilian population of Gonzales, where the opening battle of the Texian revolution had begun and where, only days before the fall of the Alamo, they had sent a militia to reinforce the defenders at the mission. The civilian refugees were accompanied by the newly forming provisional army, as Houston bought time to train soldiers and create a military structure that could oppose Santa Anna's greater forces. Houston's actions were viewed as cowardice by the ad interim government, as well as by some of his own troops. As he and the refugees from Gonzales escaped first to the Colorado River and then to the Brazos, evacuees from other areas trickled in and new militia groups arrived to join with Houston's force.

The towns of Gonzales, Beason’s Crossing (present day Columbus) and San Felipe de Austin were burned to keep them out of the hands of the Mexican army. Santa Anna was intent on executing members of the Republic's interim government, who fled from Washington-on-the-Brazos to Groce's Landing to Harrisburgh and New Washington. The government officials eventually escaped to Galveston Island, and Santa Anna burned the towns of Harrisburgh and New Washington when he failed to find them. Approximately 5,000 terrified residents of New Washington fled from the Mexican army. After a little over a month of training the troops, Houston reached a crossroads where he ordered some of them to escort the fleeing refugees farther east while he took the main army southeast to engage the Mexican army. The subsequent Battle of San Jacinto resulted in the surrender of Santa Anna and the signing of the Treaties of Velasco.

By October 9, 1835, General Cos had taken over San Antonio de Béxar. Stephen F. Austin sent an advance scout troop of 90 men under James Bowie and James Fannin to observe the Mexican forces. While taking refuge at Mission Concepción on October 28, they repelled an attack by 275 Mexicans under Domingo Ugartechea. Austin continued to send troops to Béxar. Bowie was ordered on November 26 to attack a Mexican supply train allegedly carrying a payroll. The resulting skirmish became known as the Grass Fight, after it was discovered that the only cargo was grass to feed the horses. When Austin was selected to join Branch T. Archer and William H. Wharton on a diplomatic mission to seek international recognition and support, Edward Burleson was named as commander. On December 5, James C. Neill began distracting Cos by firing artillery directly at the Alamo, while Benjamin Milam and Frank W. Johnson led several hundred volunteers in a surprise attack. The fighting at the siege of Béxar continued until December 9 when Cos sent word he wanted to surrender. Cos and his men were sent back to Mexico but later united with Santa Anna's forces.

Approximately 300 of the Texian garrison at Béxar departed on December 30 to join Johnson and James Grant on the Matamoros Expedition, in a planned attack to seize the port for its financial resources. Proponents of this campaign were hoping Mexican Federalists would oust Santa Anna and restore the 1824 constitution. When Sesma crossed the Rio Grande, residents of the Gulf Coast began fleeing the area in January 1836. On February 16, Santa Anna ordered General José de Urrea to secure the Gulf Coast. About 160 miles (260 km) north of Matamoros at San Patricio, Urrea's troops ambushed Johnson and members of the expedition on February 27 at the Battle of San Patricio. In the skirmish, 16 Texians were killed, 6 escaped, and 21 were taken prisoner. Urrea's troops then turned southwest by some 26 miles (42 km) to Agua Dulce Creek and on March 2 attacked a group of the expedition led by Grant, killing all but 11, six of whom were taken prisoner. Five of the men escaped the Battle of Agua Dulce and joined Fannin who wanted to increase the defense force at Goliad.

Neill was promoted to lieutenant colonel during his participation in the siege of Béxar, and 10 days later Houston placed him in charge of the Texian garrison in the city. In January residents had begun evacuating ahead of Santa Anna's approaching forces. Neill pleaded with Houston for replenishment of troops, supplies and weaponry. The departure of Texians who joined the Matamoros Expedition had left Neill with only about 100 men. At that point Houston viewed Béxar as a military liability and did not want Santa Anna's advancing army gaining control of any remaining soldiers or artillery. He dispatched Bowie with instructions to remove the artillery, have the defenders abandon the Alamo mission and destroy it. Upon his January 19 arrival and subsequent discussions with Neill, Bowie decided the mission was the right place to stop the Mexican army in its tracks. He stayed and began to help Neill prepare for the coming attack. Lieutenant Colonel William B. Travis arrived with reinforcements on February 3. When Neill was given leave to attend to family matters on February 11, Travis assumed command of the mission, and three days later he and Bowie agreed to a joint command. Santa Anna crossed the Rio Grande on February 16, and the Mexican army's assault on the Alamo began February 23. Captain Juan Seguín left the mission on February 25, carrying a letter from Travis to Fannin at Goliad requesting more reinforcements. Santa Anna extended an offer of amnesty to Tejanos inside the fortress; a non-combatant survivor, Enrique Esparza, said that most Tejanos left when Bowie advised them to take the offer. In response to Travis' February 24 letter To the People of Texas, 32 militia volunteers formed the Gonzales Ranging Company of Mounted Volunteers and arrived at the Alamo on February 29.

If you execute your enemies, it saves you the trouble of having to forgive them.

— General Antonio López de Santa Anna, February 1836