Saltram House is a grade I listed George II era house in Plympton, Devon, England. It was deemed by the architectural critic Nikolaus Pevsner to be "the most impressive country house in Devon". The house was designed by the architect Robert Adam, who altered and greatly expanded the original Tudor house on two occasions. The Saloon is considered one of Adam's finest interiors. Saltram is one of Britain's best-preserved examples of an early Georgian house, and retains much of its original décor, plasterwork and furnishings. It contains the Parker family's large collection of paintings, including several by Sir Joshua Reynolds (1723–1792), who was born and educated at Plympton, and was a friend of the Parker family.

The present building was commenced by John Parker (1703–1768) of nearby Boringdon Hall, Plympton, and of Court House, North Molton, both in Devon, together with his wife Catherine Poulett (1706–1758), a daughter of John Poulett, 1st Earl Poulett. It was completed by his son John Parker, 1st Baron Boringdon (1735–1788), whose son was John Parker, 1st Earl of Morley (1772–1840). The Parker family had risen to prominence in the mid-16th century as the bailiff of the manor of North Molton, Devon, under Baron Zouche of Haryngworth.

The Saltram Estate was transferred to the National Trust in lieu of death duties in 1957, and is open to the public.

The name Saltram derives itself from the salt that was harvested on the nearby estuary and the fact that a "ham", or homestead, was on the site before the Tudor period.^{[citation needed]}

The first recorded family to have owned the house is that of Mayhew (alias Mayes, Mayhowes, etc.) who were yeoman farmers in the 16th century. The family owned Saltram for about 50 years, their prosperity declining at the end of the century when they began to sell and lease parts of the estate. Their landholdings were considerable – for example, a lease granted by them in 1588 granted the right to farm in Saltram Wood "and all houses, quays and buildings adjoining or upon the same", and to have fishing rights at Laira Bridge Rock and Culverhole; to hold portions of a quay called Coldharbour; and to have the use of the Mayhowes' fishing nets.

The next family to own Saltram were the Baggs, who were probably responsible for turning the farmhouse into a mansion. Sir James Bagg, MP for Plymouth (1601–1611) and Mayor of Plymouth, purchased Saltram in about 1614. On his death the house passed to his son James II Bagg (died 1638), Deputy Governor of Plymouth and a vice-admiral closely allied to George Villiers, 1st Duke of Buckingham, a favourite of King James I. He is believed twice to have embezzled funds from the Crown, the first occasion having contributed to the failure of Buckingham's attack on Cádiz in 1625. For reasons unknown King Charles I twice defended him despite his seemingly obvious culpability. James II Bagg died in 1638 and was succeeded by his son George Bagg, when Saltram was described as comprising "One great mansion house, one stable, three gardens, two acres of orchard, eight acres of meadows" and eight acres more. Despite inheriting his father's role as Deputy Governor of Plymouth, George Bagg did not share his father's luck and, Bagg having chosen the Royalist side in the English Civil War, Saltram suffered at the hands of the Parliamentarian forces. Following the defeat of the Royalist cause, shortly after 1643 he was forced to compound (pay a fine) in the sum of £582 to secure his landholdings.

Despite having held on to Saltram through the Civil War, the Baggs lost Saltram in 1660, shortly before the Stuart Restoration, when the Commonwealth government transferred it to the former Parliamentarian captain Henry Hatsell in payment of a large debt owed by Bagg. However, after the Restoration of the Monarchy in 1660, Hatsell was stripped of the house and estate, which were granted to Sir George Carteret in settlement of a loan he had made to the King during the Civil War.

In 1712 George Parker of Boringdon Hall, about two miles north of Saltram, purchased the manor of Saltram, and created the Parker dynasty which reigned over Saltram until its days as a private estate were over.