Topolino (from the Italian name for Mickey Mouse) is an Italian digest-sized comic series featuring Disney comics. The series has had a long running history, first appearing in 1932 as a comics magazine. Since 2013, it has been published by Panini Comics.

In 1932 the editor Mario Nerbini decided to open a new weekly newspaper for kids, containing illustrated tales with Mickey Mouse. The first issue of Topolino was published on December 31, 1932: it contained Mickey's first Italian story drawn by Giove Toppi. In this story, Mickey Mouse was chased by an elephant. However, Nerbini had not correctly secured the publication rights, so when Emmanuel (Disney's representative in Italy) protested, Nerbini changed the title of the comic book with issue #3 into Topo Lino (Mouse Lino), replacing Mickey Mouse with Topo Lino, another mouse. When Nerbini bought the publication rights from Disney and King Features Syndicate, he changed the title back to Topolino with issue #5. Floyd Gottfredson's stories made their debut in Topolino #7 with a Sunday page featuring Mickey, his girlfriend Minnie Mouse, and Mickey's nephews Morty and Ferdie Fieldmouse. Topolino published mainly Mickey Mouse Sunday pages; the daily strips were published in the supplement to the newspaper.

Topolino had eight pages and also published non-Disney comic strips such as Tim Tyler's Luck (Cino e Franco). In 1935 Topolino published Bobo the Elephant, Mickey Mouse and the sacred jewel and Mickey Mouse and Pluto the racer. The same year Arnoldo Mondadori's publishing house Mondadori bought the newspaper; the first issue published by Mondadori was #137.

In 1937 Topolino and I tre porcellini, Mondadori's newspapers for kids, merged into Topolino: Grandi avventure ("Mickey Mouse: Great adventures"). The page count increased from eight to sixteen. The first page published a story in instalments by Floyd Gottfredson starring Mickey Mouse and his friends; the other pages published American stories such as Tim Tyler's Luck as well as Italian stories such as Saturno contro la Terra, a story by Federico Pedrocchi (also editor of Mondadori's comics) in which Rebo (the dictator of Saturn, who later appeared as Donald Duck's enemy in four Italian stories drawn by Luciano Bottaro) made his debut. December 1937 also saw the publication of a companion newspaper, Paperino e altre avventure (Donald Duck and Other Adventures), which ran for three years before being merged with Topolino in October 1940.

In 1938, Mussolini's fascist government forbade the publishing of American stories except Disney stories (his children liked Mickey Mouse, and delayed the ban as long as possible). Topolino continued to publish Mickey Mouse stories until February 3, 1942 (#477, containing the last episode of Mickey Mouse in love trouble) when they were forced by the fascist government to stop publishing Mickey's stories. For two years, Mickey Mouse was replaced by Tuffolino, a human character very similar to Mickey. Tuffolino made his debut in Tuffolino agente di pubblicità, a remake (starring non-Disney characters) of American story Mickey Mouse, super salesman (1941). Tuffolino and his friends (Mimma, Clara) very much resembled Mickey, Minnie and Clarabelle Cow. Tuffolino's stories were written by Pedrocchi and drawn by Pier Lorenzo De Vita. The newspaper had to cease all publications in December 1943 (#564).

In December 1945, Mondadori resumed publication of Topolino. Because of the fall of fascism in Italy, Mondadori could once again publish Mickey Mouse stories by Floyd Gottfredson. Topolino also began publishing Donald Duck stories by Carl Barks. Topolino #713 published the first episode of Topolino e il cobra bianco, written by Guido Martina and drawn by Angelo Bioletto [it]; this was the first long Italian story to be published in the newspaper. In 1949, Mario Gentilini [it], Topolino's director, decided to convert the newspaper into a pocket comic book containing only Disney stories. The last issue of Topolino (giornale) was #738; on April 10, 1949 the first issue of Topolino digest (libretto) format was released.

Topolino started as a monthly comic book, and the first issue was released on April 10, 1949: it had 100 pages and its price was 60 lire. The first issue contained the final part of Topolino e il cobra bianco, the first episode of Gottfredson's Mickey Mouse and the man of Tomorrow (the story where Eega Beeva makes its debut), a Carl Barks ten-pager where Gladstone Gander makes his second appearance (though it's the first story with the character to be published in Italy), the long story Pluto Saves the Ship, written by Barks, Jack Hannah and Nick George and drawn by an unidentified illustrator, the first episode of a long Barks story (The Old Castle's Secret, where Scrooge McDuck makes his second appearance), and many stories about minor characters like Br'er Rabbit, Li'l Bad Wolf, etc.

Mickey's Inferno (L'inferno di Topolino), written by Guido Martina and drawn by Angelo Bioletto, was the second Italian story to be published on Topolino (#7–12): a parodic retelling of Dante Alighieri's Inferno, the panels of the comic also have a poem, written using hendecasyllables in terza rima, describing what's happening in each scene. Mickey's Inferno was the first Italian Great Parody and the first Disney story featuring credits, albeit partially: in the first panel, under the title of the story, it is written "verseggiatura di G. Martina", meaning "verses by G. Martina"; however, Martina was only credited for the poem and not for also writing the story, while Bioletto's work was similarly uncredited. The third Italian story to be published was Topolino e i grilli atomici (literally Mickey Mouse and the atomic crickets, #13-16), written by Martina and drawn by Bioletto: for the latter, it was his third and last Disney work. However Topolino published mainly American stories by Carl Barks, Floyd Gottfredson, Paul Murry and others and in 1951 the periodical published only American stories.