CLIC6

CLIC6
Identifiers
Aliases	CLIC6, CLIC1L, chloride intracellular channel 6
External IDs	OMIM: 615321; MGI: 2146607; HomoloGene: 43154; GeneCards: CLIC6; OMA:CLIC6 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	34,718,227 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	92,338,131 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; bronchial epithelial cell; ; nasal epithelium; ; caput epididymis; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; mucosa of paranasal sinus; ; pancreatic epithelial cell; ; olfactory zone of nasal mucosa; ; pancreatic ductal cell;
	Top expressed in
	Epithelium of choroid plexus; ; epithelium of stomach; ; retinal pigment epithelium; ; olfactory epithelium; ; ciliary body; ; migratory enteric neural crest cell; ; epithelium of small intestine; ; yolk sac; ; left colon; ; efferent ductule;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated ion channel activity; glutathione transferase activity; chloride channel activity; D2 dopamine receptor binding; D3 dopamine receptor binding; D4 dopamine receptor binding;
Cellular component	integral component of membrane; plasma membrane; extracellular exosome; membrane; chloride channel complex; nucleus; cytoplasm;
Biological process	regulation of ion transmembrane transport; chloride transport; ion transport; glutathione metabolic process; chloride transmembrane transport; transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	54102
	209195
	ENSG00000159212
	ENSMUSG00000022949
	Q96NY7
	Q8BHB9
	NM_053277; NM_001317009
	NM_172469
	NP_001303938; NP_444507
	NP_766057
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.^[5]^[6]

The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.^[6]

Interactions

CLIC6 has been shown to interact with Dopamine receptor D3.^[7]

Function

CLIC6 has been shown to form chloride selective redox and pH regulated ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells. ^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159212 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022949 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, et al. (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–319. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
^ ^a ^b "Entrez Gene: CLIC6 chloride intracellular channel 6".
^ Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
^ Loyo-Celis V, Patel D, Sanghvi S, Kaur K, Ponnalagu D, Zheng Y, et al. (November 2023). "Biophysical characterization of chloride intracellular channel 6 (CLIC6)". The Journal of Biological Chemistry. 299 (11): 105349. doi:10.1016/j.jbc.2023.105349. PMC 10641671. PMID 37838179.{{cite journal}}: CS1 maint: article number as page number (link)

External links

CLIC6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CLIC6 genome location and CLIC6 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159212 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022949 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10830953-5] Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, et al. (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–319. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.

[entrez-6] "Entrez Gene: CLIC6 chloride intracellular channel 6".

[pmid14499480-7] Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.

[pmid137838179-8] Loyo-Celis V, Patel D, Sanghvi S, Kaur K, Ponnalagu D, Zheng Y, et al. (November 2023). "Biophysical characterization of chloride intracellular channel 6 (CLIC6)". The Journal of Biological Chemistry. 299 (11): 105349. doi:10.1016/j.jbc.2023.105349. PMC 10641671. PMID 37838179.{{cite journal}}: CS1 maint: article number as page number (link)

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CLIC6

CLIC6

CLIC6

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Hub overview

Root Wikipedia Article

CLIC6

Interactions

Function

See also

References

Further reading

External links