KCNT2

KCNT2
Identifiers
Aliases	KCNT2, KCa4.2, SLICK, SLO2.1, potassium sodium-activated channel subfamily T member 2, EIEE57, DEE57
External IDs	OMIM: 610044; MGI: 3036273; HomoloGene: 16121; GeneCards: KCNT2; OMA:KCNT2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	196,609,225 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	140,539,805 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; endothelial cell; ; cartilage tissue; ; Brodmann area 23; ; Brodmann area 46; ; middle temporal gyrus; ; germinal epithelium; ; Achilles tendon; ; visceral pleura; ; cardiac muscle tissue of right atrium;
	Top expressed in
	aortic valve; ; prefrontal cortex; ; vas deferens; ; primary motor cortex; ; ascending aorta; ; medial dorsal nucleus; ; lateral septal nucleus; ; cingulate gyrus; ; dentate gyrus; ; subdivision of hippocampus;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated potassium channel activity; ATP binding; nucleotide binding; potassium channel activity; calcium-activated potassium channel activity; intracellular sodium activated potassium channel activity; outward rectifier potassium channel activity; chloride-activated potassium channel activity;
Cellular component	voltage-gated potassium channel complex; integral component of membrane; plasma membrane; membrane;
Biological process	potassium ion transmembrane transport; potassium ion transport; ion transport; regulation of membrane potential; potassium ion export across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	343450
	240776
	ENSG00000162687
	ENSMUSG00000052726
	Q6UVM3
	n/a
	NM_001287819; NM_001287820; NM_198503
	NM_001081027
	NP_001274748; NP_001274749; NP_940905
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily T, member 2, also known as KCNT2 is a human gene that encodes the K_Na protein. KCNT2, also known as the Slick channel (sequence like an intermediate calcium channel) is an outwardly rectifying potassium channel activated by internal raises in sodium or chloride ions.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162687 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052726 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

Bhattacharjee A, Joiner WJ, Wu M, et al. (2003). "Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP". J. Neurosci. 23 (37): 11681–91. doi:10.1523/JNEUROSCI.23-37-11681.2003. PMC 6740956. PMID 14684870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Santi CM, Ferreira G, Yang B, et al. (2006). "Opposite regulation of Slick and Slack K+ channels by neuromodulators". J. Neurosci. 26 (19): 5059–68. doi:10.1523/JNEUROSCI.3372-05.2006. PMC 6674240. PMID 16687497.
Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162687 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052726 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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KCNT2

KCNT2

KCNT2

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KCNT2

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