KCNK6

KCNK6
Identifiers
Aliases	KCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6
External IDs	OMIM: 603939; MGI: 1891291; HomoloGene: 31266; GeneCards: KCNK6; OMA:KCNK6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,332,076 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,931,940 bp
RNA expression pattern
	Top expressed in
	decidua; ; ectocervix; ; monocyte; ; right coronary artery; ; ascending aorta; ; myometrium; ; mucosa of transverse colon; ; vagina; ; smooth muscle tissue; ; parotid gland;
	Top expressed in
	fossa; ; skin of abdomen; ; right lobe of liver; ; epithelium of stomach; ; Paneth cell; ; parotid gland; ; condyle; ; stroma of bone marrow; ; mesenteric lymph nodes; ; umbilical cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inward rectifier potassium channel activity; voltage-gated ion channel activity; potassium channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; plasma membrane; membrane; integral component of plasma membrane;
Biological process	regulation of resting membrane potential; potassium ion transport; regulation of ion transmembrane transport; cardiac conduction; ion transport; negative regulation of systemic arterial blood pressure; potassium ion transmembrane transport; regulation of systemic arterial blood pressure; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	9424
	52150
	ENSG00000099337
	ENSMUSG00000046410
	Q9Y257
	n/a
	NM_004823
	NM_001033525
	NP_004814; NP_004814.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 6 is a protein encoded by the KCNK6 gene in humans.^[5]^[6]^[7]^[8]

This gene encodes K_2P6.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid and inhibited by internal acidification and volatile anaesthetics.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099337 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046410 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887–92. doi:10.1074/jbc.274.12.7887. PMID 10075682.
^ Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (3–4): 190–1. doi:10.1159/000015255. PMID 10393428. S2CID 84538070.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".

External links

KCNK6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099337 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046410 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10075682-5] Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887–92. doi:10.1074/jbc.274.12.7887. PMID 10075682.

[pmid10393428-6] Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (3–4): 190–1. doi:10.1159/000015255. PMID 10393428. S2CID 84538070.

[pmid16382106-7] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-8] "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".

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KCNK6

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KCNK6

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