CMKLR2

CMKLR2
Identifiers
Aliases	CMKLR2, G protein-coupled receptor 1, chemerin chemokine-like receptor 2, GPR1
External IDs	OMIM: 600239; MGI: 2385324; HomoloGene: 21094; GeneCards: CMKLR2; OMA:CMKLR2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	206,218,047 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	63,253,702 bp
RNA expression pattern
	Top expressed in
	placenta; ; stromal cell of endometrium; ; testicle; ; mucosa of esophagus; ; skin of leg; ; right adrenal cortex; ; ventricular zone; ; left adrenal gland; ; gallbladder; ; left adrenal cortex;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; placenta; ; urethra; ; female urethra; ; decidua; ; male urethra; ; epithelium of urethra; ; epithelium of male urethra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neuropeptide binding; signal transducer activity; protein binding; G protein-coupled receptor activity; peptide binding;
Cellular component	membrane; integral component of membrane; integral component of plasma membrane; neuron projection; plasma membrane; intracellular membrane-bounded organelle; nucleoplasm;
Biological process	chemical synaptic transmission; neuropeptide signaling pathway; G protein-coupled receptor signaling pathway; signal transduction; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
	Sources:Amigo / QuickGO
Orthologs
	2825
	241070
	ENSG00000183671; ENSG00000283448
	ENSMUSG00000046856
	P46091
	Q8K087
NM_001098199; NM_001261452; NM_001261453; NM_001261454; NM_001261455;
	NM_005279; NM_001389445
	NM_146250; NM_001357045
NP_001091669; NP_001248381; NP_001248382; NP_001248383; NP_001248384;
	NP_005270
	NP_666362; NP_001343974
	Wikidata
View/Edit Human	View/Edit Mouse

Chemerin-like receptor 2, is a protein that in humans is encoded by the CMKLR2 gene.^[5]^[6]

CMKLR2 is a rhodopsin-like receptor and therefore a member of the G protein-coupled receptor family of transmembrane receptors. It functions as a receptor for chemerin.^[7] Other receptors for chemerin include CMKLR1 and CCRL2.

References

^ ^a ^b ^c ENSG00000283448 GRCh38: Ensembl release 89: ENSG00000183671, ENSG00000283448 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046856 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "CMKLR2 chemerin chemokine-like receptor 2 [ Homo sapiens (human) ]".
^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (October 1994). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
^ Barnea G, Strapps W, Herrada G, Berman Y, Ong J, Kloss B, Axel R, Lee KJ (January 2008). "The genetic design of signaling cascades to record receptor activation". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 64–9. doi:10.1073/pnas.0710487105. PMC 2224232. PMID 18165312.

Shimizu N, Soda Y, Kanbe K, et al. (1999). "An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication of Human Immunodeficiency Virus Types 1 and 2 in Brain-Derived Cells". J. Virol. 73 (6): 5231–9. doi:10.1128/JVI.73.6.5231-5239.1999. PMC 112576. PMID 10233994.
Tokizawa S, Shimizu N, Hui-Yu L, et al. (2000). "Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor". Kidney Int. 58 (2): 607–17. doi:10.1046/j.1523-1755.2000.00207.x. PMID 10916084.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kang MK, Kameta A, Shin KH, et al. (2003). "Senescence-associated genes in normal human oral keratinocytes". Exp. Cell Res. 287 (2): 272–81. doi:10.1016/S0014-4827(03)00061-2. PMID 12837283.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Jinno-Oue A, Shimizu N, Soda Y, et al. (2005). "The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1". J. Biol. Chem. 280 (35): 30924–34. doi:10.1074/jbc.M500195200. PMID 15919664.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] ENSG00000283448 GRCh38: Ensembl release 89: ENSG00000183671, ENSG00000283448 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046856 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "CMKLR2 chemerin chemokine-like receptor 2 [ Homo sapiens (human) ]".

[pmid7851889-6] Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (October 1994). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.

[pmid18165312-7] Barnea G, Strapps W, Herrada G, Berman Y, Ong J, Kloss B, Axel R, Lee KJ (January 2008). "The genetic design of signaling cascades to record receptor activation". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 64–9. doi:10.1073/pnas.0710487105. PMC 2224232. PMID 18165312.

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