Tarascon (French pronunciation: [taʁaskɔ̃]; Occitan: Tarascon), sometimes referred to as Tarascon-sur-Rhône, is a commune situated at the extreme west of the Bouches-du-Rhône department of France in the Provence-Alpes-Côte d'Azur region. Inhabitants are referred to as Tarasconnais or Tarasconnaises. The patron saint of the city is Martha of Bethany, whose motto is "Concordia Felix".

Tarascon is located 23 km (14 mi) south of Avignon and 20 km (12 mi) north of Arles, on the left (east) bank of the river Rhône. On the other side is the similarly sized town of Beaucaire in the département of Gard, région of Occitania. Directly opposite each other and connected by several bridges, Beaucaire and Tarascon effectively constitute one town, with about 30,000 inhabitants. An irrigation canal of 18,00 km length rejoins the Rhone near Tarascon.

Shards dating from the Late Bronze Age have been found in a shelter at a place called the Lèque, confirming the existence of human settlement in the Alpilles since prehistoric times. Settlement spread in the early Iron Age. At Tarascon, the sites sit alongside the Rhone, near the church of Sainte-Marthe.

In the second part of the first Iron Age (7th–6th centuries BC), the population shifted from a nomadic lifestyle to a sedentary one and began to construct extensive buildings. Trade intensified with the Eastern Mediterranean, with the people of the area likely trading grain for luxury goods.

Located along the Rhone, at the crossroads between Avignon, the Camargue and the Luberon, Tarascon is still associated with fairy tales and legends dating back to prehistory. According to tradition, Martha of Bethany, who came from Judea, landed at Tarascon c. AD 48 where an amphibious dragon or tarasque was destroying the river traffic. She tamed the beast only for it to be butchered by the townspeople. Many pilgrims visit the Royal College of Sainte-Marthe, built in her honor near the castle of King René. This sanctuary, the main monument of the city, contains the relics and the tomb of St. Martha in the crypt which was built on the exact location of her house.

Rostagnetus of Tharascone, knight, was provost of Nice, Alderman of Tarascon (1322, 1325) and son of former co-lords of the city in the 12th century. In 1366–67, Guillam de Sault ruled Tarascon. He received an annual salary of 90 florins. The death of Queen Joanna I reopened a succession crisis at the head of the County of Provence, the cities of the Aix Union (1382–1387) supporting Charles de Duras against Louis I of Anjou . Tarascon hesitated before joining the Union of Aix, the community deciding in 1383, without committing itself very firmly. When Louis I died, Tarascon was also one of the first cities to receive Jacques Reillanne, Ambassador of his widow Marie de Blois, regent of Louis II of Anjou, in the summer of 1385. He successfully persuaded them to switch sides and join the Angevin Kings of Anjou. The castle is well preserved. The work of construction began in 1400 under Louis II of Anjou and completed in 1449 by his son, King René, led by Guillaume Crespin, captain of the castle, and his lieutenant, Regnault Serocourt, its close relative . With an impressive defensive system, the building also houses a princely residence.

The town was damaged by Allied bombings from June to August 1944, during World War II. The bombings, targeting the bridges across the Rhone in an attempt to hamper the German retreat, destroyed parts of the old town. The first bombing took place on 25 June 1944. On 16 August 1944 the tip of the church tower of Église Sainte-Marthe was destroyed.

Église collégiale Ste Marthe (St Martha's Collegiate Church) is where, according to a local tradition, the biblical figure Martha is buried. The church was built half-Romanesque in the 12th century and half-Gothic in the 14th century. The crypt dates from the 3rd century.