Warframe is a free-to-play action role-playing third-person shooter multiplayer online game developed and published by Digital Extremes. First released for Windows in March 2013, it was later ported to PlayStation 4 in November 2013, Xbox One in September 2014, Nintendo Switch in November 2018, PlayStation 5 in November 2020, Xbox Series X/S in April 2021, and iOS in February 2024. Support for cross-platform play was released in 2022. Cross-platform save began in December 2023, rolling out in waves to different groups of players before becoming fully available to all players in January 2024. A port for Android has now been developed.

In Warframe, players control members of the Tenno, a caste of ancient warriors who have awoken from centuries of suspended animation far into Earth's future to find themselves at war with different factions in the Origin System. The Tenno use their powered Warframes, along with a variety of weapons and abilities, to complete missions. While many of the game's missions use procedurally generated levels, it also includes large open world areas similar to other massively multiplayer online games, as well as some story-specific missions with fixed level design. The game includes elements of shooting and melee games, parkour, and role-playing to allow players to advance their Tenno with improved gear. The game features both player versus environment and player versus player elements. It is supported by microtransactions, allowing players to purchase in-game items with money, while also offering the option to earn them at no cost through grinding.

The concept for Warframe originated in 2000 when Digital Extremes began work on a new game titled Dark Sector. At the time, the company had been successful in supporting other developers and publishers but wanted to develop its own game in-house. Dark Sector suffered several delays and was eventually released in 2008, incorporating some of the initial framework but differing significantly from the original plan. By 2012, in the wake of the success of free-to-play games, the developers took their earlier Dark Sector ideas and art assets and incorporated them into a new project, their self-published Warframe.

Initially, the growth of Warframe was slow, hindered by moderate critical reviews and low player counts. However, since its release, the game has experienced significant growth. It is one of Digital Extremes' most successful titles, reaching nearly 50 million registered players by 2019.

Warframe is scheduled to be released on Nintendo Switch 2.

Warframe is set in a far future version of the Solar System, now known as the Origin System. At the start of the game players are given control of members of the Tenno, warriors who have awoken from a millennia-long cryosleep on Earth by the Lotus, who acts as a guide for the player. They join an interplanetary war between the Grineer, a violent war-driven matriarchal race of militarized human clones; the Corpus, a mega-corporation centered around a religion dedicated to profit; the Infested, disfigured victims of the Technocyte virus; the Sentients, a race of self-replicating machines made by a long-dead transhuman race known as the Orokin; and the Corrupted, brainwashed variants of the previous three faction's units defending ancient Orokin towers.

All of the factions encountered in the game, including the Tenno, were created by or are splinter groups of the old Orokin Empire, which the Tenno learns was an ancient fallen civilization and former reigning power in the Origin System. Although virtually all of them are long dead by the time of the Tenno's awakening, their lingering presence can still be felt throughout the Origin System. Before their fall, the Orokin had realized the Origin System was becoming dangerously depleted of resources, and their solution to keep their empire alive was to colonize new star systems. The Orokin sent out colony ships through the Void, a trans-dimensional space that enabled fast travel between stellar systems. They had also sent out the Sentients beforehand, to arrive in the Tau system first, and terraform it, so the colonists would arrive to garden worlds, capable of supporting human life. None of these residential ships returned, and those they had loaded with Sentients returned with the Sentients now deciding to wipe out the Orokin, leading to the Old War, the creation of the Tenno, and finally, the collapse of the Empire.

In the game's "The Second Dream" quest, which was introduced in December 2015, the player discovers that the Lotus is a Sentient known as Natah, rebelling against the Sentients to protect the Tenno, desiring to have surrogate children after losing her ability to procreate. The Lotus' father, Hunhow, sends a vengeful assassin called the Stalker to Lua (the remains of Earth's Moon), which the Lotus had hidden in the Void, to find its secret. The Lotus dispatches the Tenno there to stop the Stalker, arriving too late as the Stalker unveils the entity that the Lotus had protected: a human child known as the Operator, who is the real Tenno controlling the Warframes through the course of the game. The Operator is one of several tenno children that survived the passage of the Zariman Ten 0 colony ship through the Void; the adults have all gone mad from its travel. When the ship returned to the Orokin Empire, the children had all been put to sleep for thousands of years, outlasting the fall of the Empire, to be found by the Lotus and becoming the Tenno (Tenno short for the "Ten Zero" of the ship's name). The power of the Void gave these children the power of Transference. An ability that allows them to control Warframes. From this point forward, the player can then engage in missions both as the Warframe and the Operator.