Manoppello (Abruzzese: Manuppèlle) is a comune in Abruzzo, in the province of Pescara, south-eastern Italy.

It is famous for having a church which contains an image on a thin byssus veil, a sudarium, known as the Holy Face of Manoppello and which has been reputed to be identical to the Veil of Veronica.

Other sights include is the Romanesque abbey of Santa Maria Arabona.