Nonpoint source (NPS) pollution refers to diffuse contamination (or pollution) of water or air that does not originate from a single discrete source. This type of pollution is often the cumulative effect of small amounts of contaminants gathered from a large area. It is in contrast to point source pollution which results from a single source. Nonpoint source pollution generally results from land runoff, precipitation, atmospheric deposition, drainage, seepage, or hydrological modification (rainfall and snowmelt) where tracing pollution back to a single source is difficult. Nonpoint source water pollution affects a water body from sources such as polluted runoff from agricultural areas draining into a river, or wind-borne debris blowing out to sea. Nonpoint source air pollution affects air quality, from sources such as smokestacks or car tailpipes. Although these pollutants have originated from a point source, the long-range transport ability and multiple sources of the pollutant make it a nonpoint source of pollution; if the discharges were to occur to a body of water or into the atmosphere at a single location, the pollution would be single-point.

Nonpoint source water pollution may derive from many different sources with no specific solutions or changes to rectify the problem, making it difficult to regulate. Nonpoint source water pollution is difficult to control because it comes from the everyday activities of many different people, such as lawn fertilization, applying pesticides, road construction or building construction. Controlling nonpoint source pollution requires improving the management of urban and suburban areas, agricultural operations, forestry operations and marinas.

Types of nonpoint source water pollution include sediment, nutrients, toxic contaminants and chemicals and pathogens. Principal sources of nonpoint source water pollution include: urban and suburban areas, agricultural operations, atmospheric inputs, highway runoff, forestry and mining operations, marinas and boating activities. In urban areas, contaminated storm water washed off of parking lots, roads and highways, called urban runoff, is usually included under the category of non-point sources (it can become a point source if it is channeled into storm drain systems and discharged through pipes to local surface waters). In agriculture, the leaching out of nitrogen compounds from fertilized agricultural lands is a nonpoint source water pollution. Nutrient runoff in storm water from "sheet flow" over an agricultural field or a forest are also examples of non-point source pollution.

Sediment (loose soil) includes silt (fine particles) and suspended solids (larger particles). Sediment may enter surface waters from eroding stream banks, and from surface runoff due to improper plant cover on urban and rural land. Sediment creates turbidity (cloudiness) in water bodies, reducing the amount of light reaching lower depths, which can inhibit growth of submerged aquatic plants and consequently affect species which are dependent on them, such as fish and shellfish. With an increased sediment load into a body of water, the oxygen can also be depleted or reduced to a level that is harmful to the species living in that area. High turbidity levels also inhibit drinking water purification systems. Sediments are also transported into the water column due to waves and wind. When sediments are eroded at a continuous rate, they will stay in the water column and the turbidity level will increase.

Sedimentation is a process by which sediment is transported to a body of water. The sediment will then be deposited into the water system or stay in the water column. When there are high rates of sedimentation, flooding can occur due to a build-up of too much sediment. When flooding occurs, waterfront properties can be damaged further by high amounts of sediment being present.

Sediment can also be discharged from multiple different sources. Sources include construction sites (although these are point sources, which can be managed with erosion controls and sediment controls), agricultural fields, stream banks, and highly disturbed areas.

Nutrients mainly refers to inorganic matter from runoff, landfills, livestock operations and crop lands. The two primary nutrients of concern are phosphorus and nitrogen.

Phosphorus is a nutrient that occurs in many forms that are bioavailable. It is notoriously over-abundant in human sewage sludge. It is a main ingredient in many fertilizers used for agriculture as well as on residential and commercial properties and may become a limiting nutrient in freshwater systems and some estuaries. Phosphorus is most often transported to water bodies via soil erosion because many forms of phosphorus tend to be adsorbed on to soil particles. Excess amounts of phosphorus in aquatic systems (particularly freshwater lakes, reservoirs, and ponds) leads to proliferation of microscopic algae called phytoplankton. The increase of organic matter supply due to the excessive growth of the phytoplankton is called eutrophication. A common symptom of eutrophication is algae blooms that can produce unsightly surface scums, shade out beneficial types of plants, produce taste-and-odor-causing compounds, and poison the water due to toxins produced by the algae. These toxins are a particular problem in systems used for drinking water because some toxins can cause human illness and removal of the toxins is difficult and expensive. Bacterial decomposition of algal blooms consumes dissolved oxygen in the water, generating hypoxia with detrimental consequences for fish and aquatic invertebrates.