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Piperidinylindole
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Piperidinylindoles are a group of chemical compounds related to the tryptamines. Examples of these compounds include the simple piperidinylindoles SN-22 and BRL-54443, the triptans naratriptan and LY-334370, and the more structurally complex antipsychotic sertindole. The piperidinylindoles are similar to cyclized tryptamines like the tetrahydropyridinylindoles RS134-49 and RU-28253, but are not technically tryptamines themselves. Piperidinylindoles are known to act as serotonin receptor modulators.[1][2][3]
Chemical structures of selected piperidinylindoles
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See also
[edit]References
[edit]- ^ Taylor EW, Nikam SS, Lambert G, Martin AR, Nelson DL (July 1988). "Molecular determinants for recognition of RU 24969 analogs at central 5-hydroxytryptamine recognition sites: use of a bilinear function and substituent volumes to describe steric fit". Mol Pharmacol. 34 (1): 42–53. PMID 3393140.
- ^ Kitson SL (2007). "5-hydroxytryptamine (5-HT) receptor ligands". Curr Pharm Des. 13 (25): 2621–37. doi:10.2174/138161207781663000. PMID 17897004.
- ^ Vries, Peter De; Villalón, Carlos M; Saxena, Pramod R (1999). "Pharmacology of triptans". Emerging Drugs. 4 (1): 107–125. doi:10.1517/14728214.4.1.107. ISSN 1361-9195. Retrieved 29 July 2025.
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