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Rotationplasty, commonly known as a Van Nes rotation or Borggreve rotation, is a type of autograft wherein a portion of a limb is removed, while the remaining limb below the involved portion is rotated and reattached. This procedure is used when a portion of an extremity is injured, or affected by a disease such as cancer.[1]

The procedure is most commonly used to transfer the ankle joint to the knee joint following removal of a distal femoral bone tumor, such as osteosarcoma. The limb is rotated because the ankle flexes in the opposite direction compared to the knee. The benefit to the patient is that they have a functioning knee joint to which a prosthetic can be fitted, providing them with better mobility.

History

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Rotationplasty was first performed by Joseph Borggreve in 1927.[2] He performed the procedure on a 12-year-old boy who suffered from tuberculosis. However, the procedure was not well known until 1950, when Dutch orthopedist Cornelis Pieter van Nes (1897–1972) reported the results of rotationplasty procedures.[3] He became well known for establishing the procedure. Since then, many surgeons have performed modified versions of rotationplasty and have had great success.[citation needed]

Originally, rotationplasty was performed to treat infections and tumors around the knee. It was also a common treatment for osteosarcoma.[4] While it is still being used to treat their complications, rotationplasty is also used to treat growing children who have been diagnosed with tumors around the knee.[5] Rotationplasty is also performed on children with congenital femoral deficiencies. Those deficiencies cause "unstable hip joint[s] and a femur that is 50% shorter than the contralateral, normal femur."[6] This procedure gives rotationplasty patients the ability to have the use of both feet and allows them to continue living an active lifestyle.[citation needed]

Procedure

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In the actual procedure, the bone affected by the tumor, as well as a small part of the healthy femoral and occasionally tibia bone, is removed. A portion of the leg removed; the ankle joint is then turned 180 degrees and is reattached to the thigh. They are held together by plates and screws until they have healed naturally. The surgery can take anywhere from 6 to 10 hours, with a day or two in intensive care.[7] The leg is kept in a cast for 6 to 12 weeks. After the leg has sufficiently healed, the leg can be fitted for a prosthetic.[8]

Advantages and disadvantages

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Advantages

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Rotationplasty allows the use of the knee joint, whereas amputation would result in loss of that joint. Therefore, it provides a better attachment point and range of motion for a prosthetic limb. As a result, children who have had rotationplasty can play sports, run, climb, and do more than would be possible with a jointless prosthetic. After the procedure, the leg is durable; patients do not typically have to undergo additional surgeries.[5]

Disadvantages

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Rotationplasty can result in poor circulation throughout the leg, infection, nerve injuries, bone healing complications, and fracture of the leg.[9]

Quality of life

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A 2002 study measured life contentment and quality of life in 22 patients who had been recipients of the rotationplasty procedure at least 10 years before. They found that those patients that were younger when the procedure was performed were happier with their lives. It was also found that 8 of the 22 had to have a total of 21 surgical revisions performed in the 10 years. In comparison to the general population, the patients had a higher percentage of quality of life, 83% compared to 75%. Overall, the patients were more content with different aspects of their lives than the general population.[10]

References

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Rotationplasty

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Rotationplasty is a specialized orthopedic surgical procedure that involves the resection of a diseased section of the lower extremity, typically the knee joint and surrounding bone, followed by a 180-degree rotation of the distal leg (shin, ankle, and foot) and its reattachment to the proximal thigh, effectively transforming the ankle into a functional knee joint for prosthetic use.[1] This limb-salvage technique is most commonly performed as an alternative to above-knee amputation in pediatric patients with bone sarcomas, such as osteosarcoma or Ewing sarcoma, located near the knee, allowing preservation of the patient's own limb tissues while enabling high levels of mobility and activity.[2][3] The procedure was first described in 1930 by German surgeon Joseph Borggreve for treating femoral deficiency associated with tuberculosis of the knee, and it was later adapted by C.P. Van Nes in 1950 for congenital proximal femoral focal deficiency.[3] Its application to oncologic resections began in 1981, popularized by Salzer et al. for skeletally immature patients requiring knee or proximal femur resection due to malignant tumors.[3] Today, rotationplasty is indicated not only for bone cancers but also for certain congenital deformities, traumatic injuries, or severe infections affecting the lower limb, provided the sciatic nerve and distal leg neurovascular structures remain intact and functional.[1][2] It is particularly advantageous in growing children under age 12, as it accommodates natural bone lengthening without the need for frequent reconstructive revisions.[2] During surgery, performed under general anesthesia and lasting 4 to 10 hours, the tumor-affected bone segment—including the distal femur, knee joint, and proximal tibia—is excised with margins of healthy tissue to ensure oncologic clearance, after which the lower leg is rotated posteriorly and fixed to the remaining femur using plates, screws, or other osteosynthesis methods, often involving tendon transfers for stability.[1][3] Postoperatively, patients typically spend 1 to 2 days in intensive care followed by a hospital stay of several days, with bone healing requiring 3 to 6 months; intensive physical therapy is essential to adapt the ankle's flexion as the new knee motion and to fit a custom prosthesis that accommodates the rotated foot.[1][2] Key benefits include superior functional outcomes compared to traditional amputation or endoprosthetic reconstruction, such as reduced phantom limb pain, avoidance of prosthetic joint failures, and the ability to participate in sports—studies report that up to 85% of patients engage in athletic activities without significant psychosocial impairment.[3] Risks, however, include infection, nerve or vascular injury, delayed union of the bone, and compartment syndrome, necessitating surgery at specialized centers experienced in pediatric oncology and limb reconstruction.[1][2] With proper rehabilitation, most patients achieve independent ambulation within 3 to 6 months and resume normal activities by 6 to 12 months, highlighting rotationplasty's role as a durable, biologic solution for complex lower limb salvage.[1]

Overview and Indications

Definition and Purpose

Rotationplasty is an autologous reconstructive surgery that involves resecting a portion of the lower limb around the knee, typically including the distal femur, knee joint, and proximal tibia, followed by a 180-degree external rotation of the remaining lower leg segment and its reattachment to the proximal femur, thereby transforming the ankle joint into a functional neo-knee joint suitable for prosthetic fitting.[1][4][5][3] The primary purpose of rotationplasty is to achieve limb salvage in scenarios where traditional reconstruction is not feasible, preserving native proprioception and joint function to enable enhanced mobility through a below-knee equivalent prosthesis, which offers greater durability and energy efficiency compared to above-knee alternatives.[1][4][3] This approach avoids complications associated with endoprosthetic replacements, such as loosening or infection, while maintaining the patient's own tissues for long-term functionality.[3] Anatomically, the procedure repositions the foot posteriorly through the rotation, allowing the ankle's dorsiflexion and plantarflexion to simulate knee flexion and extension, with the tibia affixed to the femur using minimal internal fixation to bridge the resection gap and support prosthetic attachment at the neo-knee.[1][5][4] It is most commonly applied in lower limb reconstruction for pediatric patients, particularly those requiring extensive resection around the knee to address malignant bone tumors.[4][5][3]

Patient Selection and Indications

Rotationplasty is primarily indicated for the treatment of malignant bone tumors such as osteosarcoma or Ewing sarcoma located in the distal femur or proximal tibia, where limb salvage is feasible but traditional reconstruction may not be optimal.[1][6] It is also recommended for severe congenital femoral deficiency, particularly in cases involving significant limb length discrepancy or functional impairment.[1][7] Additionally, the procedure serves as a salvage option for traumatic injuries, chronic osteoarticular infections, or non-unions that have not responded to conservative treatments or prior interventions.[7][6] The procedure is most commonly performed in children and adolescents, typically under 18 years of age, due to their skeletal immaturity, which allows for continued growth and better adaptation to prosthetic fitting post-surgery.[1][7] In pediatric populations, girls up to approximately age 12 and boys up to age 14 are considered ideal candidates, as their growth potential minimizes the need for repeated revisions compared to endoprosthetic replacements.[8] While less frequent, rotationplasty can be suitable for adults in select cases, such as recurrent tumors or failed limb salvages, provided they demonstrate adequate physical and psychological resilience.[7][6] Patient selection requires a multidisciplinary evaluation focusing on anatomical and functional prerequisites, including preserved sciatic nerve integrity, intact popliteal vessels, and full range of motion in the hip and ankle joints to ensure viable rotation and prosthetic use.[1][7] Psychological readiness of the patient and family is essential, given the cosmetic alterations and long-term prosthetic management involved, with preoperative imaging such as CT scans confirming tumor resectability without nerve or vascular infiltration.[7][9] Contraindications include inadequate vascular status, poor skin condition, high infection risk, or pre-existing non-ambulatory status, which may necessitate amputation instead.[7][6][9] Compared to alternatives like above-knee amputation or endoprosthetic reconstruction, rotationplasty is preferred in very young patients or when prostheses have failed due to infection or loosening, as it offers superior knee-like motion, improved gait energy efficiency, and avoidance of phantom limb pain while reducing the frequency of revisions.[7][6] This approach is particularly advantageous for maintaining active lifestyles in skeletally immature individuals with femoral sarcomas, where growth-related complications from other methods are a concern.[10][7]

Historical Development

Early Procedures

The origins of rotationplasty trace back to the early 20th century, amid efforts in orthopedic surgery to preserve limb function in the face of severe infections and deformities. The procedure was first performed in 1927 by German surgeon Joseph Borggreve on a 12-year-old boy suffering from tuberculous coxitis, a hip infection that had led to a fused knee and significant limb shortening.[11] Borggreve's motivation was to improve the patient's gait and overall mobility by salvaging the limb rather than resorting to amputation, reflecting the era's growing emphasis on reconstructive techniques in limb salvage.[12] Borggreve detailed his technique in a 1930 publication, describing a 180-degree rotation of the lower leg to reposition the ankle, which was then fused to the greater trochanter of the femur to create a functional neo-joint.[13] This innovative approach aimed to convert the ankle into a knee-like hinge, allowing for better prosthetic adaptation and weight-bearing. However, the initial case achieved only limited success, as the patient experienced persistent pain and instability, underscoring the challenges of implementing such a complex surgery without modern supportive measures.[3] Prior to the 1950s, rotationplasty remained a rare intervention, primarily applied in isolated cases of severe lower limb infections such as tuberculosis, where traditional treatments like arthrodesis or excision failed to restore adequate function.[14] These early applications were rooted in the broader orthopedic advancements of the time, including pioneering work on joint replacements and deformity corrections during the interwar period, though adoption was hampered by the procedure's technical demands.[15] High complication rates plagued these foundational procedures, including infection, nonunion, and vascular issues, exacerbated by inadequate anesthesia, the absence of effective antibiotics, and rudimentary internal fixation methods like wires or plates that often failed under stress.[16] Despite these setbacks, Borggreve's work laid the conceptual groundwork for future refinements, demonstrating the potential of rotational osteotomy in preserving biological tissues for enhanced functionality.[17]

Modern Adoption and Variations

The procedure gained prominence in the mid-20th century through the work of Dutch orthopedic surgeon Cornelis Pieter van Nes, who in 1950 reported successful outcomes from rotationplasty cases, adapting the earlier conceptual approach introduced by Borggreve in the 1920s for femoral deficiencies by rotating the tibia and fibula to align with the remaining femur. Van Nes detailed this modification in a seminal publication in The Journal of Bone and Joint Surgery, emphasizing its utility for congenital short femur by utilizing the ankle joint as a functional knee equivalent in prosthetic fitting.[18] Van Nes reported successful outcomes in multiple cases, establishing it as a viable reconstructive option for proximal femoral deficiencies.[19] Following van Nes's contributions, adoption of rotationplasty expanded significantly after advances in chemotherapy during the 1970s, which improved survival rates for osteosarcoma and enabled greater emphasis on limb salvage over amputation. The application of rotationplasty to oncologic resections was pioneered by Salzer et al. in 1981, who popularized it for skeletally immature patients with osteosarcoma of the distal femur.[20] This shift facilitated broader application of the technique in tumor management around the knee, with variations emerging to address diverse anatomical needs, including knee rotationplasty (KRP) for distal femoral resections and tibial turnover procedures for proximal tibial tumors.[21] More recent adaptations for congenital femoral deficiency (CFD) include five innovative techniques developed by Dr. Dror Paley in 2021, tailored to the Paley classification system to optimize rotation and fusion for severe cases.[14] Key milestones in the procedure's evolution include a 2007 review in Clinical Orthopaedics and Related Research, which reaffirmed rotationplasty's role in bone tumor reconstruction by demonstrating effective local control and functional preservation in selected patients. Additionally, a 2019 study on long-term outcomes for osteosarcoma patients undergoing rotationplasty reported sustained functional benefits and high patient satisfaction compared to endoprosthetic alternatives, underscoring its enduring value in pediatric oncology.

Surgical Procedure

Preoperative Assessment

The preoperative assessment for rotationplasty is a critical step in evaluating patients, particularly those with osteosarcoma or other malignant bone tumors around the knee, to determine surgical feasibility and optimize outcomes. This process involves a comprehensive evaluation to confirm the absence of contraindications, such as significant sciatic nerve dysfunction or inadequate vascular supply, while ensuring the procedure aligns with the patient's overall health and functional goals.[3] A multidisciplinary team typically coordinates the assessment, including orthopedic oncologists for tumor management, vascular surgeons to evaluate vessel patency, psychologists or mental health specialists for emotional readiness, and prosthetists to advise on future limb adaptation. Rehabilitation physicians, physiotherapists, and nurses may also contribute to planning, ensuring integrated care from evaluation through long-term follow-up. This collaborative approach helps address the complex physical, psychological, and prosthetic needs unique to rotationplasty.[22][23][24] Diagnostic imaging plays a central role in delineating tumor extent and ruling out metastasis. Magnetic resonance imaging (MRI) and computed tomography (CT) scans assess soft tissue involvement and bone destruction, while angiography or angio-CT confirms vascular integrity and identifies any encasement requiring reconstruction. Bone scans, such as 99mTc scintigraphy, are used for staging to detect distant metastases, often complemented by chest CT for pulmonary evaluation. Full-length standing radiographs help estimate limb length discrepancies and growth potential in pediatric cases.[22][23][25] Functional assessment evaluates the patient's baseline capabilities to predict postoperative adaptation. This includes gait analysis to document pre-existing mobility patterns, testing of ankle range of motion and plantar flexion strength to ensure sufficient function for prosthetic use, and assessment of lower limb innervation and vascularization via tools like the ankle-brachial index. Psychological evaluation focuses on body image acceptance and coping mechanisms, screening for potential distress related to the procedure's cosmetic alterations.[3][22][26] Patient education is essential for informed consent, involving detailed discussions of cosmetic changes, such as the rotated foot appearing as a "knee" joint, prosthetic requirements, and expected functional benefits like improved mobility over above-knee amputation. Multiple consultations, including interactions with prior patients or visual aids, prepare individuals psychologically; for pediatric cases, family counseling addresses long-term implications and support needs to foster acceptance.[3][23][22]

Operative Technique

The operative technique for rotationplasty involves a multidisciplinary approach, typically performed by orthopedic oncologists, to resect the affected bone segment while preserving key neurovascular structures for functional reconstruction. General anesthesia is administered, and the patient is positioned supine on a radiolucent operating table to facilitate intraoperative imaging with fluoroscopy. The affected limb is prepared and draped free, with posterior and anterior tibial pulses marked preoperatively for continuous monitoring during the procedure. A tourniquet may be applied to the proximal thigh if deemed appropriate to control bleeding, though its use is optional depending on tumor extent and vascular considerations.[27][12] The surgical incision is typically a lazy S-shaped cut over the knee joint, beginning proximally and laterally, crossing anteriorly at the joint line, and curving medially and distally to provide wide exposure while minimizing tension on the skin flaps. Soft tissue dissection proceeds meticulously to identify and protect the sciatic nerve, which is freed along its course and preserved intact to maintain innervation to the rotated segment. The popliteal artery and vein are similarly safeguarded, with collateral and cruciate ligaments divided after capsulotomy of the knee joint. Muscles are systematically detached: the biceps femoris and pes anserinus laterally and medially, the gastrocnemius heads (with their nerve supply intact), the patellar tendon, and posterior structures such as the semimembranosus and popliteal muscles. The peroneal nerve is identified early and protected. Resection follows oncologic margins, excising the tumor-involved bone—commonly the distal femoral epiphysis and metaphysis, along with the proximal tibial epiphysis and metaphysis—using osteotomies approximately 5 mm into healthy metaphysis if feasible, while ensuring wide soft tissue margins. Preoperative vessel mapping enables this preservation, allowing safe manipulation without compromising distal perfusion.[27][28][3] Following resection, the distal leg segment is externally rotated 180 degrees, positioning the ankle joint to articulate with the remaining proximal femur remnant and function as the new knee. Vascular integrity is confirmed intraoperatively using Doppler ultrasonography to detect any compromise, with additional dissection or segmental shortening performed if tension on the neurovascular bundle is noted. Alignment is adjusted to ensure the foot points posteriorly, optimizing prosthetic fit. Fixation is achieved by arthrodesing the tibia to the femur, commonly with an intramedullary Rush rod secured by a cross-pin, or alternatively with plates and screws for stability; external fixators may be used in select cases, though cast immobilization is rare. The procedure typically requires 6 to 10 hours, varying with tumor complexity and reconstruction needs.[27][29][30] Variations adapt the technique to specific pathologies; for proximal femoral lesions (e.g., types BI or BII per Winkelmann classification), up to three-quarters of the femur may be resected, potentially involving the ischium and requiring additional osteotomies for pelvic stability. In congenital femoral deficiency, supplementary osteotomies address limb length discrepancies. If vessels are involved, as in revision for infected prostheses, they are transected en bloc and reanastomosed—such as femoral to popliteal or posterior tibial artery—under microscopic guidance prior to final fixation.[30][28][31] Closure is performed in layers: muscles are reapproximated (e.g., rectus femoris to gastrocnemius where applicable), fascia and subcutaneous tissues sutured, and skin closed primarily. Suction drains are placed to prevent hematoma formation, and the limb is immobilized in a sterile dressing.[27][30]

Postoperative Care and Rehabilitation

Immediate Postoperative Management

Following rotationplasty, patients typically remain hospitalized for 4 to 7 days to ensure initial stability and monitor for acute issues.[32][29] During this period, intravenous antibiotics, such as cefazolin, are administered prophylactically starting at induction and continuing postoperatively for 48 hours to prevent infection.[32] Pain is managed with a multimodal approach, including continuous epidural analgesia for the first 48 to 72 hours, transitioning to oral opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) as tolerated.[32] The operated limb is immobilized immediately after surgery using a plaster cast or spica cast, often supplemented by internal fixation with plates, screws, or rods, with the initial cast maintained for 6 to 8 weeks and reduced support (e.g., brace) possibly extending protection up to 12 weeks to promote bone healing.[32][29] Elevation of the limb is standard to minimize swelling, with the cast changed around 2 weeks postoperatively to inspect the surgical site. Venous thromboembolism prophylaxis, such as low-molecular-weight heparin, is routinely provided due to the risk of clotting in the immobilized state.[29] Close monitoring occurs in the intensive care unit for the first 24 to 48 hours, with frequent neurovascular assessments every 1 to 2 hours, including Doppler ultrasound for circulation and checks for signs of infection or compartment syndrome. Nerve function is evaluated daily, and blood tests are performed to assess coagulation parameters and inflammatory markers. By day 1 or 2, early mobilization begins with bedside exercises, such as active ankle range of motion and gentle hip movements within safe limits (e.g., hip flexion under 60 to 80 degrees), progressing to wheelchair transfers by the end of the first week to prevent secondary complications like muscle atrophy.[32][33]

Rehabilitation Protocol

The rehabilitation protocol for rotationplasty is a phased, multidisciplinary program aimed at progressively restoring joint mobility, muscle strength, and gait function following the initial postoperative immobilization, typically lasting 6 to 12 months. This approach emphasizes early intervention to prevent contractures in the rotated limb while building toward functional independence, with therapy sessions occurring 3 to 5 times per week in inpatient or outpatient settings.[34][35] Phase 1 (weeks 1-6): This initial stage prioritizes wound healing, edema control, and gentle mobilization of the neo-knee (formed by the rotated ankle) and hip, with patients remaining non-weight bearing and using wheelchairs or crutches for transfers. Exercises include isometric contractions of the gluteals and quadriceps (held for 5-10 seconds, 3 sets of 20 repetitions) and passive range of motion for ankle dorsiflexion and plantarflexion to maintain flexibility and promote circulation, performed 2-3 times daily under supervision.[34][35] Phase 2 (weeks 6-12): As bone healing progresses and immobilization is reduced (often after cast removal around 6-8 weeks), the focus shifts to active-assisted range of motion, muscle strengthening, and basic gait training. Activities involve leg lifts to 30 degrees, weight-shifting exercises on a stable surface (3 sets of 40 repetitions), and parallel bar walking with crutches to develop coordination and balance, advancing from partial to full non-prosthetic support.[34][36] Phase 3 (3-6 months): Advanced strengthening, proprioception, and endurance training dominate, incorporating resisted exercises (e.g., with bands or light weights), single-leg balance drills, and simulated daily activities like stair climbing to enhance stability and efficiency. Sessions build tolerance for prolonged activity, preparing for higher-level function.[34][35] A multidisciplinary team coordinates care, with physical therapists leading exercise progression, occupational therapists addressing activities of daily living such as dressing and self-care, and prosthetists consulting from approximately month 2 to align therapy with future device integration. Key milestones include initiation of partial weight-bearing at 6-8 weeks upon radiographic confirmation of union, achievement of independent crutch-assisted walking by 3-6 months, and progression to unassisted ambulation by 6 months in most cases. Return to age-appropriate sports or high-impact activities is generally feasible by 1 year, contingent on strength recovery (e.g., muscle grading 5/5).[34][36][1] In pediatric patients, who comprise the majority of rotationplasty cases (mean age around 7 years), the protocol incorporates play-based elements—such as games involving balance balls or obstacle courses—to improve engagement, compliance, and neurodevelopmental outcomes during all phases.[34][36]

Prosthetics and Functional Outcomes

Prosthetic Design and Fitting

The prosthetic design for rotationplasty is tailored to leverage the rotated lower leg, where the ankle joint functions as the new knee, enabling a below-knee style socket that attaches directly to the residual limb at this site. This socket typically incorporates a flexible inner liner for comfort and an outer shell, often reinforced with lightweight materials, connected to a pylon and an energy-storing prosthetic foot component that facilitates shock absorption and energy return during gait. The design emphasizes body-powered control, with the rotated ankle powering knee flexion and extension through natural muscle activation, while myoelectric options remain rare due to the unique anatomical configuration and reliance on lower leg musculature.[1][37][23] Fitting begins with a temporary prosthesis, often molded preoperatively based on the patient's foot dimensions, to allow early mobilization once the incision heals and swelling subsides, typically 4-8 weeks postoperatively. A custom permanent prosthesis is then fitted around 6-12 months after surgery, with a median time of approximately 7-8 months for patients undergoing the procedure for oncologic reasons, enabling most to achieve independent walking. In pediatric cases, which comprise the majority, regular adjustments are necessary to accommodate growth, often requiring socket replacements every 1-2 years to maintain proper alignment and fit.[1][38][39] Adaptation to the prosthesis involves training the patient to utilize the rotary motion of the rotated ankle for prosthetic knee control, with physical therapy focusing on strengthening the calf muscles to drive flexion and learning compensatory patterns for stability. This process integrates with gait training to optimize energy efficiency, as the design allows the prosthetic foot to mimic natural heel-to-toe progression despite the 180-degree rotation.[1][39][37] Innovations in prosthetic design for rotationplasty include the incorporation of lightweight carbon fiber for sockets and pylons, reducing overall weight compared to traditional laminates while enhancing durability and energy storage in the foot component. Post-2010s advancements have introduced 3D-printed sockets, enabling precise customization through scanning and rapid prototyping, which improves fit for the irregular residual limb shape and shortens fabrication time to days rather than weeks.[23][40][41]

Functional Advantages

Rotationplasty offers significant mobility gains by preserving proprioception and joint function in the lower leg, which facilitates a near-normal gait pattern after rehabilitation. The rotated ankle serves as a functional knee joint, allowing for active control and efficient propulsion during ambulation, with studies showing reduced compensatory movements compared to traditional amputations.[23] This preservation enables patients to participate in high-impact activities such as running, skiing, wrestling, and cycling, with reports of individuals returning to competitive sports and even pursuing Paralympic training.[42][3] Compared to above-knee amputation, rotationplasty demonstrates superior biomechanical efficiency, with a 2025 systematic review and meta-analysis (as of August 2025) indicating approximately 12.5% lower oxygen and energy cost during walking, leading to improved endurance for daily activities and prolonged ambulation.[43] Additionally, it requires fewer surgical revisions than growing endoprostheses, which often necessitate multiple interventions for lengthening and complication management, providing a more stable long-term reconstruction for skeletally immature patients.[3] The procedure's durability supports active lifestyles in youth, particularly tumor survivors, with a 2007 study reporting excellent functional outcomes, with 85% of patients engaging in sports activities, though with higher energy expenditure compared to age-matched healthy individuals, enabling sustained participation in sports and physical demands over decades.[44] A 2016 report from Johns Hopkins highlighted patients achieving high levels of mobility, including gymnastics and long-distance cycling, underscoring rotationplasty's role in restoring substantial function through optimized prosthetic integration.[42]

Risks, Complications, and Disadvantages

Surgical Risks

Rotationplasty, a complex orthopedic procedure involving the rotation of the lower leg to replace the knee joint, carries several immediate perioperative risks inherent to its extensive soft tissue and vascular manipulation. One of the most critical hazards is vascular compromise, including thrombosis or ischemia, which can occur due to kinking, poor venous drainage, or failed anastomosis following vessel rotation or reconstruction. Reported rates of vascular compromise range from 3.7% to 15.4% across studies, with some series documenting up to 12% incidence leading to limb-threatening ischemia or amputation if not addressed promptly.[28][10] These risks are mitigated through preoperative vascular assessment using arteriography or duplex scanning to evaluate vessel patency and plan the surgical approach, alongside intraoperative monitoring with pulse oximetry to maintain distal oxygen saturation above 90%.[22] Infection represents another significant perioperative concern, encompassing superficial wound infections or deeper septic complications that can delay healing and necessitate additional interventions. Incidence rates vary, with studies reporting around 4% in primary cases.[10] Prevention strategies include perioperative antibiotic prophylaxis and adherence to sterile techniques, which have been shown to reduce the overall infection burden in major orthopedic surgeries like rotationplasty.[28][45][10] Nerve injury, particularly to the sciatic or peroneal nerves, is a rarer but potential intraoperative risk, potentially resulting in foot drop or sensory deficits due to stretching or compression during limb rotation and closure. Such injuries occur in less than 5% of cases, with one series noting a 4% incidence of transient sciatic palsy resolved by immediate decompression. Intraoperative nerve monitoring and careful soft tissue handling help minimize this risk.[10][28] Bleeding and anesthesia-related risks align with those of major orthopedic procedures, including substantial intraoperative blood loss typically ranging from 500 to 1000 mL due to extensive dissection and osteotomies. Excessive hemorrhage, such as around vascular anastomoses, can exacerbate ischemia and may require transfusion or revision, though standard protocols for hemostasis and anesthetic management effectively control most cases.[1] Intraoperative specifics, such as bone fracture during rotation or early fixation failure, pose additional acute threats, though these are infrequent and often linked to underlying bone quality compromised by tumor or prior treatment. While not quantified in all series, such events can prolong surgery and increase bleeding, underscoring the need for meticulous osteotomy planning and stable internal fixation to ensure immediate structural integrity.[10]

Long-term Complications

Bone-related complications in rotationplasty, such as non-union at the fusion site, occur in a minority of cases but can lead to pain, instability, and the need for revision surgery. In a series of 25 patients followed for an average of 5.5 years, one non-union developed 41 months postoperatively and was treated with revision osteosynthesis and bone grafting.[46] Recent studies indicate reoperation rates around 15% linked to persistent issues like bone healing problems.[47] In pediatric patients, where rotationplasty is most commonly performed, ongoing monitoring is essential to address potential leg length discrepancies or angular deformities related to growth.[48] Prosthetic-related challenges arise from the unique rotated anatomy, where the foot is positioned posteriorly within the socket, leading to socket irritation and skin breakdown. The 180-degree rotation compresses soft tissues, increasing pressure points inside the prosthesis and predisposing patients to chafing, excessive perspiration, and abrasions, particularly during prolonged use.[4] Common manifestations include verrucous hyperplasia over the toes due to friction and poor distal fit, as well as blisters and callosities that limit prosthetic tolerance and require frequent socket modifications.[49] Other long-term issues include phantom limb sensations, which are notably less prevalent than in traditional above-knee amputations since peripheral nerves remain intact and connected to functional tissues.[46] Additionally, the neo-knee—formed by the rotated ankle joint—experiences biomechanical overload, potentially resulting in degenerative arthritis over time. A 2002 study of 22 patients over 10 years documented 21 revisions across eight individuals for various issues, highlighting the cumulative burden of such complications.[50] Similarly, a 2019 analysis of osteosarcoma cases reported a 15% reoperation rate linked to persistent long-term problems like joint degeneration.[47] Recent reviews as of 2023 confirm that complication profiles, including vascular and infectious risks, remain consistent, with good long-term function in most patients.[51][7] Management of these complications emphasizes serial prosthetic adjustments to alleviate socket pressures and prevent skin breakdown, alongside secondary surgeries such as bone grafting for non-unions or debridement for arthritic changes in the neo-knee.[46] Regular multidisciplinary follow-up, including orthopedic and prosthetist input, is essential to address growth-related concerns in children through timely corrections.[48]

Quality of Life and Psychological Aspects

Physical Quality of Life

Patients undergoing rotationplasty often report physical quality of life metrics comparable to the general population, as assessed by standardized tools like the SF-36 questionnaire. In a 2015 study of 12 patients with a mean follow-up of 14 years, SF-36 physical functioning scores averaged 80.4 ± 15.7, aligning closely with normative values for healthy adults (typically around 84 for this subscale), while role-physical scores were 78.1 ± 24.1, indicating robust daily physical capabilities.[52] A 2019 analysis of eight rotationplasty patients with over 18 years of follow-up similarly found physical health scores on the Rand SF-36 averaging 46.4 (norm-based, where 50 represents the population mean), with overall functioning in line with peers when fitted with appropriate prostheses, supporting sustained physical well-being long-term.[53] Independence in activities of daily living (ADLs) is notably high among rotationplasty recipients, enabling most to manage personal care, mobility, and household tasks without assistance. Studies highlight that patients achieve good functional outcomes in ADLs.[54] Return to school and work is common in pediatric and young adult cohorts, reflecting effective reintegration into educational and occupational routines post-rehabilitation.[49] Athletic participation is well-documented, with case evidence showing rotationplasty patients engaging in competitive sports, including Paralympic-level events.[55] Rotationplasty avoids phantom limb pain and preserves more limb length for better weight-bearing and gait efficiency.[10] In pediatric cases, rotationplasty accommodates natural growth better than rigid endoprosthetic reconstructions, as the remaining bone continues to elongate with the child, allowing prosthetic adjustments without frequent invasive revisions—unlike megaprostheses, which often necessitate multiple surgeries for lengthening and complication management.[56]

Emotional and Social Impacts

The unusual appearance of the rotated limb, featuring the foot positioned backward to function as a knee joint, frequently presents initial challenges to body image and leads to psychological distress for patients and families following rotationplasty. This cosmetic difference can evoke feelings of self-consciousness, particularly in social and intimate settings, with nearly half of patients in one review reporting impacts on sexuality and interpersonal contact.[3] Comprehensive pre- and post-operative counseling is recommended to address these concerns, helping patients and families process the aesthetic changes and build emotional resilience through education on long-term benefits.[3] Younger patients often demonstrate superior adaptation to body image alterations compared to older individuals, with a 2002 cohort study of 22 long-term survivors reporting psychosocial functioning comparable to the general population, and high overall acceptance of the procedure.[50][57] Social outcomes post-rotationplasty are generally positive, with minimal disruption to relationships and sustained high self-esteem, especially among physically active patients. A 2023 study of knee rotationplasty survivors found elevated post-traumatic growth, emotional well-being, and life satisfaction, independent of gender, underscoring robust psychosocial integration. Similarly, a 2021 analysis of rotationplasty for congenital femoral deficiency noted universal patient satisfaction and emotional contentment, despite cosmetic variances, attributing this to early intervention supporting psychological adaptation.[26][58] Research gaps persist regarding long-term mental health in adult rotationplasty patients, as most studies focus on pediatric cohorts with follow-up extending into young adulthood. Data on social stigma, particularly in non-Western cultural contexts where aesthetic norms may heighten rejection, remain limited, highlighting the need for broader, diverse investigations.[26][50]

References

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  2. Surgical Procedures: Rotationplasty | OncoLink
  3. Rotationplasty: Beauty is in the Eye of the Beholder - PMC - NIH
  4. Rotationplasty - Physiopedia
  5. Definition of rotationplasty - NCI Dictionary of Cancer Terms
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  17. Modified Borggreve–Van Nes-Winkelmann rotationplasty for surgery ...
  18. Congenital Short Femur - SpringerLink
  19. Long-term follow-up of Van Nes rotationplasty in patients with ... - NIH
  20. Fifty Years of Bone Tumors - PMC - NIH
  21. Knee rotationplasty: motion of the body centre of mass during walking
  22. Vascular Management in Rotationplasty - PMC - NIH
  23. Rotationplasty Salvage Procedure as an Effective Alternative ... - NIH
  24. Rotationplasty type BIIIb as an effective alternative to limb salvage ...
  25. Van Nes rotationplasty as a treatment method for Ewing's sarcoma ...
  26. Psychological Well-Being, Self-Esteem, Quality of Life and Gender ...
  27. Rotationplasty: Surgical Techniques and Prosthetic Considerations
  28. Rotationplasty with Vascular Reconstruction for Prosthetic Knee ...
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  31. Rotationplasty: An Option for Limb Salvage in Childhood ...
  32. https://aornjournal.onlinelibrary.wiley.com/doi/10.1016/S0001-2092(06
  33. Case Report: Winkelmann hip rotationplasty as a last-resort solution
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  35. Functional rehabilitation and long‑term efficacy of rotationplasty in ...
  36. [PDF] Physical Therapy After Your Rotationplasty
  37. [PDF] Physiotherapy treatment for rotationplasty - ACM 2021 03 vJ.indd
  38. Rotationplasty Treatment at Emory Orthopaedic Oncology
  39. Prosthetic fitting after rotationplasty of the knee - PubMed
  40. Rehabilitation and Prosthetic Design after Van Nes Rotationplasty of ...
  41. Rotationplasty Prosthetics
  42. https://ieeexplore.ieee.org/document/8735612
  43. When Rotationplasty Is the Right Fit | Johns Hopkins Medicine
  44. Gait biomechanics and energy cost of walking after rotationplasty: A ...
  45. Sports activities and endurance capacity of bone tumor patients after ...
  46. Effectiveness of Salvage Knee Rotationplasty on Sarcoma Around ...
  47. Complications and risk factors for failure of rotationplasty - PubMed
  48. Long-term clinical and functional outcomes after treatment ... - PubMed
  49. [Endoprosthesis Management of the Extremities of Children After ...
  50. Prosthetic Management of Rotationplasty in Children - The O&P EDGE
  51. None
  52. Rotationplasty--quality of Life After 10 Years in 22 Patients - PubMed
  53. Long-Term Outcomes of Rotationplasty patients in the treatment of ...
  54. Long-term functional outcome and quality of life following ...
  55. Long-Term Outcomes of Rotationplasty patients in the treatment of ...
  56. Long-term functional outcome and quality of life following ... - NIH
  57. First-year medical student wins gold at Paralympics
  58. Long-Term Outcomes of Rotationplasty patients in the treatment of ...
  59. Is Rotationplasty Still a Reasonable Reconstruction Option for ...
  60. https://doi.org/10.3390/children8060462
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