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Tableting
Tableting is a method of pressing medicine or candy into tablets. Confectionery manufacture shares many similarities with pharmaceutical production.
A powder or granule mixture is prepared, a die mold is filled, and then the mixture is compressed and ejected. While drug tablets are constrained to shapes and sizes that can be swallowed easily, candy tablets are designed to be chewable and can take a wider variety of shapes and sizes.
Examples of tablet candy include Smarties, SweeTarts, and Necco Wafers.
The manufacture of oral solid dosage forms such as tablets is a complex multi-stage process under which the starting materials change their physical characteristics a number of times before the final dosage form is produced.
Traditionally, tablets have been made by granulation, a process that imparts two primary requisites to formulate: compatibility and fluidity. Both wet granulation and dry granulation (slugging and roll compaction) are used. The first step, milling and mixing, is the same whether making tablets by direct compression or granulation; subsequent steps vary.
Numerous unit processes are involved in making tablets, including particle size reduction and sizing, blending, granulation, drying, compaction, and (frequently) coating. Various factors associated with these processes can seriously affect content uniformity, bioavailability, or stability.
Sizing (size reduction, milling, crushing, grinding, pulverization) is an important step in the process of tablet manufacturing.
In manufacturing of compressed tablets, the mixing or blending of several solid pharmaceutical ingredients is easier and more uniform if the ingredients are about the same size. This provides a greater uniformity of dose. A fine particle size is essential in the case of lubricant mixing with granules for its proper function.
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Tableting
Tableting is a method of pressing medicine or candy into tablets. Confectionery manufacture shares many similarities with pharmaceutical production.
A powder or granule mixture is prepared, a die mold is filled, and then the mixture is compressed and ejected. While drug tablets are constrained to shapes and sizes that can be swallowed easily, candy tablets are designed to be chewable and can take a wider variety of shapes and sizes.
Examples of tablet candy include Smarties, SweeTarts, and Necco Wafers.
The manufacture of oral solid dosage forms such as tablets is a complex multi-stage process under which the starting materials change their physical characteristics a number of times before the final dosage form is produced.
Traditionally, tablets have been made by granulation, a process that imparts two primary requisites to formulate: compatibility and fluidity. Both wet granulation and dry granulation (slugging and roll compaction) are used. The first step, milling and mixing, is the same whether making tablets by direct compression or granulation; subsequent steps vary.
Numerous unit processes are involved in making tablets, including particle size reduction and sizing, blending, granulation, drying, compaction, and (frequently) coating. Various factors associated with these processes can seriously affect content uniformity, bioavailability, or stability.
Sizing (size reduction, milling, crushing, grinding, pulverization) is an important step in the process of tablet manufacturing.
In manufacturing of compressed tablets, the mixing or blending of several solid pharmaceutical ingredients is easier and more uniform if the ingredients are about the same size. This provides a greater uniformity of dose. A fine particle size is essential in the case of lubricant mixing with granules for its proper function.