ESPCI Paris (officially the École supérieure de physique et de chimie industrielles de la ville de Paris, pronounced [ekɔl sypeʁjœʁ də fizik e də ʃimi ɛ̃dystʁijɛl də la vil də paʁi], "The City of Paris Industrial Physics and Chemistry Higher Educational Institution") is a grande école founded in 1882 by the city of Paris, France. It educates undergraduate and graduate students in physics, chemistry and biology and conducts high-level research in those fields. It is ranked as the first French École d'Ingénieurs in the 2017 Shanghai Ranking.

ESPCI Paris is a constituent college of Université PSL and a founding member of the ParisTech (Paris Institute of Technology) alliance.

Two thirds of the students enter the school following a competitive examination (concours X-ESPCI-ENS) following at least two years of Classes Préparatoires. The other students are recruited by submitting applications. The school itself is also known as Physique-Chimie or simply PC.

ESPCI Paris nurtures relationships with many industrial partners such as Schlumberger, Rhodia, TotalEnergies, Thales, Arkema, Michelin, Withings, which sponsors groups of students and has research contracts with ESPCI laboratories. ESPCI Paris also has partnerships with L'Oréal and Saint-Gobain for professional recruitment.

At the end of the 19th century, following the annexation of Alsace and Lorraine by Germany, France lost the École de Chimie de Mulhouse (Mulhouse Chemistry School), which was at that time the best chemistry school in the country. One of its professors, Charles Lauth, obtained permission from the government in 1878 to create a Grande École. In 1882 the École Supérieure de Chimie Industrielles de la Ville de Paris was established and became ESPCI, its current name, in 1948. Since its foundation, the founders of the school have emphasized pluridisciplinarity. Biology was introduced in 1994. There are no tuition fees at ESPCI.

After its establishment, the school rapidly became a meeting spot for the best scientists. From 1880 on, Pierre and Jacques Curie started a serie of research on crystal electrical properties that led to the piezoelectricity discovery. In 1897, Marie Curie started her work on uranic rays discovered by Becquerel one year earlier. After numerous experiments in the ESPCI laboratories, she discovered that pitchblende was 4 times more radioactive than uranium or thorium. In July 1898, the Curies announced the discovery of polonium and in December of the same year that of radium. Pierre and Marie Curie received the Physics Nobel Prize in 1903. After the death of her husband, Marie Curie was granted the Chemistry Nobel Prize in 1911.

Many former students have distinguished themselves, amongst which are Georges Claude (5th year), founder of Air Liquide, Paul Langevin (7th year), physicist and inventor and Frédéric Joliot-Curie (39th year), founder of the CEA and Nobel Prize in Chemistry in 1935 with his wife Irène Joliot-Curie.

In 1976, Pierre-Gilles de Gennes (Nobel Prize 1991) became Director of the school and remained in this position until his retirement in 2002.