Guidizzolo (Upper Mantovano: Ghidisöl) is a comune (municipality) in the Province of Mantua in the Italian region Lombardy, located about 110 kilometres (68 mi) east of Milan and about 25 kilometres (16 mi) northwest of Mantua. The bordering municipalities of Guidizzolo are Cavriana, Ceresara, Goito, Medole and Solferino.

The most ancient edifice is the Oratory of St. Lawrence, a small Romanesque architecture devotional building dating from the 13th century.

The territory of Guidizzolo consists of the central core and three hamlets: Birbesi and Rebecco, located to the south-east, and Selvarizzo, located south-west of the main centre. It belongs to the sub-hilly area at the foot of the heights bordering Lake Garda towards the Po Valley.

The town is about 30 km from Mantua, 40 km from Brescia and Verona and 20 km from Lake Garda.

According to the Seismic Classification, the municipality belongs to zone 3 (medium-low seismicity).

The cycle path running along the Virgilio canal towpath makes it possible to retrace transversally - along the ideal east-west axis represented by the canal - a large portion of the foothills territory, from Guidizzolo to arrive near the Mincio river by connecting to the Mincio cycleway.

Guidizzolo's climate is typical of the upper Po Valley of the temperate sub-continental type: winters are moderately harsh, with little rain and foggy days; summers are hot and muggy with thunderstorms; springs and autumns are generally rainy.

Climate classification: zone E 2428 62.