3',5'-cyclic-AMP phosphodiesterase

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3′,5′-cyclic-AMP phosphodiesterase
3′,5′-cyclic-AMP phosphodiesterase
Identifiers
EC no.	3.1.4.53
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

3′,5′-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3′,5′-cyclic-AMP 5′-nucleotidohydrolase.^[1]^[2]^[3]^[4]^[5]^[6] It catalyses the following reaction

adenosine 3′,5′-cyclic phosphate + H₂O

\rightleftharpoons

AMP

This enzyme requires Mg²⁺ or Mn²⁺ for activity.

References

^ Alonso GD, Schoijet AC, Torres HN, Flawiá MM (January 2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Molecular and Biochemical Parasitology. 145 (1): 40–9. doi:10.1016/j.molbiopara.2005.09.005. hdl:11336/79656. PMID 16225937.
^ Bader S, Kortholt A, Snippe H, Van Haastert PJ (July 2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". The Journal of Biological Chemistry. 281 (29): 20018–26. doi:10.1074/jbc.M600040200. PMID 16644729.
^ Rascón A, Soderling SH, Schaefer JB, Beavo JA (April 2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4714–9. Bibcode:2002PNAS...99.4714R. doi:10.1073/pnas.002031599. PMC 123713. PMID 11930017.
^ Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiology. 6 25. doi:10.1186/1471-2180-6-25. PMC 1431542. PMID 16522215.
^ Lugnier C, Keravis T, Le Bec A, Pauvert O, Proteau S, Rousseau E (November 1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochimica et Biophysica Acta (BBA) - General Subjects. 1472 (3): 431–446. doi:10.1016/S0304-4165(99)00145-2. PMID 10564757.
^ Imamura R, Yamanaka K, Ogura T, Hiraga S, Fujita N, Ishihama A, Niki H (October 1996). "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". The Journal of Biological Chemistry. 271 (41): 25423–9. doi:10.1074/jbc.271.41.25423. PMID 8810311.

External links

3',5'-cyclic-AMP+phosphodiesterase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[1] Alonso GD, Schoijet AC, Torres HN, Flawiá MM (January 2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Molecular and Biochemical Parasitology. 145 (1): 40–9. doi:10.1016/j.molbiopara.2005.09.005. hdl:11336/79656. PMID 16225937.

[2] Bader S, Kortholt A, Snippe H, Van Haastert PJ (July 2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". The Journal of Biological Chemistry. 281 (29): 20018–26. doi:10.1074/jbc.M600040200. PMID 16644729.

[3] Rascón A, Soderling SH, Schaefer JB, Beavo JA (April 2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4714–9. Bibcode:2002PNAS...99.4714R. doi:10.1073/pnas.002031599. PMC 123713. PMID 11930017.

[4] Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiology. 6 25. doi:10.1186/1471-2180-6-25. PMC 1431542. PMID 16522215.

[5] Lugnier C, Keravis T, Le Bec A, Pauvert O, Proteau S, Rousseau E (November 1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochimica et Biophysica Acta (BBA) - General Subjects. 1472 (3): 431–446. doi:10.1016/S0304-4165(99)00145-2. PMID 10564757.

[6] Imamura R, Yamanaka K, Ogura T, Hiraga S, Fujita N, Ishihama A, Niki H (October 1996). "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". The Journal of Biological Chemistry. 271 (41): 25423–9. doi:10.1074/jbc.271.41.25423. PMID 8810311.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

3',5'-cyclic-AMP phosphodiesterase

3',5'-cyclic-AMP phosphodiesterase

3',5'-cyclic-AMP phosphodiesterase

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3',5'-cyclic-AMP phosphodiesterase

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