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Sebaceous hyperplasia
Sebaceous hyperplasia
Sebaceous hyperplasia
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Sebaceous hyperplasia
Sebaceous hyperplasia in 55-year-old woman. Diagnosis was histologically verified.
SpecialtyDermatology

Sebaceous hyperplasia is a disorder of the sebaceous glands in which they become enlarged, producing flesh-colored or yellowish, shiny, often umbilicated bumps.[1] Sebaceous hyperplasia, primarily affecting older patients in high-concentration areas like the face, head, and neck, typically has a 2-4 mm diameter and causes no symptoms. The lesions are often surrounded by telangiectatic blood vessels, also known as "crown vessels," and a central dell, which is in line with the origin of the lesions.

Sebaceous glands are glands located within the skin and are responsible for secreting an oily substance named sebum. They are commonly associated with hair follicles but they can be found in hairless regions of the skin as well. Their secretion lubricates the skin, protecting it from drying out or becoming irritated.[2]

Murine studies suggest topical irritants and carcinogens may contribute to sebaceous hyperplasia development, with immunosuppression with cyclosporin A or HIV infection increasing the likelihood.

Sebaceous hyperplasia is a condition that can be diagnosed clinically but requires a biopsy for confirmation. It shares similarities with folliculosebaceous unit architecture but has larger and expanded sebaceous glands. Identifying sebaceous hyperplasia using dermatoscopy can help identify it from other lesions. The dermoscopic characteristics include "crown vessels" clusters of white or yellow nodules, a distinct asymmetrical milky-white structure called the cumulus sign, and a central umbilication called the "bonbon toffee sign."

Sebaceous hyperplasia treatment involves various techniques like cryotherapy, bichloroacetic acid, shave excision, carbon dioxide laser ablation, electrodessication, erbium/yttrium aluminum garnet laser ablation, and pulsed-dye laser photothermolysis.

Signs and symptoms

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Sebaceous hyperplasia primarily affects older patients in areas with high concentrations of sebaceous glands, such as the face, head, and neck.[3] It typically manifests as yellowish-colored skin with small papules that are often surrounded by telangiectatic blood vessels, also known as "crown vessels," and a central dell that is in line with the origin of the lesions, which is a dilated central follicular infundibulum.[4][5] Most lesions have a diameter of 2-4 mm and cause no symptoms.[6]

Causes

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Although the etiology is unknown, murine studies have revealed that topical irritants and carcinogens may be involved in the development of sebaceous hyperplasia.[7][8]

Immunosuppression with cyclosporin A[9] or HIV infection increases the likelihood of developing sebaceous hyperplasia significantly.[10]

Diagnosis

[edit]

Although sebaceous hyperplasia can be diagnosed clinically, a biopsy is necessary for confirmation in cases of doubt.[11] The differential diagnosis for sebaceous hyperplasia includes nevus sebaceous, sebaceous carcinoma, sebaceous adenoma, basal cell carcinoma, molluscum contagiosum, and small epidermal inclusion cysts.[6]

Sebaceous hyperplasia shares histopathological similarities with the typical architecture of the folliculosebaceous unit, but with larger and expanded sebaceous glands.[12][13]

To help identify sebaceous hyperplasia from other lesions, dermatoscopy may be utilized. A cluster of white or yellow nodules encircled by tiny, nonarborizing branching vessels known as "crown vessels" are among the dermoscopic characteristics of sebaceous hyperplasia.[14][15] On dermatoscopy, a distinct asymmetrical milky-white structure known as the cumulus sign has been identified in cases with sebaceous hyperplasia. Unlike the traditional crown vessels, some writers describe the blood vessels as "multiple tree-like branches."[16] A central umbilication encircled by the cumulus sign was another distinguishing characteristic of dermatoscopy; the authors dubbed this the "bonbon toffee sign."[17]

Treatment

[edit]

Treatment for sebaceous hyperplasia is carried out for cosmetic reasons. There are numerous techniques that have been reported, including cryotherapy, bichloroacetic acid, shave excision, carbon dioxide laser ablation, electrodessication, erbium or yttrium aluminum garnet laser ablation, and pulsed-dye laser photothermolysis.[18]

Additional photos

[edit]
  • Photography of sebaceous hyperplasia, showing a group of papules, in this case on the chest with linear distribution pattern
    Photography of sebaceous hyperplasia, showing a group of papules, in this case on the chest with linear distribution pattern
  • Dermoscopy of sebaceous hyperplasia. Note the aggregation of yellowish-white clods with linear vessels between or above the clods.
    Dermoscopy of sebaceous hyperplasia. Note the aggregation of yellowish-white clods with linear vessels between or above the clods.
  • Dermoscopy of sebaceous hyperplasia with digital high dynamic range. Note the multi-lobulated clods with central openings.
    Dermoscopy of sebaceous hyperplasia with digital high dynamic range. Note the multi-lobulated clods with central openings.
  • H&E staining of biopsied lesion of sebaceous hyperplasia: Note the multiple, mature sebaceous lobules attached to the central dilated duct in the upper dermis.
    H&E staining of biopsied lesion of sebaceous hyperplasia: Note the multiple, mature sebaceous lobules attached to the central dilated duct in the upper dermis.
  • Sebaceous hyperplasia, lateral right temple marked for biopsy with adjacent malignant melanoma in situ, evolving, medial right temple
    Sebaceous hyperplasia, lateral right temple marked for biopsy with adjacent malignant melanoma in situ, evolving, medial right temple
  • Sebaceous hyperplasia with surrounding chronic folliculitis, right mid chest
    Sebaceous hyperplasia with surrounding chronic folliculitis, right mid chest

See also

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References

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Further reading

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Revisions and contributorsEdit on WikipediaRead on Wikipedia

Sebaceous hyperplasia

View on Grokipedia
from Grokipedia
Sebaceous hyperplasia is a common, benign proliferation of sebaceous glands that manifests as small, soft, yellowish papules, typically 2-5 mm in diameter, with a central umbilication or dell, most often on the face such as the , cheeks, and . This condition arises from the enlargement of oil-producing sebaceous glands due to an accumulation of sebocytes and increased glandular acini surrounding hair follicles, leading to trapped sebum and the formation of these characteristic bumps. It is generally and poses no health risks or malignant potential, though it may be mistaken for due to its appearance. The etiology of sebaceous hyperplasia is multifactorial, primarily linked to age-related hormonal changes, such as declining levels, which slow sebocyte turnover and promote glandular hypertrophy. Other contributing factors include (UV) exposure, (e.g., from cyclosporine use in transplant patients, affecting 10-16% of such individuals), and rare associations with genetic syndromes like Muir-Torre syndrome. It is more prevalent in middle-aged and older adults, with a U.S. prevalence of approximately 1% in the general population, though transient cases occur in up to 43.7% of newborns. Risk factors encompass oily skin, , stress, hormonal fluctuations, and environmental , with no significant sex predilection beyond a slight male predominance in adults. Diagnosis is primarily clinical, based on the distinctive of yellowish papules with a central depression, often confirmed via dermoscopy revealing crown-like vessels or, if needed, showing enlarged sebaceous lobules (typically ≥4 acini per follicle) without . Differential diagnoses include , nevus sebaceus, and , particularly in immunosuppressed patients where it may correlate with higher nonmelanoma risk. Treatment is usually pursued for cosmetic reasons rather than medical necessity, with options ranging from topical retinoids and oral to procedural interventions like , (e.g., CO2 or pulsed dye), electrodessication, or ; however, recurrence is common, and procedures carry risks of scarring or pigmentation changes. Prognosis is excellent, as the condition is non-progressive and benign, though in rare eruptive forms or associated with , monitoring for is advised.

Definition and Epidemiology

Definition

Sebaceous hyperplasia is a benign proliferation of sebaceous glands, characterized by the enlargement of these oil-producing structures within the skin, leading to the formation of small, yellowish papules. These lesions are typically soft and dome-shaped, measuring 2-5 mm in diameter, and often exhibit a central umbilication or dell corresponding to the follicular . The condition is most commonly observed on the face in middle-aged and older adults, though it remains a harmless entity without malignant potential.

Epidemiology

Sebaceous hyperplasia is a common benign with an estimated prevalence of approximately 1% in the healthy adult population, though rates can vary in specific cohorts such as organ transplant recipients, where it reaches 10-16% due to immunosuppressive therapy. The condition becomes increasingly prevalent with advancing age, rarely affecting children or adolescents but commonly emerging in middle-aged individuals and peaking in those over 60 years, particularly in the eighth decade of life for men and post-menopause for women. Demographically, sebaceous hyperplasia predominantly affects men, though it occurs in both genders. It is more frequent in individuals with fair , corresponding to Fitzpatrick skin types I-III, where lighter pigmentation may contribute to higher susceptibility. Geographically, the incidence appears higher in regions with greater sun exposure, such as sunny climates, reflecting the influence of chronic ultraviolet radiation on proliferation.

Pathophysiology and Causes

Pathophysiology

Sebaceous hyperplasia arises from benign enlargement of s due to of sebaceous lobules, characterized by increased proliferation and maturation of sebocytes without cellular . Sebocytes, the primary cells of these glands, originate from a peripheral layer of undifferentiated basaloid germinative cells and progress centrally to mature, lipid-laden forms that undergo to produce sebum. In this condition, the normal cycle—typically lasting about one month—is disrupted, leading to accumulation of sebocytes and glandular expansion. This process involves a feedback mechanism where reduced sebocyte turnover stimulates further proliferation, resulting in glands with multiple acini clustered around a central duct. The condition is closely tied to hormonal regulation, particularly the influence of s on activity. express androgen receptors and key enzymes such as 5-α-reductase type I, which convert weaker s into potent , thereby promoting sebocyte , increased metabolic rate, and sebum production. With advancing age, circulating levels decline, slowing the normal turnover of sebocytes and triggering compensatory to maintain glandular function. This hormonal shift, often an imbalance favoring reduced androgenic stimulation relative to estrogens—which suppress sebaceous activity—contributes to the excessive glandular growth observed in sebaceous hyperplasia. Other hormones, including insulin, , and , can also enhance sebocyte proliferation, amplifying the process. Microscopically, affected sebaceous glands appear enlarged with an increased number of normal-appearing lobules—typically four or more—attached to a dilated central duct connected to a . The peripheral rim consists of a thin layer (one to two cells thick) of basaloid germinative cells without expansion or , while the central portion is occupied by mature sebocytes exhibiting foamy, vacuolated due to accumulation and scalloped nuclei. These features distinguish sebaceous hyperplasia from malignant processes, as there is no nuclear pleomorphism, mitotic activity, or invasive growth. The overall architecture remains benign, reflecting a hyperplastic rather than neoplastic change.

Risk Factors and Causes

Sebaceous hyperplasia is associated with chronic (UV) radiation exposure, which damages sebaceous glands and acts as a key cofactor in its development, though lesions can occasionally appear in non-sun-exposed areas such as the buccal mucosa, , or areolae. significantly increases risk, particularly in organ transplant recipients on long-term cyclosporine therapy, where prevalence reaches 10-16%, and in individuals with on antiretroviral treatment. Genetic predisposition contributes in select cases, including presenile diffuse familial with earlier onset and familial clustering linked to higher density, as well as rare associations with Muir-Torre syndrome, a hereditary condition involving mismatch repair mutations and increased risk of sebaceous neoplasms alongside visceral malignancies. Hormonal influences play a role, with the condition often emerging in women post-menopause due to age-related hormonal changes, including declining levels that slow sebocyte turnover, as are androgen-sensitive and exhibit altered activity with age-related hormonal shifts. Certain medications, notably cyclosporine and , serve as triggers by promoting glandular proliferation in immunocompromised patients.

Clinical Presentation

Signs and Symptoms

Sebaceous hyperplasia typically presents as small, soft, yellowish or flesh-colored papules measuring 2 to 3 mm in diameter, often featuring a central umbilication or dell that corresponds to the dilated follicular . These lesions may appear solitary but are more commonly multiple, frequently occurring in clusters, particularly on the face. The condition is generally , with no associated pain or discomfort in most cases, though the visible bumps can lead to cosmetic concerns for affected individuals. In rare instances, mild irritation, itching, or tenderness may occur if the lesions are irritated by external factors. Lesions of sebaceous hyperplasia are benign and tend to remain stable over time, though they may slowly enlarge or increase in number with advancing age, without causing pain. They persist indefinitely without intervention but do not undergo spontaneous regression.

Affected Sites

Sebaceous hyperplasia most commonly affects the face, with lesions frequently appearing on the , cheeks, and . Rare secondary sites include the chest, , and . The condition typically spares palms, soles, and most mucous membranes, though exceptional cases involve the . Lesions often present in a symmetrical distribution on sun-exposed areas, particularly the face. In older adults, involvement tends to be more pronounced in the central facial regions.

Diagnosis

Clinical Evaluation

The clinical evaluation of sebaceous hyperplasia begins with a detailed history taking to contextualize the patient's presentation and identify contributing factors. Clinicians typically inquire about the patient's age, as the condition predominantly affects middle-aged and older adults, with reported in studies as approximately 1% in patients with a mean age of 51 years, increasing to 26% in those with a mean age of 82 years. A history of prolonged sun exposure is relevant, given its role in alterations, while inquiries into medications such as cyclosporine—particularly in transplant patients—can highlight iatrogenic associations. Patients often present due to cosmetic concerns over the appearance of these benign lesions, though they are generally unless irritated by trauma. Physical examination focuses on the characteristic features of the lesions, which appear as soft, pale yellow to skin-colored papules, typically 2-5 mm in diameter, with a central umbilication or dell corresponding to the dilated sebaceous duct. These typical facial papules are most commonly observed on the , cheeks, and . Dermoscopy enhances diagnostic accuracy as a noninvasive tool, revealing aggregated white-yellowish lobules with a central and a peripheral "crown" of looped telangiectatic vessels that surround but do not cross the central area, aiding differentiation from similar conditions. Biopsy is rarely indicated for straightforward cases, as the diagnosis is primarily clinical, but it may be performed if lesions appear to confirm the presence of enlarged sebaceous lobules connected to a central duct, consisting of mature sebocytes with preserved glandular and typically more than 5 lobules per follicle. A punch is the preferred method when needed, providing histopathological evidence of multiple hyperplastic lobules without malignant features. Magnifying devices such as dermoscopes are routinely employed during examination to visualize subtle vascular and structural details for precise assessment. Additionally, clinical photography is utilized to document lesion morphology, size, and distribution, facilitating monitoring and comparison over time.

Differential Diagnosis

Sebaceous hyperplasia must be differentiated from several benign and malignant conditions that present with similar papular lesions on the face, as accurate identification prevents unnecessary interventions and ensures appropriate management. Key differentials include , which appears as a firmer, solitary pearly nodule with telangiectasias and rolled borders, often lacking the soft, yellowish, umbilicated appearance of multiple lesions in sebaceous hyperplasia. In contrast, trichoepithelioma typically manifests as smaller, symmetrical nodules without a central pore or umbilication, with histological features including basaloid islands, peripheral palisading, and cornified cysts. Other common mimics are senile comedones, which present as open blackheads or comedonal plugs rather than the lobulated, yellowish papules of sebaceous hyperplasia without the characteristic central dell. , representing ectopic sebaceous glands, occur on mucosal surfaces such as the lips or genitals, differing from the facial distribution and non-mucosal involvement in sebaceous hyperplasia. , a viral , produces pearly umbilicated papules with a central core that may express a cheesy material, but it is distinguished by its transmissibility and lack of sebaceous lobules. Sebaceous adenoma presents as a solitary, larger nodule with incomplete sebaceous maturation and possible cystic spaces, unlike the multiple, uniform s of hyperplasia. Nevus sebaceus appears as a congenital, plaque-like with variable epidermal and sebaceous changes, often evolving over time. Distinguishing features of sebaceous hyperplasia include its benign nature, absence of malignant signs such as rapid growth, ulceration, or bleeding, and the ability to express sebum from the central depression upon gentle pressure, which is not observed in mimics like . Dermoscopy can further aid differentiation, revealing crown-like vessels and white-yellowish lobules in sebaceous hyperplasia versus arborizing vessels or blue-gray ovoids in . is recommended if lesions exhibit rapid growth, asymmetry, or other features suggestive of to confirm the through showing enlarged but normal sebaceous glands.

Management

Treatment Options

Sebaceous hyperplasia is a benign condition, and treatment is typically pursued for cosmetic reasons rather than medical necessity. Topical treatments aim to reduce size and include (PDT) using (ALA), which is applied topically followed by light activation to target sebaceous glands. In a study of 10 patients, combination ALA-PDT with pulsed (PDL) resulted in significant clinical improvement compared to PDL alone, with mild transient side effects such as and crusting, though long-term data are limited. (TCA) applied topically can also cause regression but carries risks of discoloration and scarring. Procedural interventions provide more definitive removal for individual lesions. Electrodessication involves intralesional electrical destruction of the gland, effectively eliminating lesions but potentially causing scarring. Laser ablation using (CO2) or pulsed dye lasers targets and vaporizes hyperplastic tissue. According to a survey of dermatologists, CO2 laser treatment typically requires 1 to 2 sessions to achieve lesion clearance, with the number varying based on lesion severity (some cases requiring up to 3-4 sessions, though most resolve with fewer) and is associated with low recurrence rates. For instance, the 1450-nm laser achieved 75% clinical improvement and 50-75% lesion shrinkage in treated cases. freezes and destroys lesions, yielding excellent response rates of 61-71% across patient demographics, though temporary may occur. These methods are suitable for precise removal but require skill to minimize cosmetic defects. For widespread or multiple lesions, oral reduces sebaceous gland size and sebum production. Administered at 1 mg/kg/day for 2 months, it decreased the average number of lesions from 24 to 2 in a cohort of 15 patients, with 100% showing significant improvement and complete resolution in some, though side effects included dryness and transient elevation. Treatment efficacy generally ranges from 70-90% for lesion clearance or improvement across modalities like and lasers, but recurrence is common if the entire sebaceous unit is not eradicated, with rates up to 19% reported for after 2 years. Combination approaches, such as PDT with lasers, often yield higher success rates and better cosmetic outcomes than single modalities, particularly for facial lesions. Emerging treatments as of 2025 include topical rapamycin, which in a retrospective review of six patients achieved improvement with minimal side effects. Single-needle radiofrequency has shown efficacy and safety in treating lesions, while (HIFU) at 20 MHz resulted in complete resolution of 87.9% of lesions in a study, with low risk of side effects. These options offer non-invasive alternatives but require further long-term studies.

Prevention Strategies

Preventing sebaceous hyperplasia focuses on minimizing modifiable risk factors such as (UV) exposure and excessive sebum production, though complete prevention is not always possible due to genetic and age-related influences. Daily application of broad-spectrum with SPF 30 or higher is recommended to reduce UV damage, which acts as a cofactor in the condition's development; additionally, wearing protective clothing like hats and seeking shade during peak sun hours can further limit exposure. A consistent skincare routine plays a key role in lowering , particularly for individuals with oily . Gentle, non-comedogenic cleansers should be used twice daily to remove excess oil without stripping the barrier, while avoiding products that clog pores. Incorporating topical antioxidants, such as serums, may help protect against that contributes to glandular hyperplasia, though evidence is primarily from broader dermatologic studies on . Retinoids (e.g., ) and niacinamide are also beneficial, as they regulate sebum production and prevent glandular clogging, respectively; can reduce dead skin cell buildup to maintain clear pores. Lifestyle modifications, including dietary choices, support overall and may delay onset. A balanced diet low in high-glycemic index foods—such as refined sugars and processed carbohydrates—helps avoid insulin spikes that stimulate activity, based on studies linking to increased sebum production. Regular dermatologic check-ups are advised for at-risk groups, like older adults or those with fair , to monitor for early signs and adjust preventive measures. For individuals on immunosuppressive medications, awareness and monitoring are crucial, as these therapies elevate risk by altering function; consulting a dermatologist for routine exams can facilitate early intervention if lesions appear.

Prognosis and Complications

Prognosis

Sebaceous hyperplasia is a benign, non-progressive condition with an excellent long-term outlook, as the lesions do not evolve into and carry no significant health risks beyond cosmetic concerns. The natural history involves persistent yellowish papules that remain stable over time, often lasting for many years without spontaneous resolution or worsening, though new lesions may develop with advancing age or environmental exposures. Prognosis is influenced by factors such as skin photodamage, with individuals having less sun-exposed or non-sun-damaged skin experiencing fewer new lesions and greater stability compared to those with chronic UV exposure, which can accelerate proliferation. Without intervention, the condition remains stable in the majority of cases, allowing for rather than . Post-treatment outcomes are favorable for cosmetic purposes, with high patient satisfaction following procedures like or electrodessication, which effectively clear lesions. Recurrence of specifically treated lesions is low when the entire sebaceous unit is addressed and underlying contributors such as sun exposure or hormonal imbalances are managed, although new lesions may emerge elsewhere over time. For patients with multiple lesions, regular dermatologic follow-up, including annual skin examinations, is recommended to monitor for any changes and facilitate early intervention if needed.

Complications

Sebaceous hyperplasia is a benign condition with no risk of malignant transformation, though its lesions can sometimes mimic , necessitating for accurate diagnosis. The primary complications arising from the condition itself are cosmetic in nature; the yellowish, umbilicated papules often cause aesthetic concerns, leading to distress and, in some cases, anxiety among affected individuals. Additionally, if lesions are traumatized, there is a rare risk of secondary bacterial , characterized by signs such as redness, swelling, , or fever. In immunosuppressed patients, such as organ transplant recipients on cyclosporine or those with on antiretroviral therapy, sebaceous hyperplasia occurs more frequently and can present in eruptive or widespread forms, potentially increasing the complexity of managing concurrent skin conditions due to overall immune compromise. In these patients, it may also serve as a marker for increased risk of nonmelanoma . Treatment-related complications are more common and include scarring or post-inflammatory pigmentation changes following procedures like laser therapy, electrodesiccation, , or chemical peels, with atrophic scars being permanent and dyspigmentation more pronounced in darker skin types. Oral , while effective for reducing lesion size, carries side effects such as mucocutaneous dryness, , and teratogenicity, making it contraindicated during or in women of childbearing potential without strict contraception protocols. Management of these complications focuses on prevention and supportive care; for instance, post-procedure inflammation can be mitigated with topical corticosteroids, though their use should be cautious in due to potential fetal risks. Early intervention for infections involves antibiotics, and patients are advised to avoid during to prevent teratogenic effects. Overall, the condition has a benign , with complications largely avoidable through careful treatment selection.

References

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  9. https://www.apollohospitals.com/diseases-and-conditions/sebaceous-hyperplasia
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  12. https://www.carydermatology.com/articles/general/920459-sebaceous-hyperplasia/
  13. https://www.jaad.org/article/S0190-9622(09)00680-X/fulltext
  14. https://www.dermatologyadvisor.com/home/decision-support-in-medicine/dermatology/sebaceous-gland-hyperplasia-sebaceous-hyperplasia-senile-sebaceous-hyperplasia/
  15. https://emedicine.medscape.com/article/1059368-clinical
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  17. https://www.sciencedirect.com/topics/medicine-and-dentistry/sebaceous-hyperplasia
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  27. https://pmc.ncbi.nlm.nih.gov/articles/PMC11856972/
  28. https://my.clevelandclinic.org/health/diseases/22670-sebaceous-hyperplasia
  29. https://www.medicalnewstoday.com/articles/321550
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  32. https://www.cureus.com/articles/306612-sebaceous-hyperplasia-of-the-face-a-case-report
  33. https://practicaldermatology.com/news/outstanding-clearance-rates-for-sebaceous-hyperplasia-facial-lesions-seen-with-nps/2459943/
  34. https://www.rupahealth.com/post/sebaceous-hyperplasia-or-something-else-how-to-identify-it
  35. https://emedicine.medscape.com/article/1059368-treatment
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