Talamone (Latin: Telamon, Greek: Τελαμών) is a town in Tuscany, on the west coast of central Italy, administratively a frazione of the comune of Orbetello, province of Grosseto, in the Tuscan Maremma.

Talamone is easily reached from Via Aurelia, and is about 25 kilometres (16 miles) from Grosseto and 10 kilometres (6.2 miles) from Orbetello.

The village lies on a rocky promontory, which lies on the southern border of the Maremma nature reserve, in a dominant position along the whole stretch of coast arriving at Mount Argentario.

The surrounding area is characterized by the presence of vegetation typical of Mediterranean scrub and long sandy beaches, lined by pine trees.

According to Diodorus Siculus, the town was by the Argonauts named after the hero Telamon. However, this etymology is likely a mythological fabrication.

It was an ancient and flourishing city already during the Etruscan period. It was the site of the Battle of Telamon in 225 BC between Roman and the Celtic armies. After the Celts had overrun Etruria and killed 6000 Romans at Faesulae, they were advancing to Rome led by the Gaesatae kings Concolitanus and Aneroëstes. They were met by the Romans near Talamone and were defeated, 40000 celts being killed. The decisive victory removed the Celtic threat from Rome and allowed the Romans to extend their influence over northern Italy.

Talamone was razed to the ground by Sulla for the support that its citizens gave to Marius in his attempt to march against Rome after the return from his African exile.

Trajan (r. 98 to 117 AD) developed the port and had a villa connected to it here, as shown by several finds including a lead pipe stamp found here, now in the Florence archaeological museum.