PDE6

Photoreceptor phosphodiesterase 6 (PDE6 or PDE-6) is a protein complex family, which is highly concentrated in the retina.^[1]^[2]^[3]^[4]

References

^ Cote RH (June 2004). "Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5". International Journal of Impotence Research. 16 (Suppl 1): S28-33. doi:10.1038/sj.ijir.3901212. PMID 15224133. S2CID 9220513.
^ Han J, Dinculescu A, Dai X, Du W, Smith WC, Pang J (December 2013). "Review: the history and role of naturally occurring mouse models with Pde6b mutations". Molecular Vision. 19: 2579–89. PMC 3869645. PMID 24367157.
^ Cote RH (April 2021). "Photoreceptor phosphodiesterase (PDE6): activation and inactivation mechanisms during visual transduction in rods and cones". Pflügers Archiv. 473 (9): 1377–1391. doi:10.1007/s00424-021-02562-x. PMC 8376765. PMID 33860373.
^ Azevedo MF, Faucz FR, Bimpaki E, Horvath A, Levy I, de Alexandre RB, et al. (April 2014). "Clinical and molecular genetics of the phosphodiesterases (PDEs)". Endocrine Reviews. 35 (2): 195–233. doi:10.1210/er.2013-1053. PMC 3963262. PMID 24311737.

[Cote_2004-1] Cote RH (June 2004). "Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5". International Journal of Impotence Research. 16 (Suppl 1): S28-33. doi:10.1038/sj.ijir.3901212. PMID 15224133. S2CID 9220513.

[2] Han J, Dinculescu A, Dai X, Du W, Smith WC, Pang J (December 2013). "Review: the history and role of naturally occurring mouse models with Pde6b mutations". Molecular Vision. 19: 2579–89. PMC 3869645. PMID 24367157.

[3] Cote RH (April 2021). "Photoreceptor phosphodiesterase (PDE6): activation and inactivation mechanisms during visual transduction in rods and cones". Pflügers Archiv. 473 (9): 1377–1391. doi:10.1007/s00424-021-02562-x. PMC 8376765. PMID 33860373.

[4] Azevedo MF, Faucz FR, Bimpaki E, Horvath A, Levy I, de Alexandre RB, et al. (April 2014). "Clinical and molecular genetics of the phosphodiesterases (PDEs)". Endocrine Reviews. 35 (2): 195–233. doi:10.1210/er.2013-1053. PMC 3963262. PMID 24311737.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

PDE6

PDE6

PDE6

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PDE6

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