Self-harm
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| Self-harm | |
|---|---|
| Other names | Deliberate self-harm (DSH), self-injury (SI), nonsuicidal self-injury (NSSI), cutting |
| Healed scars on the forearm from prior self-harm | |
| Specialty | Psychiatry, surgery, or emergency medicine if serious injuries occur |
Self-harm is intentional behavior that causes harm to oneself. This is most commonly regarded as direct injury of one's own tissues, usually without suicidal intention.[1][2][3] Other terms such as cutting, self-abuse, self-injury, and self-mutilation have been used for any self-harming behavior regardless of suicidal intent.[2][4] Common forms of self-harm include damaging the skin with a sharp object or scratching with the fingernails, hitting, or burning. The exact bounds of self-harm are imprecise, but generally exclude tissue damage that occurs as an unintended side-effect of eating disorders or substance abuse, as well as more societally acceptable body modification such as tattoos and piercings.[5]
Although self-harm is by definition non-suicidal, it may still be life-threatening.[6] People who do self-harm are more likely to die by suicide,[3][7] and 40–60% of people who die by suicide have previously self-harmed.[8] Still, only a minority of those who self-harm are suicidal.[9][10]
The desire to self-harm is a common symptom of some personality disorders. People with other mental disorders may also self-harm. Studies also provide strong support for a self-punishment function, and modest evidence for anti-dissociation, interpersonal-influence, anti-suicide, sensation-seeking, and interpersonal boundaries functions.[2] Self-harm can also occur in high-functioning individuals who have no underlying mental health diagnosis. The motivations for self-harm vary; some use it as a coping mechanism to provide temporary relief of intense feelings such as anxiety, depression, stress, emotional numbness, or a sense of failure. Self-harm is often associated with a history of trauma, including emotional and sexual abuse.[11][12] There are a number of different methods that can be used to treat self-harm, which concentrate on either treating the underlying causes, or on treating the behavior itself. Other approaches involve avoidance techniques, which focus on keeping the individual occupied with other activities, or replacing the act of self-harm with safer methods that do not lead to permanent damage.[13]
Self-harm tends to begin in adolescence. Self-harm in childhood is relatively rare, but the rate has been increasing since the 1980s.[14] Self-harm can also occur in the elderly population.[15] The risk of serious injury and suicide is higher in older people who self-harm.[16] Captive animals, such as birds and monkeys, are also known to harm themselves.[17]
History
[edit]This section possibly contains original synthesis. Source material should verifiably mention and relate to the main topic. (August 2023) |




Although the 20th-century psychiatrist Karl Menninger is often credited with the initial clinical characterization of self-harm, self-harm is not a new phenomenon.[18] There is frequent reference in 19th-century clinical literature and asylum records which make a clear clinical distinction between self-harm with and without suicidal intent.[19] This differentiation may have been important to both safeguard the reputations of asylums against accusations of medical neglect and to protect patients and their families from the legal or religious consequences of a suicide attempt.[19] In 1896, the American ophthalmologists George Gould and Walter Pyle categorized self-mutilation cases into three groups: those resulting from "temporary insanity from hallucinations or melancholia; with suicidal intent; and in a religious frenzy or emotion".[20]
Self-harm was, and in some cases continues to be, a ritual practice in many cultures and religions. The Maya priesthood performed auto-sacrifice by cutting and piercing their bodies in order to draw blood.[21] It occurred in ancient Canaanite mourning rituals, as described in the Ras Shamra tablets. Self-harm is practised in Hinduism by the ascetics known as sadhus. In Catholicism, it is known as mortification of the flesh. Some branches of Islam mark the Day of Ashura, the commemoration of the martyrdom of Imam Hussein, with a ritual of self-flagellation, using chains and swords.[22]
Dueling scars such as those acquired through academic fencing at certain traditional German universities are an early example of scarification in European society.[23] Sometimes, students who did not fence would scar themselves with razors in imitation.[23]
Kikuyu girls cut each other's vulvas in the 1950s as a symbol of defiance, in the context of the campaign against female genital mutilation in colonial Kenya. The movement came to be known as Ngaitana ("I will circumcise myself"), because to avoid naming their friends, the girls said they had cut themselves. Historian Lynn Thomas described the episode as significant in the history of FGM because it made clear that its victims were also its perpetrators.[24][25]
Classification
[edit]Karl Menninger considered self-mutilation as a non-fatal expression of an attenuated death wish and thus coined the term partial suicide. He began a classification system of six types:
- neurotic – nail-biters, pickers, extreme hair removal, and unnecessary cosmetic surgery
- religious – self-flagellants and others
- puberty rites – hymen removal, circumcision, or clitoral alteration
- psychotic – eye or ear removal, genital self-mutilation, and extreme amputation
- organic brain diseases – which allow repetitive head-banging, hand-biting, finger-fracturing, or eye removal
- conventional – nail-clipping, trimming of hair, and shaving beards.[26]
Pao differentiated between delicate (low lethality) and coarse (high lethality) self-mutilators who cut. The "delicate" cutters were young, multiple episodic of superficial cuts and generally had borderline personality disorder diagnosis. The "coarse" cutters were older and generally psychotic.[27] Ross and McKay (1979) categorized self-mutilators into nine groups: cutting, biting, abrading, severing, inserting, burning, ingesting or inhaling, hitting, and constricting.[28]
After the 1970s the focus of self-harm shifted from Freudian psycho-sexual drives of the patients.[29]
Walsh and Rosen created four categories numbered by Roman numerals I–IV, defining Self-mutilation as rows II, III and IV.[30]
| Classification | Examples of behavior | Degree of Physical Damage | Psychological State | Social Acceptability |
|---|---|---|---|---|
| I | Ear-piercing, nail-biting, small tattoos, cosmetic surgery (not considered self-harm by the majority of the population) | Superficial to mild | Benign | Mostly accepted |
| II | Piercings, saber scars, ritualistic clan scarring, sailor tattoos, gang tattoos, minor wound-excoriation, trichotillomania | Mild to moderate | Benign to agitated | Subculture acceptance |
| III | Wrist- or body-cutting, self-inflicted cigarette burns and tattoos, major wound-excoriation | Mild to moderate | Psychic crisis | Possibly accepted by a handful of similar-minded friends but not by the general population |
| IV | Auto-castration, self-enucleation, amputation | Severe | Psychotic decompensation | Unacceptable |
Favazza and Rosenthal reviewed hundreds of studies and divided self-mutilation into two categories: culturally sanctioned self-mutilation and deviant self-mutilation.[31] Favazza also created two subcategories of sanctioned self-mutilations; rituals and practices. The rituals are mutilations repeated generationally and "reflect the traditions, symbolism, and beliefs of a society" (p. 226). Practices are historically transient and cosmetic such as piercing of earlobes, nose, eyebrows as well as male circumcision while deviant self-mutilation is equivalent to self-harm.[29][32]
Classification and terminology
[edit]Self-harm (SH), self-injury (SI), nonsuicidal self-injury (NSSI) and self-injurious behavior (SIB) are different terms to describe tissue damage that is performed intentionally and usually without suicidal intent.[33] The adjective "deliberate" is sometimes used, although this has become less common, as some view it as presumptuous or judgmental.[34] Less common or more dated terms include parasuicidal behavior, self-mutilation, self-destructive behavior, self-inflicted violence, self-injurious behavior, and self-abuse.[35] Others use the phrase self-soothing as intentionally positive terminology to counter more negative associations.[36] Self-inflicted wound or self-inflicted injury refers to a broader range of circumstances, including wounds that result from organic brain syndromes, substance abuse, and autoeroticism.[37]
Different sources draw various distinctions between some of these terms. Some sources define self-harm more broadly than self-injury, such as to include drug overdose, eating disorders, and other acts that do not directly lead to visible injuries.[38] Others explicitly exclude these.[34] Some sources, particularly in the United Kingdom, define deliberate self-harm or self-harm in general to include suicidal acts.[39] (This article principally discusses non-suicidal acts of self-inflicted skin damage or self-poisoning.) The inconsistent definitions used for self-harm have made research more difficult.[40]
Nonsuicidal self-injury (NSSI) is listed in Section II (Diagnostic criteria and codes) of the latest, as of April 2025[update], edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) under the category "other conditions that may be a focus of clinical attention".[41] While NSSI is not a separate mental disorder, the DSM-5-TR adds a diagnostic code for the condition in-line with the ICD. The disorder is defined as intentional self-inflicted injury without the intent of dying by suicide. Section III (Emerging measures and models) of the previous edition of the DSM (DSM-5) contains the proposed diagnosis along with criteria and description of Nonsuicidal Self-injury.[42] Criteria for NSSI include five or more days of self-inflicted harm over the course of one year without suicidal intent, and the individual must have been motivated by seeking relief from a negative state, resolving an interpersonal difficulty, or achieving a positive state.[43][42]
A common belief regarding self-harm is that it is an attention-seeking behavior; however, in many cases, this is inaccurate. Many self-harmers are very self-conscious of their wounds and scars and feel guilty about their behavior, leading them to go to great lengths to conceal their behavior from others.[44][45] They may offer alternative explanations for their injuries, or conceal their scars with clothing.[45][46][47] Self-harm in such individuals may not be associated with suicidal or para-suicidal behavior. People who self-harm are not usually seeking to end their own life; it has been suggested instead that they are using self-harm as a coping mechanism to relieve emotional pain or discomfort or as an attempt to communicate distress.[9][10]
Studies of individuals with developmental disabilities (such as intellectual disability) have shown self-harm being dependent on environmental factors such as obtaining attention or escape from demands.[48] Some individuals may have dissociation harboring a desire to feel real or to fit into society's rules.[49]
Signs and symptoms
[edit]The most common form of self-harm for adolescents, according to studies conducted in six countries, is stabbing or cutting the skin with a sharp object.[50] For adults ages 60 and over, self-poisoning (including intentional drug overdose) is by far the most common form.[51] Other self-harm methods include burning, head-banging, biting, scratching, hitting, preventing wounds from healing, self-embedding of objects, and hair-pulling.[52] The locations of self-harm are often areas of the body that are easily hidden and concealed from the sight of others, most commonly being the forearms, thighs or torso.[53]
Causes
[edit]Mental disorder
[edit]Although some people who self-harm do not have any form of recognized mental disorder,[54] self-harm often co-occurs with psychiatric conditions. Self-harm is, for example, associated with eating disorders,[55] autism,[56][57] borderline personality disorder, dissociative disorders, bipolar disorder,[58] depression,[11][59] phobias,[11] and conduct disorders.[60] As many as 70% of individuals with borderline personality disorder engage in self-harm.[61] An estimated 30% of autistic individuals engage in self-harm at some point, including eye-poking, skin-picking, hand-biting, and head-banging.[56][57] According to a meta-analysis that did not distinguish between suicidal and non-suicidal acts, self-harm is common among those with schizophrenia and is a significant predictor of suicide.[62] There are parallels between self-harm and factitious disorder, a psychiatric disorder in which individuals feign illness or trauma.[63] There may be a common ground of inner distress culminating in self-directed harm in patients with this condition. However, a desire to deceive medical personnel in order to gain treatment and attention is more important in factitious disorder than in self-harm.[63]
Psychological factors
[edit]Self-harm is frequently described as an experience of depersonalization or a dissociative state.[64] Abuse during childhood is accepted as a primary social factor increasing the incidence of self-harm,[65] as is bereavement,[66] and troubled parental or partner relationships.[9][12] Factors such as war, poverty, unemployment, and substance abuse may also contribute.[9][11][67][68] Other predictors of self-harm and suicidal behavior include feelings of entrapment, defeat, lack of belonging, and perceiving oneself as a burden along with having an impulsive personality and/or less effective social problem-solving skills.[9][69][page needed] Two studies have indicated that self-harm correlates more with pubertal phase, particularly the end of puberty (peaking around 15 for girls), rather than with age. Adolescents may be more vulnerable neurodevelopmentally in this time, and more vulnerable to social pressures, with depression, alcohol abuse, and sexual activity as independent contributing factors.[70] Transgender adolescents are significantly more likely to engage in self-harm than their cisgender peers.[71][72] This can be attributed to distress caused by gender dysphoria as well as increased likelihoods of experiencing bullying, abuse, and mental illness.[72][73]
Genetics
[edit]The most distinctive characteristic of the rare genetic condition Lesch–Nyhan syndrome is uncontrollable self-harm and self-mutilation, and may include biting (particularly of the skin, nails, and lips)[74] and head-banging.[75] Genetics may contribute to the risk of developing other psychological conditions, such as anxiety or depression, which could in turn lead to self-harming behavior. However, the link between genetics and self-harm in otherwise healthy patients is largely inconclusive.[7]
Drugs and alcohol
[edit]Substance misuse, dependence and withdrawal are associated with self-harm. Benzodiazepine dependence as well as benzodiazepine withdrawal is associated with self-harming behavior in young people.[76] Alcohol is a major risk factor for self-harm.[77] A study which analyzed self-harm presentations to emergency rooms in Northern Ireland found that alcohol was a major contributing factor and involved in 63.8% of self-harm presentations.[78] A 2009 study in the relation between cannabis use and deliberate self-harm (DSH) in Norway and England found that, in general, cannabis use may not be a specific risk factor for DSH in young adolescents.[79] Smoking has also been associated with both non-suicidal self injury and suicide attempts in adolescents, although the nature of the relationship is unclear.[80] A 2021 meta-analysis on literature concerning the association between cannabis use and self-injurious behaviors has defined the extent of this association, which is significant both at the cross-sectional (odds ratio = 1.569, 95% confidence interval [1.167-2.108]) and longitudinal (odds ratio = 2.569, 95% confidence interval [2.207-3.256]) levels, and highlighting the role of the chronic use of the substance, and the presence of depressive symptoms or of mental disorders as factors that might increase the risk of self-injury among cannabis users.[81]
Pathophysiology
[edit]
Self-injury may result in serious injury and scarring. While non-suicidal self-injury by definition lacks suicidal intent, it may nonetheless result in accidental death.[82]
While the motivations for self harm vary, the most commonly endorsed reason for self harm given by adolescents is to get relief from a terrible state of mind.[83][84] Young people with a history of repeated episodes of self harm are more likely to self-harm into adulthood,[85][86] and are at higher risk of suicide.[87] In older adults, influenced by a combination of interconnected individual, societal, and healthcare factors, including financial and interpersonal problems and comorbid physical conditions and pain, with increased loneliness, perceived burdensomeness of ageing, and loss of control reported as particular motivations.[84] There is a positive statistical correlation between self-harm and physical, sexual, and emotional abuse.[11]: 63 [12][better source needed] Self-harm may become a means of managing and controlling pain, in contrast to the pain experienced earlier in the person's life over which they had no control (e.g., through abuse).[88][medical citation needed]
Assessment of motives in a medical setting is usually based on precursors to the incident, circumstances, and information from the patient.[9] However, limited studies show that professional assessments tend to suggest more manipulative or punitive motives than the patient's own statements.[89]
A UK Office for National Statistics study reported only two motives: "to draw attention" and "because of anger".[11] For some people, harming themselves can be a means of drawing attention to the need for help and to ask for assistance in an indirect way. It may also be an attempt to affect others and to manipulate them in some way emotionally.[90][88][medical citation needed] However, those with chronic, repetitive self-harm often do not want attention and hide their scars carefully.[91][medical citation needed]
Many people who self-harm state that it allows them to "go away" or dissociate, separating the mind from feelings that are causing anguish. This may be achieved by tricking the mind into believing that the present suffering being felt is caused by the self-harm instead of the issues they were facing previously: the physical pain therefore acts as a distraction from the original emotional pain.[46][medical citation needed] To complement this theory, one can consider the need to "stop" feeling emotional pain and mental agitation.[92][medical citation needed]
Alternatively, self-harm may be a means of feeling something, even if the sensation is unpleasant and painful. Those who self-harm sometimes describe feelings of emptiness or numbness (anhedonia), and physical pain may be a relief from these feelings.[92][medical citation needed]
Those who engage in self-harm face the contradictory reality of harming themselves while at the same time obtaining relief from this act. It may even be hard for some to actually initiate cutting, but they often do because they know the relief that will follow. For some self-harmers this relief is primarily psychological while for others this feeling of relief comes from the beta endorphins released in the brain.[90][medical citation needed] Endorphins are endogenous opioids that are released in response to physical injury, acting as natural painkillers and inducing pleasant feelings, and in response to self-harm would act to reduce tension and emotional distress.[2] Many people do not feel physical pain when self-harming.[93] Studies of clinical and non-clinical populations suggest that people who engage in self-harm have higher pain thresholds and tolerance in general, although a 2016 review characterized the evidence base as "greatly limited". There is no consensus as to the reason for this apparent phenomenon.[94]
As a coping mechanism, self-harm can become psychologically addictive because, to the self-harmer, it works; it enables them to deal with intense stress in the current moment. The patterns sometimes created by it, such as specific time intervals between acts of self-harm, can also create a behavioral pattern that can result in a wanting or craving to fulfill thoughts of self-harm.[95]
Autonomic nervous system
[edit]Emotional pain activates the same regions of the brain as physical pain,[96] so emotional stress can be a significantly intolerable state for some people. Some of this is environmental and some of this is due to physiological differences in responding.[97] The autonomic nervous system is composed of two components: the sympathetic nervous system controls arousal and physical activation (e.g., the fight-or-flight response) and the parasympathetic nervous system controls physical processes that are automatic (e.g., saliva production). The sympathetic nervous system innervates (e.g., is physically connected to and regulates) many parts of the body involved in stress responses. Studies of adolescents have shown that adolescents who self-injure have greater physiological reactivity (e.g., skin conductance) to stress than adolescents who do not self-injure.[98][99]
Treatment
[edit]Several forms of psychosocial treatments can be used in self-harm including dialectical behavior therapy.[100] Psychiatric and personality disorders are common in individuals who self-harm and as a result self-harm may be an indicator of depression and/or other psychological problems.[101] As of 2021[update], there is little or no evidence that antidepressants, mood stabilizers, or dietary supplements reduce repetition of self-harm. In limited research into antipsychotics, one small trial of flupentixol found a possible reduction in repetition, while one small trial of fluphenazine found no difference between low and ultra-low doses.[102] As of 2012[update], no clinical trials have evaluated the effects of pharmacotherapy on adolescents who self-harm.[103]
Emergency departments are often the first point of contact with healthcare for people who self-harm. As such they are crucial in supporting them and can play a role in preventing suicide. At the same time, according to a study conducted in England, people who self-harm often experience that they do not receive meaningful care at the emergency department. Both people who self-harm and staff in the study highlighted the failure of the healthcare system to support, the lack of specialist care. People who self-harm in the study often felt shame or being judged due to their condition, and said that being listened to and validated gave them hope. At the same time staff experienced frustration from being powerless to help and were afraid of being blamed if someone died by suicide. [104]
There are also difficulties in meeting the need of patients that self-harm in mental healthcare. Studies have shown that staff found the care for people who self-harm emotionally challenging and they experienced an overwhelming responsibility in preventing the patients from self-harming[105] and the care focuses mainly on maintaining the safety for the patients, for example by removing dangerous items or physical restraint, even if it is believed to be ineffective.[106] A French ethnographic study has found out that regular staff meeting for caregivers but also for parents dealing with adolescents who self-harm were especially efficient to diminish guilt and powerless feelings[107], as well as violent reactions denounced by those who self-harm.[108] The possibility to regularly share the emotions raised by taking care of people who self-harm make it possible to move from personal and distressing self-questioning ("am I a good carer?") to professional and supportive reflection ("what makes a good carer?").
Therapy
[edit]A meta-analysis from Cochrane in 2016 found low-quality evidence suggesting that CBT-based psychotherapy can reduce the number of adults repeating self-harm. For those with repeated self-harm or probable personality disorder, group-based emotion-regulation psychotherapy, mentalization, and DBT showed promise in reducing repetition or frequency of self-harm, though the evidence quality varied from low to moderate.[109] This meta-analysis was repeated again in 2021, and found uncertain evidence for many psychosocial interventions in reducing self-harm repetition in adults, noting significant methodological limitations across studies. While CBT-based therapies might reduce repetition at longer follow-ups (however with low certainty of evidence), MBT and group-based emotion regulation therapy showed promise in single or related trials, warranting further research.[110]
Dialectical behavior therapy for adolescents (DBT-A) is a well-established treatment for self-injurious behavior in youth and is probably useful for decreasing the risk of non-suicidal self-injury.[100][111] Several other treatments including integrated CBT (I-CBT), attachment-based family therapy (ABFT), resourceful adolescent parent program (RAP-P), intensive interpersonal psychotherapy for adolescents (IPT-A-IN), mentalization-based treatment for adolescents (MBT-A), and integrated family therapy are probably efficacious.[100][112] Cognitive behavioral therapy may also be used to assist those with Axis I diagnoses, such as depression, schizophrenia, and bipolar disorder. Dialectical behavior therapy (DBT) can be successful for those individuals exhibiting a personality disorder, and could potentially be used for those with other mental disorders who exhibit self-harming behavior.[112] Diagnosis and treatment of the causes of self-harm is thought by many to be the best approach to treating self-harm.[10] In adolescents multisystem therapy shows promise.[113] According to the classification of Walsh and Rosen[30] trichotillomania and nail biting represent class I and II self-mutilation behavior (see classification section in this article); for these conditions habit reversal training and decoupling have been found effective according to meta-analytic evidence.[114]
A meta-analysis found that psychological therapy is effective in reducing self-harm. The proportion of the adolescents who self-harmed over the follow-up period was lower in the intervention groups (28%) than in controls (33%). Psychological therapies with the largest effect sizes were dialectical behavior therapy (DBT), cognitive-behavioral therapy (CBT), and mentalization-based therapy (MBT).[115]
Avoidance techniques
[edit]Generating alternative behaviors that the person can engage in instead of self-harm is one successful behavioral method that is employed to avoid self-harm.[116] Techniques, aimed at keeping busy, may include journaling, taking a walk, participating in sports or exercise or being around friends when the person has the urge to harm themselves.[13] The removal of objects used for self-harm from easy reach is also helpful for resisting self-harming urges.[13] The provision of a card that allows the person to make emergency contact with counselling services should the urge to self-harm arise may also help prevent the act of self-harm.[117] Some providers may recommend harm-reduction techniques such as snapping of a rubber band on the wrist,[118] but there is no consensus as to the efficacy of this approach.[119]
Epidemiology
[edit]

It is difficult to gain an accurate picture of incidence and prevalence of self-harm.[120] Even with sufficient monitoring resources, self-harm is usually unreported, with instances taking place in private and wounds being treated by the self-harming individual.[121] Recorded figures can be based on three sources: psychiatric samples, hospital admissions and general population surveys.[122] A 2015 meta-analysis of reported self-harm among 600,000 adolescents found a lifetime prevalence of 11.4% for suicidal or non-suicidal self-harm (i.e. excluding self-poisoning) and 22.9% for non-suicidal self-injury (i.e. excluding suicidal acts), for an overall prevalence of 16.9%.[123] The difference in SH and NSSI rates, compared to figures of 16.1% and 18.0% found in a 2012 review, may be attributable to differences in methodology among the studies analyzed.[124]
The World Health Organization estimates that, as of 2010, 880,000 deaths occur as a result of self-harm (including suicides).[125] About 10% of admissions to medical wards in the UK are as a result of self-harm, the majority of which are drug overdoses.[66] However, studies based only on hospital admissions may hide the larger group of self-harmers who do not need or seek hospital treatment for their injuries,[9] instead treating themselves. Many adolescents who present to general hospitals with deliberate self-harm report previous episodes for which they did not receive medical attention.[122] In the United States up to 4% of adults self-harm with approximately 1% of the population engaging in chronic or severe self-harm.[126]
The onset of self-harm tends to occur around puberty, although scholarship is divided as to whether this is usually before puberty or later in adolescence. Meta-analyses have not supported some studies' conclusion that self-harm rates are increasing among adolescents. It is generally thought that self-harm rates increase over the course of adolescence, although this has not been studied thoroughly.[127] The earliest reported incidents of self-harm are in children between 5 and 7 years old.[44] In addition there appears to be an increased risk of self-harm in college students than among the general population.[77][page needed][126] In a study of undergraduate students in the US, 9.8% of the students surveyed indicated that they had purposefully cut or burned themselves on at least one occasion in the past. When the definition of self-harm was expanded to include head-banging, scratching oneself, and hitting oneself along with cutting and burning, 32% of the sample said they had done this.[128] In Ireland, a study found that instances of hospital-treated self-harm were much higher in city and urban districts, than in rural settings.[129] The CASE (Child & Adolescent Self-harm in Europe) study suggests that the life-time risk of self-injury is ~1:7 for women and ~1:25 for men.[130]
Gender differences
[edit]Aggregated research has found no difference in the prevalence of self-harm between men and women.[126] This contrasts with previous studies, which suggested that up to four times as many females as males have direct experience of self-harm,[9] which many had argued was rather the result of data collection biases.[131]
The WHO/EURO Multicentre Study of Suicide, established in 1989, demonstrated that, for each age group, the female rate of self-harm exceeded that of the males, with the highest rate among females in the 13–24 age group and the highest rate among males in the 12–34 age group. However, this discrepancy has been known to vary significantly depending upon population and methodological criteria, consistent with wide-ranging uncertainties in gathering and interpreting data regarding rates of self-harm in general.[132] Such problems have sometimes been the focus of criticism in the context of broader psychosocial interpretation. For example, feminist author Barbara Brickman has speculated that reported gender differences in rates of self-harm are due to deliberate socially biased methodological and sampling errors, directly blaming medical discourse for pathologising the female.[133] Analyzing 70 most-cited articles in the psychiatrists and psychoanalytics journals in 2020, the psychologist Adrien Cascarino found out that one of the reason for this bias was the belief that most of the people self-harm because they have been sexually abused during their childhood (and were therefore mostly women),[107] while this belief has been proven wrong by a meta-analysis.[134]
This gender discrepancy is often distorted in specific populations where rates of self-harm are inordinately high, which may have implications on the significance and interpretation of psychosocial factors other than gender. A study in 2003 found an extremely high prevalence of self-harm among 428 homeless and runaway youths (aged 16–19) with 72% of males and 66% of females reporting a history of self-harm.[135] However, in 2008, a study of young people and self-harm saw the gender gap widen in the opposite direction, with 32% of young females, and 22% of young males admitting to self-harm.[136] Studies also indicate that males who self-harm may also be at a greater risk of completing suicide.[8]
There does not appear to be a difference in motivation for self-harm in adolescent males and females. Triggering factors such as low self-esteem and having friends and family members who self-harm are also common between both males and females.[122] One limited study found that, among those young individuals who do self-harm, both genders are just as equally likely to use the method of skin-cutting.[137] However, females who self-cut are more likely than males to explain their self-harm episode by saying that they had wanted to punish themselves. In New Zealand, more females are hospitalized for intentional self-harm than males. Females more commonly choose methods such as self-poisoning that generally are not fatal, but still serious enough to require hospitalization.[138]
Elderly
[edit]In a study of a district general hospital in the UK, 5.4% of all the hospital's self-harm cases were aged over 65. The male to female ratio was 2:3, although the self-harm rates for males and females over 65 in the local population were identical. Over 90% had depressive conditions, and 63% had significant physical illness. Under 10% of the patients gave a prior history of earlier self-harm, while both the repetition and suicide rates were very low, which could be explained by the absence of factors known to be associated with repetition, such as personality disorder and alcohol abuse.[15] However, NICE Guidance on Self-harm in the UK suggests that older people who self-harm are at a greater risk of completing suicide, with 1 in 5 older people who self-harm going on to end their life.[16] A study completed in Ireland showed that older Irish adults have high rates of deliberate self-harm, but comparatively low rates of suicide.[129]
Developing world
[edit]Only recently have attempts to improve health in the developing world concentrated on not only physical illness but also mental health.[139] Deliberate self-harm is common in the developing world. Research into self-harm in these areas is however, still very limited. Though an important case study is that of Sri Lanka, which is a country exhibiting a high incidence of suicide[140] and self-poisoning with agricultural pesticides or natural poisons.[139] Many people admitted for deliberate self-poisoning during a study by Eddleston et al.[139] were young and few expressed a desire to die, but death was relatively common in the young in these cases. The improvement of medical management of acute poisoning in the developing world is poor and improvements are required in order to reduce mortality.
Some of the causes of deliberate self-poisoning in Sri Lankan adolescents included bereavement and harsh discipline by parents. The coping mechanisms are being spread in local communities as people are surrounded by others who have previously deliberately harmed themselves or attempted suicide.[139] One way to reduce self-harm would be to limit access to poisons; however many cases involve pesticides or yellow oleander seeds, and the reduction of access to these agents would be difficult. Great potential for the reduction of self-harm lies in education and prevention, but limited resources in the developing world ultimately make these methods challenging.[139]
Prison inmates
[edit]Deliberate self-harm is especially prevalent in prison populations. A proposed explanation for this is that prisons are often violent places, and prisoners who wish to avoid physical confrontations may resort to self-harm as a ruse, either to convince other prisoners that they are dangerously insane and resilient to pain or to obtain protection from the prison authorities.[141] Prisoners are sometimes placed in cells with no furniture or objects to prevent them from harming themselves.[142] Self-harm also occurs frequently in inmates who are placed in solitary confinement.[143]
Awareness
[edit]There are many movements among the general self-harm community to make self-harm itself and treatment better known to mental health professionals, as well as the general public. For example, March 1 is designated as Self-injury Awareness Day (SIAD) around the world.[144] On this day, some people choose to be more open about their own self-harm, and awareness organizations make special efforts to raise awareness about self-harm.[145]
Other animals
[edit]Self-harm in non-human mammals is a well-established but not widely known phenomenon. Its study under zoo or laboratory conditions could lead to a better understanding of self-harm in human patients.[17]
Zoo or laboratory rearing and isolation are important factors leading to increased susceptibility to self-harm in higher mammals, e.g., macaque monkeys.[17] Non-primate mammals are also known to mutilate themselves under laboratory conditions after administration of drugs.[17] For example, pemoline, clonidine, amphetamine, and very high (toxic) doses of caffeine or theophylline are known to precipitate self-harm in lab animals.[146][147]
In dogs, canine obsessive-compulsive disorder can lead to self-inflicted injuries, for example canine lick granuloma. Captive birds are sometimes known to engage in feather-plucking, causing damage to feathers that can range from feather shredding to the removal of most or all feathers within the bird's reach, or even the mutilation of skin or muscle tissue.[148]
Breeders of show mice have noticed similar behaviors. One known as "barbering" involves a mouse obsessively grooming the whiskers and facial fur off themselves and cage-mates.[149]
-
Lick granuloma from excessive licking
See also
[edit]References
[edit]Citations
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- "There was no evidence of an effect on repetition of SH by post‐intervention for low‐dose fluphenazine in this trial (12⁄27 versus 9⁄26; OR 1.51, 95% CI 0.50 to 4.58; N=53; k=1; I2=not applicable). According to GRADE criteria, we judged the evidence to be of low certainty" (p. 20).
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External links
[edit]Self-harm
View on GrokipediaDefinition and Classification
Core Definition and Distinctions
Self-harm, commonly termed non-suicidal self-injury (NSSI), constitutes the deliberate, direct destruction of one's own body tissue without suicidal intent and for purposes not socially or culturally sanctioned, such as cutting, burning, or scratching to draw blood or alter appearance.[4][13] This behavior typically involves immediate physical damage, distinguishing it from indirect self-destructive actions like excessive substance use or reckless driving, which lack the acute, targeted tissue harm.[14] A primary distinction lies in the absence of lethal intent, separating NSSI from suicidal behavior; whereas suicidal acts involve a sequence of self-initiated actions believed to cause death, NSSI aims at emotional regulation, pain relief, or interpersonal influence without endangering life overall.[15][16] Empirical studies confirm this intent-based differentiation, noting that NSSI often produces superficial wounds insufficient for lethality, though escalation risks exist if untreated.[17] In diagnostic frameworks like DSM-5, NSSI disorder requires recurrent incidents (five or more days in the past year) causing tissue damage likely to induce injury, excluding acts for sexual gratification, peer conformity, or medical deception, such as in factitious disorder.[18][19] Further distinctions exclude culturally normative practices, like ritual scarring in certain indigenous groups or body piercings, which serve symbolic or aesthetic roles without the intrapersonal distress characteristic of NSSI.[20] NSSI also differs from stereotypic self-injurious behaviors in neurodevelopmental disorders (e.g., head-banging in autism), which are repetitive and non-volitional rather than purposive for affect modulation.[21] These boundaries underscore NSSI's focus on intentional, non-lethal self-trauma driven by psychological functions, as evidenced in longitudinal data tracking intent via self-reports and clinical assessments.[22]Types and Common Methods
Cutting, particularly of the skin on the forearms, thighs, or other accessible areas, represents the most prevalent method of nonsuicidal self-injury (NSSI), with studies reporting engagement rates of 70-90% among those who self-harm without suicidal intent.[23] [13] This method involves using sharp objects such as razors, knives, or glass to inflict superficial to moderate wounds, often resulting in linear scars.[4] Other common NSSI behaviors include severe scratching or scraping of the skin, reported in 60-70% of cases, and burning with cigarettes, lighters, or heated objects, affecting 20-40% of individuals.[19] Hitting or punching oneself, head-banging against surfaces, or bruising via interference with wound healing (e.g., picking at scabs) each occur in 20-45% of NSSI episodes, varying by population and study.[24] [25] In particular, hitting oneself on the head during periods of strong stress, sometimes associated with psychogenic pruritus (stress-induced itching), constitutes a form of self-injurious behavior frequently employed to cope with intense emotions, anxiety, or frustration.[26] [27] Less frequent but documented methods encompass hair-pulling (trichotillomania-like), biting, pinching, or inserting objects into the skin, with prevalence under 15% in adolescent and young adult samples.[24] [25] These behaviors are distinguished from suicidal acts by their lower lethality and absence of intent to die, though overlap can occur in comorbid cases.[4] In the DSM-5 classification, NSSI is characterized by at least five days of such intentional tissue damage in the past year, excluding culturally sanctioned practices like ritual scarring.[17]Terminology in Online Communities
In online communities and forums where individuals discuss non-suicidal self-injury (NSSI), specific slang terms are commonly used to describe the depth and appearance of injuries, particularly from cutting.- Cat scratches: Refers to very superficial cuts or scratches limited to the epidermis (outer skin layer). These appear as thin red lines or marks, often with minimal bleeding and quick scabbing. They are considered the mildest form in this informal classification.
- Styros (or "styro"): Short for "Styrofoam," describing cuts that reach the dermis (second skin layer). The exposed dermal tissue appears white, shiny, or foamy, resembling Styrofoam. These are deeper than cat scratches, typically involve more bleeding, slower healing, and greater scarring risk.
Diagnostic Criteria and Terminology
Non-suicidal self-injury (NSSI) refers to the deliberate, direct destruction or alteration of one's body tissue without suicidal intent and for purposes not socially or culturally sanctioned.[17] This terminology distinguishes NSSI from suicidal behavior, where the primary aim is death, and from culturally normative practices such as ritual piercings or tattoos.[28] Other terms include self-harm (SH), often used broadly in clinical and epidemiological contexts, and deliberate self-harm (DSH), which in some regions like the UK may encompass acts with ambiguous or mixed intent.[21] Self-injurious behavior (SIB) is a more general descriptor applied across populations, including those with intellectual disabilities, but lacks the specificity of NSSI regarding intent.[29] In the DSM-5, NSSI is classified as a condition for further study under "Non-Suicidal Self-Injury Disorder" (NSSID), with proposed diagnostic criteria requiring: (A) engagement in NSSI via methods like cutting or burning on at least five days in the past year; (B) performance of NSSI to achieve relief from negative affect, resolve interpersonal issues, or generate a positive emotional response; (C) presence of clinically significant preoccupation with or urges toward NSSI; (D) resultant distress or impairment in social, occupational, or other functioning; (E) exclusion of better explanations by other disorders, substances, or medical conditions; and (F) deliberate consideration of the act's tissue-damaging potential.[17] [18] These criteria emphasize frequency, function, and impact, reflecting empirical evidence that NSSI often serves emotion regulation rather than lethality. Specifically, the functions in criterion (B) commonly manifest as individuals engaging in self-harm, such as cutting, primarily to cope with intense emotional distress; cutting often provides temporary relief by substituting physical pain for overwhelming emotional pain or by breaking through emotional numbness, allowing individuals to feel something when they feel empty, detached, or numb.[17] The DSM-5-TR introduced specific V-codes for NSSI as a standalone specifier, facilitating clinical tracking without full diagnostic status.[30] The ICD-11 does not define NSSI or NSSID as a distinct psychiatric disorder but codes intentional self-harm under external causes (e.g., XS00-XS0Z for unspecified or mechanism-specific acts like cutting or poisoning), with intent qualifiers distinguishing non-suicidal from suicidal motivations.[31] This approach prioritizes injury description and context over behavioral diagnosis, allowing linkage to underlying conditions like borderline personality disorder or depression, where self-harm may manifest as a symptom.[32] Diagnostic assessments typically involve structured interviews evaluating intent, frequency, methods, and exclusion of alternatives, with tools like the Clinician-Administered NSSI Disorder Index demonstrating reliability in validating NSSID criteria.[19] Comorbidities must be ruled out, as NSSI frequently co-occurs with mood, anxiety, or trauma-related disorders but requires independent clinical significance for separate consideration.[33]Prevalence and Epidemiology
Global and Historical Trends
Instances of self-harm have been documented throughout history, often in ritualistic or religious contexts such as flagellation during medieval Christian processions or self-mutilation in certain ascetic traditions, though these differed motivationally from modern non-suicidal self-injury (NSSI). The psychiatric conceptualization of NSSI—deliberate tissue damage without suicidal intent, typically for intrapersonal regulation—emerged in the early 20th century, with initial clinical descriptions appearing in the medical literature by the 1930s. Reported cases remained sporadic and often conflated with suicidal behavior until the late 20th century, when NSSI gained distinct recognition amid rising adolescent presentations in clinical settings from the 1960s onward, accelerating in the 1980s with expanded research and diagnostic attention.[34][23][13] Global lifetime prevalence of NSSI in community samples of adolescents and young adults hovers between 17% and 22%, derived from meta-analyses aggregating data from diverse countries. A 2022 meta-analysis encompassing 686,672 participants estimated 22.1% lifetime prevalence (95% CI: 16.9–28.4%), with 19.5% for past-year engagement. Pooled estimates across 17 nations yield 17.7%, exhibiting female predominance (female-to-male odds ratio 1.60; 95% CI: 1.29–1.98). These figures vary by region, with higher rates in high-socio-demographic index areas, though underreporting persists in low-resource settings due to cultural stigma and limited surveillance.[24][35][36] Temporal trends indicate a marked upsurge in NSSI since the 1990s, attributable in part to genuine incidence growth alongside improved detection. In the United States, emergency department visits for nonfatal self-inflicted injuries among ages 10–24 rose sharply, with rates for females increasing over 50% from 2009 to 2015. Globally, incident self-harm cases among children and adolescents totaled 5.49 million in 2021, with forecasts projecting 10.55 million by 2040 amid fluctuating prevalence in high-income regions from 1990–2021. This trajectory aligns with stabilized or modestly rising patterns in sexual minority youth (38–53% prevalence) versus heterosexual peers (11–20%) over 2005–2017, underscoring persistent vulnerabilities despite diagnostic refinements.[37][38][39]Demographic Patterns
Self-harm, particularly non-suicidal self-injury (NSSI), exhibits marked gender disparities, with females consistently reporting higher lifetime prevalence rates than males across multiple epidemiological studies. A 2024 meta-analysis of 38 studies encompassing 266,491 adolescents found NSSI prevalence to be approximately twice as high among females compared to males, particularly in North American samples, though this ratio was less pronounced or absent in some Asian cohorts.[35] Similarly, a systematic review of adolescent self-harm prevalence reported rates of 19.4% for females versus 12.9% for males, attributing the difference partly to greater female endorsement of repetitive, less severe methods like cutting.[36] These patterns hold in community samples but may reverse for hospital presentations involving more lethal methods, where males predominate due to preferences for higher-risk behaviors.[40] Age patterns reveal a peak incidence during adolescence and early adulthood, with the average age of onset around 13 years and prevalence escalating through the mid-teens before declining in later adulthood. In youth cohorts, NSSI rates increase from 4-7.6% in elementary school-aged children to 8-15% by age 14-19, driven by developmental vulnerabilities such as emotional dysregulation and peer influences.[1] [41] Among adults, rates diminish post-25, though midlife women (aged 40-59) show elevated hospital presentation rates of 449 per 100,000, often linked to cumulative stressors rather than the impulsive NSSI typical of youth.[42] Lifetime prevalence stabilizes at 17% across populations, underscoring adolescence as the critical risk window.[43] Ethnic and racial variations indicate higher self-harm rates among White populations compared to ethnic minorities in Western contexts. In UK pediatric emergency data, annual self-harm rates per 100,000 were 574 for White children and adolescents, versus 225 for Black, 260 for South Asian, and 344 for other non-White groups, with steeper increases over time among Whites.[44] US community studies corroborate this, identifying non-Hispanic White ethnicity as a demographic correlate of NSSI, potentially reflecting cultural differences in expression or reporting biases in understudied minority groups.[45] Conversely, some global adolescent data show no uniform ethnic gradient, suggesting contextual factors like acculturation stress may elevate risks in specific immigrant subgroups.[38] Socioeconomic status inversely correlates with self-harm incidence, with lower parental or area-level deprivation strongly associated with elevated rates, especially among adolescent females. A longitudinal study found low socioeconomic position doubled self-harm odds in girls but not boys, mediated by factors like family discord and limited access to coping resources.[46] Hospital data from deprived areas reveal over-representation of self-harm cases, with males and non-White individuals disproportionately affected in the lowest quintiles, highlighting compounded vulnerabilities from economic hardship.[47] These patterns persist after adjusting for comorbidities, implying direct causal links via material insecurity and psychosocial strain.[48]Recent Developments and Variations
During the COVID-19 pandemic, self-harm presentations and prevalence increased globally, with emergency department visits for self-harm among U.S. youth and young adults reaching an estimated 224,341 in 2020, particularly elevated among girls whose rates doubled compared to boys.[49] This trend aligned with heightened suicidal ideation and attempts in adolescents, varying from 7.9% to 39.6% for ideation and 1.8% to 18.3% for attempts across countries, peaking around 2021 before partial declines.[50] Non-suicidal self-injury (NSSI) rates among youth similarly rose, with probabilities highest in 2022 and sustained elevations into 2023 relative to pre-pandemic baselines.[51] Post-2023, some regions observed decreases in overall self-harm incidence among children and young people, though age-specific variations emerged, including sharp rises in 10-12-year-olds that outpaced older groups.[52] Globally, adolescent self-harm prevalence showed a downward trajectory from 1990 to 2021 per age-standardized metrics, yet disability-adjusted life years (DALYs) from self-harm indicated higher burdens in males (562.6 per 100,000) than females (259.1 per 100,000) in 2021, reflecting sex differences in lethality rather than incidence.[38][53] Ethnic disparities in youth self-harm rates persisted, with annual incidences per 100,000 at 574 for White children, 225 for Black, 260 for South Asian, and 344 for other non-White groups in recent U.K. data.[44] Emerging NSSI epidemiology highlights lifetime prevalence of 17-25% in community adolescents, with females at greater risk, though clinical treatment-seeking samples report up to 84% monthly engagement.[54][55] Projections estimate self-inflicted deaths rising from 746,388 in 2021 to 877,491 by 2050, underscoring ongoing epidemiological shifts amid socioeconomic and mental health pressures.[53]Risk Factors and Etiology
Psychological and Developmental Contributors
Emotion dysregulation, characterized by difficulties in identifying, accepting, and modulating emotional responses, is a core psychological contributor to non-suicidal self-injury (NSSI), with meta-analytic evidence indicating a robust association across diverse populations and settings.[56] Individuals engaging in self-harm often report using it as a maladaptive strategy to regulate overwhelming negative affect, such as intense anger or distress, rather than as a deliberate suicidal act.[13] This link holds longitudinally, where baseline emotion dysregulation predicts future NSSI onset and persistence, independent of age or clinical status.[56] Comorbid mental disorders, particularly mood and personality disorders, elevate self-harm risk through intertwined mechanisms of affective instability and cognitive distortions. Depression and borderline personality disorder features show strong prospective associations with NSSI repetition, with odds ratios exceeding 2-3 in systematic reviews of adolescents.[57] [58] Impulsivity, often measured via trait scales or behavioral tasks, further mediates this pathway, correlating with higher NSSI frequency in both cross-sectional and longitudinal adolescent cohorts.[59] [58] These factors cluster in individuals with externalizing symptoms like aggression, underscoring a profile of poor inhibitory control rather than isolated internal distress.[58] Attention-deficit/hyperactivity disorder (ADHD) is a significant psychological and developmental risk factor for self-harm behaviors, particularly in children and adolescents. Children with ADHD are at significantly higher risk of self-harm behaviors compared to their peers, with longitudinal evidence showing substantially elevated odds (e.g., over 20 times higher risk of self-harm by mid-adolescence).[60] Key reasons include emotional dysregulation (difficulty managing intense emotions like anxiety, sadness, or frustration), impulsivity (a core ADHD symptom leading to acting on harmful urges), and using self-harm as a maladaptive coping mechanism to regulate overwhelming feelings, regain control, or communicate distress.[9] Comorbid conditions such as depression, anxiety, or childhood trauma further elevate the risk, with internalizing behaviors (e.g., anxiety/depression) often mediating links to suicidal behaviors and externalizing behaviors to non-suicidal self-injury.[61] Developmentally, adverse childhood experiences (ACEs), including physical, emotional, or sexual abuse, confer elevated risk for later self-harm via disrupted attachment and heightened vulnerability to psychopathology. Longitudinal studies demonstrate that ACEs predict NSSI through serial effects on anxiety, depression, and emotion dysregulation, with effect sizes persisting into adulthood.[62] [63] NSSI typically emerges in early adolescence (ages 12-14), peaking between 14-16 years, coinciding with pubertal hormonal shifts and increased autonomy-seeking that amplify emotion regulation demands.[64] Family dysfunction and low parental monitoring during this period exacerbate trajectories, as evidenced by meta-analyses linking early trauma to chronic NSSI patterns over 5-10 years.[65] [66] While protective factors like secure attachments can buffer these risks, their absence in high-ACE environments fosters a developmental cascade toward self-injurious coping.[67]Social and Environmental Influences
Childhood maltreatment, including physical, sexual, emotional abuse, and neglect, is a significant environmental risk factor for non-suicidal self-injury (NSSI), with meta-analyses showing odds ratios ranging from 2.0 to 2.8 across these subtypes.30469-8/abstract) [58] Dysfunctional family dynamics, such as parental quarrels, marital disruption, and insecure parent-child attachment, further elevate risk, independent of abuse, by fostering emotional dysregulation and interpersonal sensitivity.[68] Peer victimization through bullying strongly predicts NSSI in adolescents, with meta-analytic evidence indicating that bully victims face 2-3 times higher odds compared to non-involved peers, particularly via verbal and relational forms that exacerbate feelings of isolation.[69] [70] Exposure to peers' self-harm behaviors also contributes via social contagion, where adolescents observing NSSI in friends report increased urges and initiation rates, mediated by normalization and modeling rather than explicit encouragement.00170-6/abstract) [71] Social media amplifies these peer effects, as viewing self-harm imagery or content correlates with heightened NSSI urges and behaviors in vulnerable youth, with experimental studies demonstrating short-term increases in self-harm ideation post-exposure.[72] [73] This contagion appears driven by algorithmic amplification of graphic content, though longitudinal data remain limited and confounded by selection bias in online communities.[74] Socioeconomic deprivation at both individual and area levels is associated with elevated NSSI prevalence, with low childhood income linked to a 20-30% increased risk in adulthood, potentially through chronic stress and reduced access to protective resources like mental health support.[75] [76] Hospital presentations for self-harm show over-representation in deprived areas, with males and ethnic minorities disproportionately affected, underscoring environmental stressors beyond purely psychological factors.[47] Overall, while these influences are empirically supported, effect sizes are modest (ORs typically 1.5-3.0), suggesting interplay with individual vulnerabilities rather than deterministic causation.[77]Biological and Genetic Elements
Twin and family studies have estimated the heritability of non-suicidal self-injury (NSSI) and related self-harm behaviors at approximately 30-60%, indicating a moderate genetic contribution alongside environmental influences. [78] Overlapping genetic factors largely account for the correlation between NSSI and suicidal ideation, suggesting shared etiological pathways rather than distinct mechanisms.[79] [80] Genome-wide association studies (GWAS) have identified specific genetic variants linked to self-harm ideation and behavior, including associations with genes such as LINGO2, FBXO27, and WRB, which may influence neural development and signaling.[78] Additional research from large-scale genetic epidemiology efforts has implicated up to 11 genes in self-harm thoughts and behaviors, with polygenic risk scores showing overlap with broader psychopathology liabilities.[81] Rare variants in genes like SNAPC1 and TNKS1BP1 have also been associated with suicidal behaviors, potentially extending to NSSI through shared genetic architecture.[82] Neurobiologically, self-harm is linked to dysregulation in key neurotransmitter systems, including reduced serotonin and dopamine activity, which contribute to impulsivity and emotional dysregulation, alongside elevated glutamate levels that may heighten excitatory responses.[83] Alterations in brain structure and function, such as reduced gray matter volume in regions like the anterior cingulate cortex and insula, have been observed via magnetic resonance imaging in individuals engaging in NSSI, correlating with impaired emotion regulation and pain processing.[84] [85] Dysfunctions in the hypothalamic-pituitary-adrenal (HPA) axis and inflammatory pathways further underscore biological vulnerabilities, potentially amplifying stress responses that precipitate self-injurious acts.[86] Endocannabinoid and opioid system abnormalities may reinforce NSSI through tolerance and reward mechanisms, akin to addictive processes.[87] These findings highlight polygenic and neurochemical underpinnings, though causal directions remain under investigation due to gene-environment interactions.Role of Substance Use and Comorbidities
Substance use disorders (SUDs) are strongly associated with increased risk of self-harm, with meta-analyses indicating a small but significant positive correlation between non-suicidal self-injury (NSSI) and alcohol use, particularly binge drinking.[88] Acute intoxication from alcohol or other substances impairs impulse control and decision-making, elevating the likelihood of self-harmful acts in vulnerable individuals, as evidenced by studies showing problematic alcohol use doubles the odds of self-harm or suicide attempts compared to non-users.[89] In patients with SUDs, self-harm prevalence reaches 32.7%, linked to factors such as injecting drug use history and polysubstance involvement, which exacerbate impulsivity and emotional dysregulation.[90] Chronic substance use further compounds risk by inducing neurochemical changes that mirror those in mood disorders, creating a bidirectional pathway where self-harm may serve as a maladaptive coping mechanism for withdrawal or cravings, independent of baseline depression or anxiety.[91] Comorbid psychiatric conditions amplify self-harm vulnerability, with NSSI co-occurring in 37-50% of clinical adolescent and young adult samples, often alongside borderline personality disorder (BPD), major depressive disorder, or post-traumatic stress disorder (PTSD).[23] Systematic reviews report lifetime NSSI prevalence in adults with eating disorders or anxiety at 4-23%, where shared etiological factors like emotional dysregulation drive both behaviors.[13] SUDs themselves act as key comorbidities, conferring a fourfold increased odds of NSSI in affected populations, as substance-induced alterations in serotonin and dopamine systems overlap with those implicated in self-harm propensity.[92] This comorbidity cluster—SUDs intersecting with affective and impulse-control disorders—heightens overall risk through synergistic effects, such as intensified negative affect during substance withdrawal, though longitudinal data suggest self-harm can precede and predict subsequent SUD onset in 20-30% of cases, underscoring multifactorial causality rather than unidirectional influence.[91][93]Pathophysiological Mechanisms
Neurological and Neurochemical Processes
Neuroimaging studies reveal structural and functional alterations in brain regions associated with emotion regulation and impulsivity among individuals engaging in non-suicidal self-injury (NSSI). Functional magnetic resonance imaging (fMRI) has shown hyperactivation in the amygdala during emotional reactivity tasks, indicating heightened threat sensitivity and difficulty modulating affective responses.[94] Concurrently, hypoactivation in the prefrontal cortex, particularly the ventromedial and dorsolateral areas, correlates with impaired top-down control over impulsive behaviors and poor decision-making in response to distress.[95] These patterns suggest a neurobiological basis for NSSI as a maladaptive strategy to regulate overwhelming emotions, with deficits in integrating sensory and cognitive inputs.[96] Reward processing networks also exhibit dysregulation, evidenced by altered connectivity in the striatum and orbitofrontal cortex, which may reinforce NSSI through anticipation of relief despite negative long-term consequences.[97] Whole-brain analyses indicate reduced gray matter volume in regions like the anterior cingulate cortex, linked to pain perception and conflict monitoring, potentially lowering the threshold for self-inflicted harm.[98] Such findings from coordinate-based meta-analyses underscore NSSI's association with disrupted salience detection and habituation to aversive stimuli.[97] Neurochemically, NSSI triggers the release of endogenous opioids, including beta-endorphins, which bind to mu-opioid receptors and induce analgesia and euphoria, possibly contributing to the behavior's reinforcement.[99] Salivary beta-endorphin levels positively correlate with injury severity, supporting an opioid-mediated pain offset mechanism that temporarily alleviates emotional distress.[100] The hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, as posited in the opioid homeostasis model, further implicates dysregulated stress responses, where chronic cortisol elevation exacerbates vulnerability to NSSI for homeostasis restoration.[101] Evidence for serotonergic or dopaminergic involvement remains inconsistent, with cerebrospinal fluid studies showing no significant metabolite differences compared to controls, challenging simplistic monoamine hypotheses.[102]Physiological and Autonomic Responses
Individuals engaging in non-suicidal self-injury (NSSI) frequently demonstrate elevated pain thresholds and reduced sensitivity to experimentally induced nociceptive stimuli compared to controls, a phenomenon termed hypoalgesia.[103] This altered pain processing persists even during anticipation of pain, with NSSI participants showing delayed parasympathetic withdrawal as measured by heart rate variability (RMSSD; p=0.008).[103] The endogenous opioid system plays a central role in these responses, with NSSI associated with lower baseline cerebrospinal fluid concentrations of β-endorphin (91.4 ± 14.1 ng/ml vs. 105.9 ± 19.2 ng/ml in controls) and met-enkephalin (45.7 ± 8.1 ng/ml vs. 58.4 ± 12.1 ng/ml).[102] These deficiencies may drive self-injury as a means to restore opioid homeostasis, modulating pain perception and providing transient emotional relief through stress-induced analgesia.[102] Immediately following NSSI acts, salivary β-endorphin levels rise significantly (Cohen’s d=0.82, p=0.001), with elevations positively correlated to injury severity (β=0.2, p=0.009) across 148 documented instances, though not to subjective pain ratings.[100] This post-injury opioid surge likely contributes to the reinforcing properties of NSSI by attenuating distress and promoting a sense of calm.[100] Autonomic responses in NSSI are characterized by baseline hypoactivity in the parasympathetic branch (Hedges’ g=-0.30 pre-stress, g=-0.54 post-recovery), alongside intact acute sympathetic-parasympathetic reactivity to laboratory stressors.[104] Post-pain recovery is prolonged, evidenced by slower vagal reactivation (p=0.045) and heightened hypothalamic-pituitary-adrenal axis output via elevated cortisol in some contexts (p=0.044), indicating broader dysregulation in arousal modulation.[103][104] Meta-analytic synthesis across 29 studies confirms flattened cortisol reactivity (g=-0.26), underscoring impaired stress adaptation rather than hyper-reactivity.[104]Clinical Presentation and Consequences
Behavioral Signs and Symptoms
Nonsuicidal self-injury (NSSI) encompasses deliberate behaviors aimed at damaging one's own body tissue without suicidal intent, often as a private method of emotional regulation.[4] These acts are typically repetitive, controlled, and patterned, targeting accessible body areas such as the forearms, wrists, thighs, abdomen, or legs.[26][105] Common methods include:- Cutting, scratching, or stabbing the skin with sharp objects like razors or knives.[26][105]
- Burning the skin using lit cigarettes, matches, heated implements, or chemicals.[26][105]
- Self-hitting, punching solid objects to bruise oneself, head-banging, or biting.[26][105]
- Carving symbols or words into the skin, piercing with sharp items, or inserting objects under the skin.[26]
- Excessive rubbing or scratching to induce friction burns or skin breakdown.[26][105]
- Persistently wearing long sleeves, pants, or other covering clothing, even in warm weather, to hide injuries.[26][105]
- Frequent claims of "accidental" injuries resulting in scratches, bruises, bite marks, or swelling.[26][105]
- Maintaining possession of sharp objects, lighters, or other potential tools for self-injury.[26]
- Avoidance of medical attention for injuries or nervousness when wounds are examined.[26]
Short- and Long-Term Outcomes
Short-term outcomes of self-harm primarily involve acute physical injuries and transient psychological effects. Common methods such as cutting or burning result in lacerations, abrasions, or thermal injuries that carry risks of hemorrhage, infection, and delayed wound healing, particularly in individuals with poor hygiene or immunosuppression from comorbidities.[108] The healing process for self-inflicted cuts on the forearm, a common site, follows the standard four stages of wound healing for skin lacerations: hemostasis (immediate), where blood clots form to stop bleeding; inflammation (1-5 days), involving immune response with redness, swelling, and wound cleaning; proliferation (4-21 days), during which granulation tissue forms, skin cells migrate to close the wound, and new blood vessels develop; and remodeling/maturation (weeks to over 2 years), where scar tissue strengthens to about 80% of original strength by 3 months and fades over time.[109][110] Superficial cuts, prevalent in self-harm, typically close and scab within 1-3 weeks, with visible healing in 1-2 weeks; the forearm location generally promotes healing due to good blood supply, though repetitive movement may slightly delay it. Proper care, including cleaning with water, bandaging, and infection prevention, accelerates recovery. However, deep cuts, particularly on the wrist or hand, carry a higher risk of severe blood loss due to proximity to major blood vessels. Key signs requiring immediate emergency care (calling emergency services) for heavy blood loss from a self-inflicted cut include:- Bleeding that spurts out (bright red, pulsatile - possible arterial bleeding).
- Bleeding that does not stop after applying firm, direct pressure for 10-15 minutes.
- Blood soaking through dressings/bandages repeatedly.
- Signs of shock: weakness, clammy/cold skin, rapid/weak pulse, dizziness, confusion, pale appearance.
- Deep/large wound (>5cm), especially on palm/wrist, or if tendons/nerves/vessels may be damaged.