The Wayana (alternate names: Ajana, Uaiana, Alucuyana, Guaque, Ojana, Oyana, Orcocoyana, Pirixi, Urukuena, Waiano etc.) are a Carib-speaking people located in the southeastern part of the Guiana highlands, a region divided between Brazil, Suriname, and French Guiana. In 1980, when the last census took place, the Wayana numbered some 1,500 individuals, of which 150 in Brazil, among the Apalai, 400 in Suriname, and 1,000 in French Guiana, along the Maroni River. About half of them still speak their original language.

According to both oral tradition and descriptions by 20th century European explorers, the Wayana emerged fairly recently as a distinctive group; contemporary Wayana are considered an amalgation of smaller ethnic groups such as the Upului, Opagwana, and Kukuyana. In the eighteenth century, the ancestors of the Wayana lived along the Paru and Jari rivers in contemporary Brazil, and along the upper tributaries of the Oyapock river, which nowadays forms the border between French Guiana and Brazil.

The first recorded mentioning of the tribe was in 1769 across a Wayana village. By the late 18th century, the ancestors of the Wayana were involved in an almost continuous military struggle with Tupi peoples such as the Wayampi, which drove them across the Tumuk Humak Mountains to the upper tributaries of the Litani river. Around the same time, the Aluku maroons, who had fled plantations in Suriname, were driven up the Litani river by Dutch colonial forces aided by Ndyuka maroons, who had settled for peace with the colonial authorities in return for military assistance against "incursions" from new maroon groups. From that moment on, an intensive trade relationship developed between the Wayana and the Aluku, and both tribes often living together in the same villages. In 1815, the Aluku and Wayana became blood brothers.

Over time, the Wayana migrated with the Aluku further downstream the Litani and Lawa rivers to end up in their contemporary position. In 1865, the Ndyuka granman Alabi invited a Wayana group still living along the Paru river in Brazil to join them along the Tapanahony river in Suriname, probably inspired by the arrangement with the Wayana that the Aluku had. This particular group still lives in villages along the Tapanahony and Palumeu rivers.

Despite limited contacts with outsiders, imported diseases ravished the tribe in the early 20th century, and reduced the population to an estimated 500 to 600 people. From 1962 onward, American missionaries from the West-Indies Mission, who had previously worked with the Tiriyó, encouraged the population to concentrate in larger villages and provided access to health care, schooling, and to make it easier to convert the population. The French part of the interior used to be the Territory of Inini which allowed for an autonomous and self sufficient tribal system for the native population without clear borders. In 1968 the Wayana settlements in France became part of the Grand-Santi-Papaïchton community circle of French Guiana which became separate communes a year later. Along with the commune, came a government structure, and francisation. In the late 1980s, the Surinamese Interior War stopped development on the Suriname side and many fled to the French side of the border. The late 20th and early 21st century marked the beginning of (eco)tourism, but also illegal gold mining. Along with miners came the bars, prostitution, and gambling. The Maripasoula commune is sometimes referred to as "Far West" in the mainstream French media, because of its high crime rate.

Wayana society is characterized by a rather low degree of social stratification. Villages often comprise not more than one extended family and are rather loosely linked to their neighbouring villages by kinship ties, marital exchanges, shared rituals and trade. Missionaries and representatives of the state have only partially succeeded in grouping the Wayana together in larger settlements, and despite the fact that the Wayana are not as nomadic as before, villages are by no means permanent, and are often abandoned after the death of a leader.

Villages are often led by a shaman or pïyai, who mediate Wayana contact with the world of spirits and deities, act as healers, and who are consulted in matters concerning hunting and fishing. Many Wayana villages still feature a community house or tukusipan.

Coming of age was for a long time associated with a ritual called ëputop or maraké, in which a wicker frame full of stinging ants or wasps was applied to the bodies of adolescent boys and girls, who emerged from the ceremony as adult men and women. While older Wayana still to a degree define their Wayanahood by the number of ëputop they underwent during their lifetime, many younger Wayana reject the necessity of undergoing ëputop to become a valued member of society. As a result, few ëputop ceremonies occur today. One of the more recent ëputop ceremonies took place in 2004 in the village of Talhuwen, organized by Aïmawale Opoya, grandson of Wayana leader Janomalë, in consultation with French film director Jean-Philippe Isel, who made a documentary about the ritual.